Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase

Clinical Immunology

Volumn 117, Issue 3, 2005, Pages 262-270

  Rapoport, Micha J ^a,b   Sharabi, Amir ^c   Aharoni, Dorit ^a,b   Bloch, Olga ^a,b   Zinger, Heidy ^c   Dayan, Molly ^c   Mozes, Edna ^c  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

(NZBxNZW)F1 mice; Apoptosis; CDR based peptides; Immunomodulation; JNK kinase; Lupus; p21Ras pathway

Indexed keywords

AUTOANTIBODY; EDRATIDE; GLYCYLTYROSYLTYROSYLTRYPTOPHYLSERYLTRYPTOPHYLISOLEUCYLARGINYLGLUTAMINYL PROLYLPROLYLGLYCYLLYSYLGLYCYLGLUTAMYLGLUTAMYLTRYPTOPHYLISOLEUCYLGLYCINE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PROTEIN P21; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CLINICAL FEATURE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVE SITE; FEMALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; COMPLEMENTARITY DETERMINING REGIONS; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; IMMUNIZATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MAP KINASE KINASE 4; MICE; MICE, INBRED NZB; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 29344448889     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2005.09.003     Document Type: Article

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