The role of adrenal corticosteroids in the anti-inflammatory effect of the whole extract of Harpagophytum procumbens in rats

Phytomedicine

Volumn 13, Issue 6, 2006, Pages 446-451

  Catelan, S C ^a   Belentani, R M ^a   Marques, L C ^a   Silva, E R ^a   Silva, M A ^a   Caparroz Assef, S M ^a   Cuman, R K N ^a   Bersani Amado, C A ^a  

^a University of Maringa   (Brazil)

Author keywords

Anti inflammatory properties; Corticosteroids; Devil's claw; Harpagophytum procumbens; Intraperitoneal route

Indexed keywords

CARRAGEENAN; CORTICOSTEROID; HARPAGOPHYTUM EXTRACT;

ADRENAL GLAND; ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORTICOSTEROID RELEASE; DRUG INHIBITION; HARPAGOPHYTUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERACTIVITY; INFLAMMATION; LEUKOCYTE; LEUKOCYTE COUNT; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; ADRENAL GLANDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; HARPAGOPHYTUM; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; LEUKOCYTES; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

ANIMALIA; HARPAGOPHYTUM PROCUMBENS;

EID: 33646578170     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2005.06.004     Document Type: Article

References (24)

1. Bruneton J. Pharmacognosy, Phytochemistry, Medical Plants (1995), Lavoisier Publishing, Paris
2. Chrubasik S., Junck H., Breitschwerdt H., Conradt C., and Zappe H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain; a randomized, placebo-controlled, double-blind study. Eur. J. Anaesthesiol. 16 (1999) 118-129
3. Der Marderosian A. The Review of Natural Products (1999), Facts and comparisons, St. Louis
4. Ernest E., and Chrubasik S. Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind-trials. Rheum. Dis. Clin. N. Am. 26 (2000) 13-27
5. Fox D.A. Cytokine blockade as new strategy to treat rheumatoid arthritis: inhibition of tumor necrosis factor. Arch. Intern. Med. 160 (2000) 37-44
6. Garcia-Leme J., and Schapoval E.E.S. Stimulation of the hypothalamo-pituitary-adrenal axis by compounds formed in inflamed tissue. Br. J. Pharmacol. 53 (1975) 75-83
7. Grahame R., and Robinson B.V. Devil's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann. Rheum. Dis. 40 (1981) 632
8. Green P.G., Miao F.J.P., Janig W., and Levine J.D. Negative feedback neuroendocrine control of the inflammatory response in rats. J. Neurosci. 15 (1995) 4678-4686
9. Haag-Berrurier M., Kuballa B., and Anton R. Dosage des glucoiridoïdes totaux dans la racine d'Harpagophytum procumbens DC. Plant. Méd. Phytothér. 12 (1979) 197-206
10. Lanhers M.C., Fleurentin J., Martin F., Vinche A., and Younos C. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med. 58 (1992) 117-123
11. Leblan D., Chantre P., and Fournié B. L'Harpagophyton in the treatment of hip and knee osteoarthritis. Rev. Rhum. 67 (2000) 634-640
12. Leung A.Y., and Foster S. Encyclopedia of common natural ingredients used in food, drugs, and cosmetics. second ed. (1996), Wiley, New York pp. 208-210
13. Macleod D.W., Revell P., and Robinson B.V. Investigation of Harpagophytum procumbens D.C. in the treatment of experimental inflammation and arthritis in the rat. Br. J. Pharmacol. 6 (1979) 140-141
14. Melby J., Egdahl R., and Spink W. Secretion and metabolism of cortisol after injection of endotoxin. J. Lab. Clin. Med. 56 (1960) 50-62
15. Moraes Fr., and Garcia-Leme J. Endogenous corticosteroids and insulina in acute inflammation. Microvasc. Res. 23 (1982) 281-293
16. Morberg G.P. Site of action of endotoxins on hypothalamic-pituitary-adrenal axis. Am. J. Physiol. 220 (1971) 397-400
17. Newall C.A., Anderson L.A., and Philiiipson D.J. Herbal Medicines: A Guide for Health-Care Professionals (1996), The Pharmaceutical Press, London
18. Schulz V., Hänsel R., and Tyler R.E. Rational Phytotherapy: A Physicians'Guide to Herbal Medicine (1998), Springer, New York
19. Sofia R.D., Nalepa S.D., Harakal J.J., and Vassar H.B. Antiedema and analgesic propreties of d-9-tetrahydrocannabinol (THC). J. Pharmacol. Exp. Ther. 186 (1973) 646-655
20. Soulimani R., Younos C., Mortier F., and Derrieu C. The role of stomachal digestion on the pharmacological activity of plant extracts, using as an example extracts of Harpagophytum procumbens. Can. J. Physiol. Pharmacol. 72 (1994) 1532-1536
21. Van Haelen M. La biochimie et l'activité d'Harpagophytum procumbens DC. J. Pharm. Belg. 41 (1986) 172-182
22. Voigt R. Pharmazeutische Technologie. 7th ed. (1993), Ullstein Molsby, Berlin
23. Winter C.A., Risley E.A., and Nuss G.V. Carragenin-induced edema in the hindpaw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547
24. Whitehouse L.W., Znamirowska M., and Paul C.J. Devil's claw (Harpagphytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease. Can. Med. Assoc. J. 129 (1983) 249-251