Differential anti-inflammatory and chondroprotective effects of simulated digests of indomethacin and an herbal composite (Mobility™) in a cartilage explant model of articular inflammation

Journal of Veterinary Pharmacology and Therapeutics

Volumn 30, Issue 6, 2007, Pages 523-533

  Pearson, W ^a   Orth, M W ^b   Lindinger, M I ^c  

^a Cantox Health Sciences International   (Canada)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

'MOBILITY'; ARCTIUM LAPPA EXTRACT; COMFREY EXTRACT; GLYCOSAMINOGLYCAN; HARPAGOPHYTUM EXTRACT; HARPAGOPHYTUM PROCUMBENS EXTRACT; INDOMETACIN; PLANT EXTRACT; PROSTAGLANDIN E2; TARAXACUM OFFICINALE EXTRACT; UNCLASSIFIED DRUG; URTICA DIOICA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARCTIUM; ARTHROPATHY; ARTICLE; COMFREY; CONTROLLED STUDY; DANDELION; DRUG EFFECT; HARPAGOPHYTUM; HEART PROTECTION; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; URTICA DIOICA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARTILAGE, ARTICULAR; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HORSE DISEASES; HORSES; INDOMETHACIN; INTERLEUKIN-1; MODELS, BIOLOGICAL; NITRIC OXIDE; OSTEOARTHRITIS; PHYTOTHERAPY; PLANT BARK; PLANT PREPARATIONS; PROTECTIVE AGENTS; SALIX; SWINE;

EQUIDAE;

EID: 35848963846     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2007.00905.x     Document Type: Article

References (92)

1. Akiba, Y., Guth, P.H., Engel, E., Nastaskin, I. Kaunitz, J.D. (2000) Dynamic regulation of mucus gel thickness in rat duodenum. American Journal of Physiology Gastrointestinal Liver Physiology, 279, G437 G447.
2. Alexopoulos, L.G., Williams, G.M., Upton, M.L., Setton, L.A. Guilak, F. (2005) Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Journal of Biomechanics, 38, 509 517.
3. Andersen, M.L., Santos, E.H., Seabra, L., da Silva, A.A. Tufik, S. (2004) Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats. Journal of Ethnopharmacology, 91, 325 330.
4. Arner, E.C., Hughes, C.E., Decicco, C.P., Caterson, B. Tortorella, M.D. (1998) Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. Osteoarthritis and Cartilage, 6, 214 228.
5. Arsenis, C. McDonnell, J. (1989) Effects of antirheumatic drugs on the interleukin-1 alpha induced synthesis and activation of proteinases in articular cartilage explants in culture. Agents and Actions, 27, 261 264.
6. Beluche, L.A., Bertone, A.L., Anderson, D.E. Rohde, C. (2001) Effects of oral administration of phenylbutazone to horses on in vitro articular cartilage metabolism. American Journal of Veterinary Research, 62, 1916 1921.
7. Betz, J.M., Eppley, R.M., Taylor, W.C. Andrzejewski, D. (1994) Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp.). Journal of Pharmaceutical Science, 83, 649 653.
8. Bica, B.E., Gomes, N.M., Fernandes, P.D., Luiz, R.R. Koatz, V.L. (2007) Nitric oxide levels and the severity of juvenile idiopathic arthritis. Rheumatology International, 27, 819 825.
9. Bruneton, J. (1999) Pharmacognosy, Phytochemistry, Medicinal Plants, 2nd edn. Lavoisier Publishing Inc, Paris.
10. Cao, M., Westerhausen-Larson, A., Niyibizi, C., Kavalkovich, K., Georgescu, H.I., Rizzo, C.F., Hebda, P.A., Stefanovic-Racic, M. Evans, C.H. (1997) Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochemistry Journal, 324, 305 310.
11. Catelan, S.C., Belentani, R.M., Marques, L.C., Silva, E.R., Silva, M.A., Caparroz-Assef, S.M., Cuman, R.K. Bersani-Amado, C.A. (2006) The role of adrenal corticosteroids in the anti-inflammatory effect of the whole extract of Harpagophytum procumbens in rats. Phytomedicine, 13, 446 451.
12. Chandrasekhar, S., Esterman, M.A. Hoffman, H.A. (1987) Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Analytical Biochemistry, 161, 103 108.
13. Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Maity, P. Banerjee, R.K. (2006) Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radical Biology and Medicine, 40, 1397 1408.
14. Choi, Y.H., Yan, G.H., Chai, O.H., Lim, J.M., Sung, S.Y., Zhang, X., Kim, J.H., Choi, S.H., Lee, M.S., Han, E.H., Kim, H.T. Song, C.H. (2006) Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biological & Pharmaceutical Bulletin, 29, 1360 1365.
15. Chrubasik, S., Kunzel, O., Model, A., Conradt, C. Black, A. (2001) Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology, 40, 1388 1393.
16. Chrubasik, S., Conradt, C. Roufogalis, B.D. (2004) Effectiveness of Harpagophytum extracts and clinical efficacy. Phytotherapy Research, 18, 187 189.
17. Coleman, P.J., Scott, D., Ray, J., Mason, R.M. Levick, J.R. (1997) Hyaluronan secretion into the synovial cavity of rabbit knees and comparison with albumin turnover. Journal of Physiology, 503, 645 656.
18. Court, M.H. (2001) Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6. Journal of Veterinary Pharmacology and Therapeutics, 24, 415 422.
19. Couzin, J. (2004) Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors. Science, 306, 384 385.
20. Curran, J.M., Sutherland, R.J. Peet, R.L. (1996) A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis. Australian Veterinary Journal, 74, 236 240.
21. Cuzzocrea, S. (2006) Role of nitric oxide and reactive oxygen species in arthritis. Current Pharmaceutical Design, 12, 3551 3570.
22. Dechant, J.E., Baxter, G.M., Frisbie, D.D., Trotter, G.W. McIlwraith, C.W. (2005) Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism. Equine Veterinary Journal, 37, 227 231.
23. Dieppe, P.A., Ebrahim, S., Martin, R.M. Jüni, P. (2004) Lessons from the withdrawal of rofecoxib. BMJ, 329, 867 868.
24. Eichler, O. Koch, C. (1970) Antiphlogistic, analgesic and spasmolytic effect of harpagoside, a glycoside from the root of Harpagophytum procumbens DC. Arzneimittelforschung, 20, 107 109.
25. Fenton, J.I., Chlebek-Brown, K.A., Caron, J.P. Orth, M.W. (2002) Effect of glucosamine on interleukin-1-conditioned articular cartilage. Equine Veterinary Journal Supplement, 34, 219 223.
26. Forro, M., Cieslar, S., Ecker, G.L., Hahn, J. Lindinger, M.I. (2000) Total body water and ECFV measured using bioelectrical impedance analysis and indicator dilution in horses. Journal of Applied Physiology, 89, 663 671.
27. Frean, S.P., Cambridge, H. Lees, P. (2002) Effects of anti-arthritic drugs on proteoglycan synthesis by equine cartilage. Journal of Veterinary Pharmacology and Therapeutics, 25, 289 298.
28. Gagnier, J.J., Chrubasik, S. Manheimer, E. (2004) Harpagophytum procumbens for osteoarthritis and low back pain: a systematic review. BMC Complementary and Alternative Medicine, 4, 13.
29. Ganguly, K., Kundu, P., Banerjee, A., Reiter, R.J. Swarnakar, S. (2006) Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radical Biology and Medicine, 41, 911 925.
30. Goodrich, L.R. Nixon, A.J. (2006) Medical treatment of osteoarthritis in the horse- a review. Veterinary Journal, 171, 51 69.
31. Grube, B., Grunwald, J., Krug, L. Staiger, C. (2007) Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial. Phytomedicine, 14, 2 10.
32. Gruber, J., Vincent, T.L., Hermansson, M., Bolton, M., Wait, R. Saklatvala, J. (2004) Induction of interleukin-1 in articular cartilage by explantation and cutting. Arthritis and Rheumatism, 50, 2539 2546.
33. Harput, U.S., Saracoglu, I. Ogihara, Y. (2005) Stimulation of lymphocyte proliferation and inhibition of nitric oxide production by aqueous Urtica dioica extract. Phytotherapy Research, 19, 346 348.
34. Hu, C. Kitts, D.D. (2005) Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro. Phytomedicine, 12, 588 597.
35. Huang, T.H., Tran, V.H., Duke, R.K., Tan, S., Chrubasik, S., Roufogalis, B.D. Duke, C.C. (2006) Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. Journal of Ethnopharmacology, 104, 149 155.
36. Hudaib, M., Speroni, E., Di Pietra, A.M. Cavrini, V. (2002) GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle. Journal of Pharmaceutical and Biomedical Analysis, 29, 691 700.
37. Inoue, K., Masuko-Hongo, K., Okamoto, M. Nishioka, K. (2005) Induction of vascular endothelial growth factor and matrix metalloproteinase-3 (stromelysin) by interleukin-1 in human articular chondrocytes and synoviocytes. Rheumatology International, 26, 93 98.
38. Kararli, T.T. (1995) Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharmaceutics and Drug Disposition, 16, 351 380.
39. Kaszkin, M., Beck, K.F., Koch, E., Erdelmeier, C., Kusch, S., Pfeilschifter, J. Loew, D. (2004) Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine, 11, 585 595.
40. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H.G., Petrowicz, O., Giannetti, B., Klingenburg, S. Staiger, C. (2004) Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine, 11, 470 477.
41. Lanhers, M.C., Fleurentin, J., Mortier, F., Vinche, A. Younos, C. (1992) Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Medica, 58, 117 123.
42. Levy, D. Zochodne, D.W. (2004) NO pain: potential roles of nitric oxide in neuropathic pain. Pain Practice, 4, 11 18.
43. Liacini, A., Sylvester, J. Zafarullah, M. (2005) Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochemistry and Biophysics Research Communications, 327, 320 327.
44. Lorenz, J.J., Furdon, P.J., Taylor, J.D., Verghese, M.W., Chandra, G., Kost, T.A., Haneline, S.A., Roner, L.A. Gray, J.G. (1995) A cyclic adenosine 3′,5′-monophosphate signal is required for the induction of IL-1 beta by TNF-alpha in human monocytes. Journal of Immunology, 155, 836 844.
45. Mamdani, M., Juurlink, D.N., Lee, D.S., Rochon, P.A., Kopp, A., Naglie, G., Austin, P.C., Laupacis, A. Stukel, T.A. (2004) Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. Lancet, 363, 1751 1756.
46. Marciani, L., Bush, D., Wright, P., Wickham, M., Pick, B., Wright, J., Faulks, R., Fillery-Travis, A., Spiller, R.C. Gowland, P.A. (2005) Monitoring of gallbladder and gastric coordination by EPI. Journal of Magnetic Resonance Imaging, 21, 82 85.
47. Martin, J. Dusek, J. (2002) The Baikal scullcap (Scutellaria baicalensis Georgi) - a potential source of new drugs. Ceská a Slovenská Farmacie, 51, 277 283.
48. Matsumura, S., Abe, T., Mabuchi, T., Katano, T., Takagi, K., Okuda-Ashitaka, E., Tatsumi, S., Nakai, Y., Hidaka, H., Suzuki, M., Sasaki, Y., Minami, T. Ito, S. (2005) Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype. Biochemistry and Biophysics Research Communications, 338, 550 557.
49. McGuire-Goldring, M.B., Meats, J.E., Wood, D.D., Ihrie, E.J., Ebsworth, N.M. Russell, R.G. (1984) In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. Arthritis and Rheumatism, 27, 654 662.
50. Mei, N., Guo, L., Fu, P.P., Heflich, R.H. Chen, T. (2005) Mutagenicity of comfrey (Symphytum officinale) in rat liver. British Journal of Cancer, 92, 873 875.
51. Mei, N., Guo, L., Zhang, L., Shi, L., Sun, Y.A., Fung, C., Moland, C.L., Dial, S.L., Fuscoe, J.C. Chen, T. (2006) Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale). BMC Bioinformatics, 7, S16.
52. Meschter, C.L., Gilbert, M., Krook, L., Maylin, G. Corradino, R. (1990) The effects of phenylbutazone on the morphology and prostaglandin concentrations of the pyloric mucosa of the equine stomach. Veterinary Pathology, 27, 244 253.
53. Minami, T., Nakano, H., Kobayashi, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S. Ito, S. (2001) Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. British Journal of Pharmacology, 133, 438 444.
54. Miwa, M., Saura, R., Hirata, S., Hayashi, Y., Mizuno, K. Itoh, H. (2000) Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway. Osteoarthritis and Cartilage, 8, 17 24.
55. Morton, A.J., Campbell, N.B., Gayle, J.M., Redding, W.R. Blikslager, A.T. (2005) Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis. Research in Veterinary Science, 78, 189 192.
56. Nakayama, Y., Omote, K., Kawamata, T. Namiki, A. (2004) Role of prostaglandin receptor subtype EP1 in prostaglandin E2-induced nociceptive transmission in the rat spinal dorsal horn. Brain Research, 1010, 62 68.
57. Nizamutdinova, I.T., Oh, H.M., Min, Y.N., Park, S.H., Lee, M.J., Kim, J.S., Yean, M.H., Kang, S.S., Kim, Y.S., Chang, K.C. Kim, HJ. (2007) Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. International Journal of Immunopharmacology, 7, 343 350.
58. Oke, S., Aghazadeh-Habashi, A., Weese, J.S. Jamali, F. (2006) Evaluation of glucosamine levels in commercial equine oral supplements for joints. Equine Veterinary Journal, 38, 93 95.
59. Olaleye, S.B. Farombi, E.O. (2006) Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. Phytotherapy Research, 20, 14 20.
60. Owens, J.G., Kamerling, S.G., Stanton, S.R., Keowen, M.L. Prescott-Mathews, J.S. (1996) Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses. American Journal of Veterinary Research, 57, 866 874.
61. Panico, A.M., Cardile, V., Avondo, S., Garufi, F., Gentile, B., Puglia, C., Bonina, F., Santagati, N.A. Ronsisvalle, G. (2006) The in vitro effect of a lyophilized extract of wine obtained from Jacquez grapes on human chondrocytes. Phytomedicine, 13, 522 526.
62. Patrignani, P., Capone, M.L. Tacconelli, S. (2003) Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor. Expert Opinions in Pharmacotherapy, 4, 265 284.
63. Pearson, W., Orth, M.W., Karrow, N.A., MacLusky, N. Lindinger, M.I. (2007) Anti-inflammatory and chondroprotective effects of nutraceuticals in a cartilage explant model of inflammation. Molecular Nutrition and Food Research, in press.
64. Poonam, D., Vinay, C.S. Gautam, P. (2005) Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing. European Journal of Pharmacology, 519, 277 284.
65. Quinn, T.M., Morel, V. Meister, J.J. (2001) Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. Journal of Biomechanics, 34, 1463 1469.
66. Rainsford, K.D., Ying, C. Smith, F.C. (1997) Effects of meloxicam, compared with other NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture. Journal of Pharmacy and Pharmacology, 49, 991 998.
67. Rainsford, K.D., Skerry, T.M., Chindemi, P. Delaney, K. (1999) Effects of the NSAIDs meloxicam and indomethacin on cartilage proteoglycan synthesis and joint responses to calcium pyrophosphate crystals in dogs. Veterinary Research Communications, 23, 101 113.
68. 2 on accumulation of collagen and steady-state levels of pro alpha 1(I) collagen messenger RNA in experimental granulation tissue in rats. Archives of Dermatology Research, 289, 219 223.
69. Reddy, S.V., Wanchu, A., Khullar, M., Govindrajan, S. Bambery, P. (2005) Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis. International Immunopharmacology, 5, 1085 1090.
70. Reed, S.K., Messer, N.T., Tessman, R.K. Keegan, KG. (2006) Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses. American Journal of Veterinary Research, 67, 398 402.
71. Rigano, D., Grassia, A., Borrelli, F., Aviello, G., Piozzi, F., Bruno, M., Arnold, N.A., Capasso, R. Senatore, F. (2006) Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum. Planta Medica, 72, 575 578.
72. Rininger, J.A., Kickner, S., Chigurupati, P., McLean, A. Franck, Z. (2000) Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. Journal of Leukocyte Biology, 68, 503 510.
73. Rowlinson, S.W., Crews, B.C., Goodwin, D.C., Schneider, C., Gierse, J.K. Marnett, L.J. (2000) Spatial requirements for 15-(R)-hydroxy-5Z, 8Z, 1Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete. Journal of Biological Chemistry, 275, 6586 6591.
74. Sakaguchi, Y., Shirahase, H., Ichikawa, A., Kanda, M., Nozaki, Y. Uehara, Y. (2004) Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice. Life Sciences, 75, 2257 2267.
75. Sasaki, K., Hattori, T., Fujisawa, T., Takahashi, K., Inoue, H. Takigawa, M. (1998) Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. Journal of Biochemistry (Tokyo), 123, 431 439.
76. Schnyder, J., Payne, T. Dinarello, C.A. (1987) Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. Journal of Immunology, 138, 496 503.
77. Schulze-Tanzil, G., de, SP., Behnke, B., Klingelhoefer, S., Scheid, A. Shakibaei, M. (2002) Effects of the antirheumatic remedy hox alpha - a new stinging nettle leaf extract - on matrix metalloproteinases in human chondrocytes in vitro. Histology and Histopathology, 17, 477 485.
78. Schulze-Tanzil, G., Hansen, C. Shakibaei, M. (2004) Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro. Arzneimittelforschung, 54, 213 220.
79. 2 release by cyclo-oxygenase 1. Experimental Physiology, 91, 1015 1024.
80. Soulimani, R., Younos, C., Mortier, F. Derrieu, C. (1994) The role of stomachal digestion on the pharmacological activity of plant extracts, using as an example extracts of Harpagophytum procumbens. Canadian Journal of Physiology and Pharmacology, 72, 1532 1536.
81. Stulzer, H.K., Tagliari, M.P., Zampirolo, J.A., Cechinel-Filho, V. Schlemper, V. (2006) Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. Journal of Ethnopharmacology, 108, 379 384.
82. Surendran, S., Kim, S.H., Jee, B.K., Ahn, S.H., Gopinathan, P. Han, C.W. (2006) Anti-apoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis. Journal of Bone and Joint Surgery (British), 88, 1660 1665.
83. Taskiran, D., Stefanovic-Racic, M., Georgescu, H. Evans, C. (1994) Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochemistry and Biophysics Research Communications, 200, 142 148.
84. Trumble, T.N. (2005) The use of nutraceuticals for osteoarthritis in horses. Veterinary Clinics of North America. Equine Practice, 21, 575 597.
85. Ueno, A., Matsumoto, H., Naraba, H., Ikeda, Y., Ushikubi, F., Matsuoka, T., Narumiya, S., Sugimoto, Y., Ichikawa, A. Oh-ishi, S. (2001) Major roles of prostanoid receptors IP and EP(3) in endotoxin-induced enhancement of pain perception. Biochemistry and Pharmacology, 62, 157 160.
86. Uitterlinden, E.J., Jahr, H., Koevoet, J.L., Jenniskens, Y.M., Bierma-Zeinstra, S.M., Degroot, J., Verhaar, J.A., Weinans, H. van Osch, G.J. (2006) Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis and Cartilage, 14, 250 257.
87. Van Breemen, R.B., Fong, H.H. Farnsworth, N.R. (2007) The role of quality assurance and standardization in the safety of botanical dietary supplements. Chemical Research in Toxicology, 20, 577 582.
88. Von Euler, U.S. (1935) Über die spezifische blutdrucksenkende Substanz des menschlichen Prostata- und Samenblasensekrets. Klinische Wochenschrift, 14, 1182 1183.
89. Wallace, J.L., Keenan, C.M. Granger, DN. (1990) Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. American Journal of Physiology, 259, G462 G467.
90. Wu, S.J., Tsai, J.Y., Chang, S.P., Lin, D.L., Wang, S.S., Huang, S.N. Ng, L.T. (2006) Supercritical carbon dioxide extract exhibits enhanced antioxidant and anti-inflammatory activities of Physalis peruviana. Journal of Ethnopharmacology, 108, 407 413.
91. Yang, W. (2002) Studies on the stabilities of bioactive selenocompounds in selenium-enriched garlic and onion. Journal of Hygiene Research, 31, 252 255.
92. Zahner, G., Harendza, S., Müller, E., Wolf, G., Thaiss, F. Stahl, R.A. (1997) Prostaglandin E2 stimulates expression of matrix metalloproteinase 2 in cultured rat mesangial cells. Kidney International, 51, 1116 1123.