PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines

Journal of Molecular Signaling

Volumn 2, Issue , 2007, Pages

  Que, Jianwen ^a   Lian, Qizhou ^a   El Oakley, Reida M ^a   Lim, Bing ^b,c   Lim, Sai Kiang ^d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 35649016567     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-2-9     Document Type: Article

References (49)

1. Keller G Embryonic stem cell differentiation: Emergence of a new era in biology and medicine Genes Dev 2005, 19:1129-55. 10.1101/gad.1303605 15905405
2. Wobus AM Boheler KR Embryonic stem cells: Prospects for developmental biology and cell therapy Physiol Rev 2005, 85:635-78. 10.1152/ physrev.00054.2003 15788707
3. Lian Q Yeo K Que J Tan E Yu F Yin Y Salto-Tellez M Oakley RM Lim SK Establishing Clonal Cell Lines with Endothelial-Like Potential from CD9, SSEA-1 Cells in Embryonic Stem Cell-Derived Embryoid Bodies PLoS ONE 2006, 1:e6. 1762397 17183690 10.1371/journal.pone.0000006
4. Yin Y Que J Teh M Cao WP El Oakley RM Lim S-K Embryonic Cell Lines with Endothelial Potential: An In Vitro System for Studying Endothelial Differentiation Arterioscler Thromb Vasc Biol 2004, 24:691-696. 10.1161/ 01.ATV.0000120375.51196.73 14764422
5. Richardson CJ Schalm SS Blenis J PI3-kinase and TOR: PIKTORing cell growth Semin Cell Dev Biol 2004, 15:147-59. 10.1016/j.semcdb.2003.12.023 15209374
6. Chang F Steelman LS Shelton JG Lee JT Navolanic PM Blalock WL Franklin R McCubrey JA Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review) Int J Oncol 2003, 22:469-80. 12579299
7. Haugland RP Probes for Live-Cell Function Handbook of fluorescent probes and research chemicals Eugene: Molecular Probes, Inc Spence MT Sixth 1996, 377:392.
8. Lawrence JC Lin TA McMahon LP Choi KM Modulation of the protein kinase activity of mTOR Curr Top Microbiol Immunol 2004, 279:199-213. 14560959
9. Fingar DC Richardson CJ Tee AR Cheatham L Tsou C Blenis J mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/ eukaryotic translation initiation factor 4E Mol Cell Biol 2004, 24:200-16. 303352 14673156 10.1128/MCB.24.1.200-216.2004
10. Fingar DC Blenis J Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression Oncogene 2004, 23:3151-71. 10.1038/sj.onc.1207542 15094765
11. SchmelzleT Hall MN TOR, a central controller of cell growth Cell 2000, 103:253. 62 10.1016/S0092-8674(00)00117-3 11057898
12. Inoki K Li Y Zhu T Wu J Guan KL TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat Cell Biol 2002, 4:648-57. 10.1038/ ncb839 12172553
13. Wang L Proud CG Ras/Erk Signaling Is Essential for Activation of Protein Synthesis by Gq Protein-Coupled Receptor Agonists in Adult Cardiomyocytes Circ Res 2002. 91:821-829. 10.1161/ 01.RES.0000041029.97988.E9 12411397
14. Nguyen KA Santos SJ Kreidel MK Diaz AL Rey R Lawson MA Acute Regulation of Translation Initiation by Gonadotropin-Releasing Hormone in the Gonadotrope Cell Line L{beta}T2 Mol Endocrinol 2004, 18:1301-1312. 10.1210/me.2003-0478 14752057
15. Lenormand P McMahon M Pouyssegur J Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway J Biol Chem 1996, 271:15762-8. 10.1074/jbc.271.26.15762 8663120
16. Yamakawa T Tanaka S Numaguchi K Yamakawa Y Motley ED Ichihara S Inagami T Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells Hypertension 2000, 35:313-8. 10642317
17. Kleijn M Korthout MM Voorma HO Thomas AA Phosphorylation of the eIF4E-binding protein PHAS-I after exposure of PC12 cells to EGF and NGF FEBS Lett 1996, 396:165-71. 10.1016/0014-5793(96)01097-6 8914981
18. Rocic P Jo H Lucchesi PA A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle Am J Physiol Cell Physiol 2003, 285:C1437-44. 12890645
19. Voisin L Foisy S Giasson E Lambert C Moreau P Meloche S EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors Am J Physiol Cell Physiol 2002, 283:C446-55. 12107054
20. Kelleher RJ 3rd Govindarajan A Jung HY Kang H Tonegawa S Translational control by MAPK signaling in long-term synaptic plasticity and memory Cell 2004, 116:467-79. 10.1016/S0092-8674(04)00115-1 15016380
21. Shahbazian D Roux PP Mieulet V Cohen MS Raught B Taunton J Hershey JW Blenis J Pende M Sonenberg N The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity Embo J 2006, 25:2781-91. 1500846 16763566 10.1038/sj.emboj.7601166
22. Gingras AC Raught B Sonenberg N mTOR signaling to translation Curr Top Microbiol Immunol 2004, 279:169-97. 14560958
23. Stacey DW Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells Curr Opin Cell Biol 2003, 15:158-63. 10.1016/ S0955-0674(03)00008-5 12648671
24. Ekholm SV Reed SI Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle Curr Opin Cell Biol 2000, 12:676-84. 10.1016/ S0955-0674(00)00151-4 11063931
25. Sherr CJ Roberts JM CDK inhibitors: Positive and negative regulators of G1-phase progression Genes Dev 1999, 13:1501-12. 10385618
26. Takuwa N Fukui Y Takuwa Y Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts Molecular And Cellular Biology 1999, 19(2):1346-1358.
27. Muise-Helmericks RC Grimes HL Bellacosa A Malstrom SE Tsichlis PN Rosen N Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway J Biol Chem 1998, 273:29864-29872. 10.1074/jbc.273.45.29864 9792703
28. Beitz JG Kim IS Calabresi P Frackelton AR Jr Human microvascular endothelial cells express receptors for platelet-derived growth factor Proc Natl Acad Sci USA 1991, 88:2021-5. 51158 1848018 10.1073/ pnas.88.5.2021
29. Beitz JG Kim IS Calabresi P Frackelton AR Jr Receptors for platelet-derived growth factor on microvascular endothelial cells Exs 1992, 61:85-90. 1319780
30. Marx M Perlmutter RA Madri JA Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis J Clin Invest 1994, 93:131-9. 293745 7506710
31. Sato TN Tozawa Y Deutsch U Wolburg-Buchholz K Fujiwara Y Gendron-Maguire M Gridley T Wolburg H Risau W Qin Y Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation Nature 1995, 376:70-4. 10.1038/376070a0 7596437
32. Breier G Damert A Plate KH Risau W Angiogenesis in embryos and ischemic diseases Thromb Haemost 1997, 78:678-83. 9198238
33. Ostman A PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma Cytokine Growth Factor Rev 2004, 15:275-86. 10.1016/j.cytogfr.2004.03.002 15207817
34. Takahashi K Murakami M Yamanaka S Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells Biochem Soc Trans 2005, 33:1522-5. 10.1042/BST20051522 16246160
35. Martin KA Rzucidlo EM Merenick BL Fingar DC Brown DJ Wagner RJ Powell RJ The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation Am J Physiol Cell Physiol 2004, 286:C507-17. 10.1152/ ajpcell.00201.2003 14592809
36. Rajan P Panchision DM Newell LF McKay RD BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells J Cell Biol 2003, 161:911-21. 10.1083/jcb.200211021 12796477
37. Parent R Kolippakkam D Booth G Beretta L Mammalian Target of Rapamycin Activation Impairs Hepatocytic Differentiation and Targets Genes Moderating Lipid Homeostasis and Hepatocellular Growth Cancer Res 2007, 67:4337-4345. 10.1158/0008-5472.CAN-06-3640 17483347
38. Evdokimova V Ovchinnikov LP Sorensen PH Y-box binding protein 1: providing a new angle on translational regulation Cell Cycle 2006, 5:1143-7. 16721060
39. Qi JH Matsumoto T Huang K Olausson K Christofferson R Claesson-Welsh L Phosphoinositide 3 kinase is critical for survival, mitogenesis and migration but not for differentiation of endothelial cells Angiogenesis 1999, 3:371-80. 10.1023/A:1026565908445 14517417
40. Brader S Eccles SA Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis Tumori 2004, 90:2-8. 15143962
41. Tee AR Blenis J mTOR, translational control and human disease Semin Cell Dev Biol 2005, 16:29-37. 10.1016/j.semcdb.2004.11.005 15659337
42. Inoki K Corradetti MN Guan KL Dysregulation of the TSC-mTOR pathway in human disease Nat Genet 2005, 37:19-24. 10.1038/ng1494 15624019
43. Kobayashi T Minowa O Kuno J Mitani H Hino O Noda T Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice Cancer Res 1999, 59:1206-11. 10096549
44. Kwiatkowski DJ Zhang H Bandura JL Heiberger KM Glogauer M el-Hashemite N Onda H A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells Hum Mol Genet 2002, 11:525-34. 10.1093/hmg/11.5.525 11875047
45. El-Hashemite N Walker V Zhang H Kwiatkowski DJ Loss of Tsc1 or Tsc2 Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin Cancer Res 2003, 63:5173-5177. 14500340
46. bin Ali A Zhang Q Lim YK Fang D Retnam L Lim SK Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation Free Radic Biol Med 2003, 34:824-9. 10.1016/ S0891-5849(02)01436-3 12654470
47. Chomczynski P Sacchi N Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry 1987, 162:156-159. 10.1016/0003-2697(87)90021-2 2440339
48. Caruccio N Ross J Purification of a human polyribosome-associated 3′ to 5′ exoribonuclease J Biol Chem 1994, 269:31814-21. 7989354
49. Yin Y Lim YK Salto-Tellez M Ng SC Lin CS Lim SK AFP(+), ESC-Derived Cells Engraft and Differentiate into Hepatocytes in Vivo Stem Cells 2002, 20:338-346. 10.1634/stemcells. 20-4-338 12110703