Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients

Journal of Autoimmunity

Volumn 19, Issue 1-2, 2002, Pages 63-70

  Rapoport, Micha J ^a   Amit, Mirit ^a   Aharoni, Dorit ^a   Weiss, Mordechai ^a   Weissgarten, Joshua ^a   Bruck, Nathan ^a   Buchs, Andreas ^a   Bistritzer, Tzvi ^a   Molad, Yair ^b  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Human; Lupus; MAP kinase; P21Ras; Signal transduction; T lymphocytes

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SOS PROTEIN;

ADULT; AGED; ARTICLE; CELL MEMBRANE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; LYMPHOCYTE; METABOLISM; MIDDLE AGED; UPREGULATION;

ADULT; AGED; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTES; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEIN P21(RAS); P120 GTPASE ACTIVATING PROTEIN; SOS1 PROTEIN; UP-REGULATION;

EID: 0036700624     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2002.0596     Document Type: Article

References (31)

1. Boumpas D.T., Mark G.E., Tsokos G.C. 1986. Oncogenes and autoimmunity. Anti Cancer Res. 6: 491-497
2. Liossis S.N.C., Ding X.Z., Dennis G.J., Tsokos G.C. 1998. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T Cells from patients with systemic lupus erythemathosus. Deficient expression of the T-cell receptor zeta chain. J. Clin. Invest. 101: 1448-1457
3. Tsokos G.C., Wong H.K., Enyedy E.J., Nambiar M.P. 2000. Immune cell signaling in lupus. Curr. Opin. Rheumatol. 12: 355-363
4. Brundula V., Rivas L.J., Blasini A.M., Paris M., Salazar S., Stekman I.L., Rodriguez M.A. 1999. Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 42: 1908-1916
5. Yi Y., McNerney M., Datta S.K. 2000. Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. J. Immunol. 165: 6627-6634
6. Deng C., Kaplan M.J., Yang J., Ray D., Zhang Z., McCune W.J., Hanash S.M., Richardson B.C. 2001. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum. 44: 397-407
7. Bourne H.R., Sanders D.A., McCormick F. 1990. The GTPase superfamily: a conserved switch to diverse cell functions. Nature 348: 125-131
8. Izquierdo P.M., Reif K., Cantrell D. 1995. The regulation and function of p21ras during T-cell activation and growth. Immunol. Today 16: 159-164
9. Boguski M.S., McCormick F. 1993. Proteins regulating Ras and its relatives. Nature 366: 643-654
10. Pawson T. 1995. Protein modules and signaling networks. Nature 373: 573-580
11. Li N., Batzer A., Dali R., Yajnik V., Skolnik E., Chardin P., Bar-Sagi D., Margolis B., Schlessinger J. 1993. Guanine-nucleotide-releasing factor hSOS1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363: 85-88
12. Buday L., Downward J. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and SOS nucleotide exchange factor. Cell 73: 611-620
13. Salojin K., Zhang J., Cameron M., Gill B., Arreaza G., Ochi A., Delovitch T.L. 1997. Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-σ-cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice. J. Exp. Med. 186: 887-897
14. Rubinfeld H., Hanoch T., Seger R. 1999. Identification of a cytoplasmic retention sequence in ERK2. J. Biol. Chem. 274: 30349-30352
15. Cohen P.L., Eisenberg R.A. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphorproliferative disease. Annu. Rev. Immunol. 9: 243-269
16. Steinberg A.D., Klinman D.M., Kastner D.L., Seldin M.F., Gause W.C., Scriber C.L., Britten J.L., Siegel J.N., Mountz J.D. 1987. Genetic and molecular genetic studies of murine and human lupus. J. Rheumatol. (suppl B) 14: 166-176
17. Rapoport M.J., Mor A., Amit M., Rosenberg R., Ramot Y., Mizrachi A., Wysenbeek A.J. 1999. Decreased expression of the p21ras stimulatory factor hSOS in PBMC from inactive SLE patients. Lupus 8: 24-28
18. Bombardier C., Gladman D.D., Urowitz M.B., Caron D., Chang C.H. and the committee on prognosis studies in systemic lupus erythemathosus. 1992. Derivation of the SLEDAI; a disease activity index for lupus patients. Arthritis Rheum. 35: 630-640
19. Petri M., Hellman D., Hochberg M. 1992. Validity and reliability of Lupus activity measures in the routine clininc setting. J. Rheumatol. 19: 53-59
20. Buck C.A., Horwitz A.F. 1987. Integrin, a transmembrane glycoprotein complex mediating cell substratum adhesion. J. Cell Sci. Suppl. 8: 231-250
21. Karunagaran D., Tzahar E., Beerli R.R., Chen X., Graus-Porta D., Ratzkin B.J., Seger R., Hynes N.E., Yarden Y. 1996. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15: 254-264
22. Stokoe D., Macdonald S.G., Cadwallader K., Symons M., Hancock J.F. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264: 1463-1467
23. Leevers S.J., Paterson H.F., Marshall C.J. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369: 411-414
24. Gana-Weisz M., Haklai R., Marciano D., Egozi Y., Ben-Baruch G., Kloog Y. 1997. The Ras antagonist S-Farnesylthiosalicylic acid induces inhibition of MAPK activation. Biochem. Biophys. Res. Commun. 239: 900-904
25. Egan S.E., Giddings B.W., Brooks M.W., Buday L., Sizeland A.M., Weinberg R.A. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in signal transduction and transformation. Nature (Lond.) 363: 45-51
26. Huang D.C.S., Marshall C.J., Hancock J.F. 1993. Plasma membrane-targeted GTPase-activating protein is a potent suppressor of p21ras function. Mol. Cell. Biol. 13: 2420-2431
27. Cherniack A.D., Klarlund J.K., Conway B.R., Czech M.P. 1995. Disassembly of Son-of sevenless proteins from Grb2 during p21ras desensitization by insulin. J. Biol. Chem. 270: 1485-1488
28. Corbalan-Garcia S., Yang S-S., Degenhardt K.R., Bar-Sagi D. 1996. Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Mol. Cell. Biol. 10: 5674-5682
29. Rapoport M.J., Mor A., Vardi P., Ramot Y., Levi O., Bistritzer T. 1999. Defective activation of p21ras in peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus. Autoimmunity 29: 147-154
30. Rapoport M.J., Weiss L., Mor A., Bistritzer T., Ramot Y., Slavin S. 1996. Prevention of autoimmune diabetes by linomide in nonobese diabetic (NOD) mice is associated with up-regulation of the TCR-mediated activation of p21(ras). J. Immunol. 157: 4721-4725
31. Confino-Cohen R., Aharoni D., Goldberg A., Gurevitch I., Buchs A., Weiss M., Weissgarten J., Rapoport M.J. 2002. Evidence for aberrant regulation of the p21Ras pathway in PBMCs of patients with chronic idiopathic urticaria. J. Allergy Clin. Immunol. 109: 349-356