메뉴 건너뛰기




Volumn 67, Issue 9, 2007, Pages 4337-4345

Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CCAAT ENHANCER BINDING PROTEIN ALPHA; INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; RAPAMYCIN; RETINOID X RECEPTOR BETA; TUMOR NECROSIS FACTOR;

EID: 34249304441     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3640     Document Type: Article
Times cited : (36)

References (46)
  • 1
    • 20344369061 scopus 로고    scopus 로고
    • Prognostic prediction in patients with hepatocellular carcinoma
    • Sala M, Forner A, Varela M. Bruix J. Prognostic prediction in patients with hepatocellular carcinoma. Semin Liver His 2005;25:171-80.
    • (2005) Semin Liver His , vol.25 , pp. 171-180
    • Sala, M.1    Forner, A.2    Varela, M.3    Bruix, J.4
  • 2
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Molecular pathways and new therapeutic targets
    • Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver His 2005;25:212-25.
    • (2005) Semin Liver His , vol.25 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 3
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • Lee JS, Thorgeirsson SS. Comparative and integrative functional genomics of HCC. Oncogene 2006;25:3801-9.
    • (2006) Oncogene , vol.25 , pp. 3801-3809
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 4
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-83.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 5
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 6
    • 17944368972 scopus 로고    scopus 로고
    • An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
    • Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A 2001;98:10320-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10320-10325
    • Podsypanina, K.1    Lee, R.T.2    Politis, C.3
  • 7
    • 0030066934 scopus 로고    scopus 로고
    • Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
    • Beretta L, Gingras AC, Svitkin YV, Hall MN, Sonenberg N. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J 1996;15:658-64.
    • (1996) EMBO J , vol.15 , pp. 658-664
    • Beretta, L.1    Gingras, A.C.2    Svitkin, Y.V.3    Hall, M.N.4    Sonenberg, N.5
  • 10
    • 1842531162 scopus 로고    scopus 로고
    • Origin and characterization of a human bipotent liver progenitor cell line
    • Parent R, Marion MJ, Furio L, Trepo C, Petit MA. Origin and characterization of a human bipotent liver progenitor cell line. Gastroenterology 2004;126:1147-56.
    • (2004) Gastroenterology , vol.126 , pp. 1147-1156
    • Parent, R.1    Marion, M.J.2    Furio, L.3    Trepo, C.4    Petit, M.A.5
  • 11
    • 0037180522 scopus 로고    scopus 로고
    • Infection of a human hepatoma cell line by hepatitis B virus
    • Gripon P, Rumin S, Urban S, et al. Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A 2002;99:15655-60.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15655-15660
    • Gripon, P.1    Rumin, S.2    Urban, S.3
  • 12
    • 29344463279 scopus 로고    scopus 로고
    • Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line
    • Troadec MB, Glaise D, Lamtrault G, et al. Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line. Genomics 2006;87:93-103.
    • (2006) Genomics , vol.87 , pp. 93-103
    • Troadec, M.B.1    Glaise, D.2    Lamtrault, G.3
  • 13
    • 0037151120 scopus 로고    scopus 로고
    • Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics
    • Grolleau A, Bowman J, Pradet-Balade B, et al. Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J Biol Chem 2002;277:22175-84.
    • (2002) J Biol Chem , vol.277 , pp. 22175-22184
    • Grolleau, A.1    Bowman, J.2    Pradet-Balade, B.3
  • 14
    • 0034234924 scopus 로고    scopus 로고
    • A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
    • Sekulic A, Hudson CC, Homme JL, et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000;60:3504-13.
    • (2000) Cancer Res , vol.60 , pp. 3504-3513
    • Sekulic, A.1    Hudson, C.C.2    Homme, J.L.3
  • 17
    • 0035192915 scopus 로고    scopus 로고
    • Ezrinradixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia
    • Fouassier L, Duan CY, Feranchak AP, et al. Ezrinradixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia. Hepatology 2001;33:166-76.
    • (2001) Hepatology , vol.33 , pp. 166-176
    • Fouassier, L.1    Duan, C.Y.2    Feranchak, A.P.3
  • 18
    • 78651053628 scopus 로고
    • Primary carcinoma of the liver; a study of 100 cases among 48,900 necropsies
    • Edmondson HA, Steiner PE. Primary carcinoma of the liver; a study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
    • (1954) Cancer , vol.7 , pp. 462-503
    • Edmondson, H.A.1    Steiner, P.E.2
  • 19
    • 30444434212 scopus 로고    scopus 로고
    • Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation
    • Song K, Wang H, Krebs TL, Danielpour D, Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation. EMBO J 2006;25:58-69.
    • (2006) EMBO J , vol.25 , pp. 58-69
    • Song, K.1    Wang, H.2    Krebs, T.L.3    Danielpour, D.4
  • 20
    • 33747064112 scopus 로고    scopus 로고
    • Fooling the Fas ligand in death
    • Rodrigues CM, Steer CJ. Fooling the Fas ligand in death. Hepatology 2006;44:314-7.
    • (2006) Hepatology , vol.44 , pp. 314-317
    • Rodrigues, C.M.1    Steer, C.J.2
  • 21
    • 14244267810 scopus 로고    scopus 로고
    • IF116 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
    • Kim EJ, Park JI, Nelkin BD. IF116 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. J Biol Chem 2005;280:4913-20.
    • (2005) J Biol Chem , vol.280 , pp. 4913-4920
    • Kim, E.J.1    Park, J.I.2    Nelkin, B.D.3
  • 22
    • 2442494082 scopus 로고    scopus 로고
    • Requirement of IF116 for the maximal activation of p53 induced by ionizing radiation
    • Fujiuchi N, Aglipay JA, Ohtsuka T, et al. Requirement of IF116 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem 2004;279:20339-44.
    • (2004) J Biol Chem , vol.279 , pp. 20339-20344
    • Fujiuchi, N.1    Aglipay, J.A.2    Ohtsuka, T.3
  • 23
    • 0037016729 scopus 로고    scopus 로고
    • Molecular cross-talk between the TRAIL and interferon signaling pathways
    • Kumar-Sinha C, Varambally S, Sreekumar A, Chinnaiyan AM. Molecular cross-talk between the TRAIL and interferon signaling pathways. J Biol Chem 2002;277:575-85.
    • (2002) J Biol Chem , vol.277 , pp. 575-585
    • Kumar-Sinha, C.1    Varambally, S.2    Sreekumar, A.3    Chinnaiyan, A.M.4
  • 24
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004;116:205-19.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 25
    • 21644452212 scopus 로고    scopus 로고
    • Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling
    • Haouzi D, Baghdiguian S, Granier G, Travo P, Mangeat P, Hibner U. Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling. J Cell Sci 2005;118:2763-73.
    • (2005) J Cell Sci , vol.118 , pp. 2763-2773
    • Haouzi, D.1    Baghdiguian, S.2    Granier, G.3    Travo, P.4    Mangeat, P.5    Hibner, U.6
  • 26
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T. Peroxisome proliferator-activated receptor α-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem 1998;273:29577-85.
    • (1998) J Biol Chem , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6
  • 27
    • 12744267799 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: Role of peroxisome proliferator-activated receptor α
    • Crabb DW, Galli A, Fischer M, You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor α. Alcohol 2004;34:35-8.
    • (2004) Alcohol , vol.34 , pp. 35-38
    • Crabb, D.W.1    Galli, A.2    Fischer, M.3    You, M.4
  • 28
    • 14944374003 scopus 로고    scopus 로고
    • Impaired expression of the peroxisome proliferator-activated receptor a during hepatitis C virus infection
    • Dharancy S, Malapel M, Perlemuter G, et al. Impaired expression of the peroxisome proliferator-activated receptor a during hepatitis C virus infection. Gastroenterology 2005;128:334-42.
    • (2005) Gastroenterology , vol.128 , pp. 334-342
    • Dharancy, S.1    Malapel, M.2    Perlemuter, G.3
  • 29
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
    • Oliver WR, Jr., Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A 2001;98:5306-11.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5306-5311
    • Oliver Jr., W.R.1    Shenk, J.L.2    Snaith, M.R.3
  • 30
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor 6 induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
    • Tanaka T, Yamamoto J, Iwasaki S, et al. Activation of peroxisome proliferator-activated receptor 6 induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A 2003;100:15924-9.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15924-15929
    • Tanaka, T.1    Yamamoto, J.2    Iwasaki, S.3
  • 31
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor fi activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator-activated receptor fi activates fat metabolism to prevent obesity. Cell 2003;113:159-70.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3
  • 32
    • 33644766913 scopus 로고    scopus 로고
    • PPARδ regulates glucose metabolism and insulin sensitivity
    • Lee CH, Olson P, Hevener A, et al. PPARδ regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 2006;103:3444-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3444-3449
    • Lee, C.H.1    Olson, P.2    Hevener, A.3
  • 34
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    • Repa JJ, Turley SD, Lobaccaro JA, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000;289:1524-9.
    • (2000) Science , vol.289 , pp. 1524-1529
    • Repa, J.J.1    Turley, S.D.2    Lobaccaro, J.A.3
  • 35
    • 29144483458 scopus 로고    scopus 로고
    • Loss of function of retinoic acid in liver leads to steatohepatitis and liver tumor: A NASH animal model
    • Shiota G. Loss of function of retinoic acid in liver leads to steatohepatitis and liver tumor: a NASH animal model. Hepatol Res 2005;33:155-60.
    • (2005) Hepatol Res , vol.33 , pp. 155-160
    • Shiota, G.1
  • 36
    • 0032949466 scopus 로고    scopus 로고
    • Liver enriched transcription factors and differentiation of hepatocellular carcinoma
    • Hayashi Y, Wang W, Ninomiya T, Nagano H, Ohta K, Itoh H. Liver enriched transcription factors and differentiation of hepatocellular carcinoma. Mol Pathol 1999;52:19-24.
    • (1999) Mol Pathol , vol.52 , pp. 19-24
    • Hayashi, Y.1    Wang, W.2    Ninomiya, T.3    Nagano, H.4    Ohta, K.5    Itoh, H.6
  • 37
    • 0024711273 scopus 로고
    • Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein
    • Birkenmeier EH, Gwynn B, Howard S, et al. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989;3:1146-56.
    • (1989) Genes Dev , vol.3 , pp. 1146-1156
    • Birkenmeier, E.H.1    Gwynn, B.2    Howard, S.3
  • 38
    • 0030022255 scopus 로고    scopus 로고
    • Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein
    • Watkins PJ, Condreay JP, Huber BE, Jacobs SJ, Adams DJ. Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein. Cancer Res 1996;56:1063-7.
    • (1996) Cancer Res , vol.56 , pp. 1063-1067
    • Watkins, P.J.1    Condreay, J.P.2    Huber, B.E.3    Jacobs, S.J.4    Adams, D.J.5
  • 39
    • 28544438792 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein α knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma
    • Tan EH, Hooi SC, Laban M, et al. CCAAT/enhancer binding protein α knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res 2005;65:10330-7.
    • (2005) Cancer Res , vol.65 , pp. 10330-10337
    • Tan, E.H.1    Hooi, S.C.2    Laban, M.3
  • 40
    • 0344837364 scopus 로고    scopus 로고
    • Down-regulated expression of the CCAAT/enhancer binding protein a and P. genes in human hepatocellular carcinoma: A possible prognostic marker
    • Tomizawa M, Watanabe K, Saisho H, Nakagawara A, Tagawa M. Down-regulated expression of the CCAAT/enhancer binding protein a and P. genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res 2003;23:351-4.
    • (2003) Anticancer Res , vol.23 , pp. 351-354
    • Tomizawa, M.1    Watanabe, K.2    Saisho, H.3    Nakagawara, A.4    Tagawa, M.5
  • 41
    • 0029746172 scopus 로고    scopus 로고
    • Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein α
    • Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein α. J Biol Chem 1996;271:24753-60.
    • (1996) J Biol Chem , vol.271 , pp. 24753-24760
    • Flodby, P.1    Barlow, C.2    Kylefjord, H.3    Ahrlund-Richter, L.4    Xanthopoulos, K.G.5
  • 42
    • 0029160028 scopus 로고
    • Impaired energy homeostasis in C/EBPα knockout mice
    • Wang ND, Finegold MJ, Bradley A, et al. Impaired energy homeostasis in C/EBPα knockout mice. Science 1995;269:1108-12.
    • (1995) Science , vol.269 , pp. 1108-1112
    • Wang, N.D.1    Finegold, M.J.2    Bradley, A.3
  • 43
    • 33644685669 scopus 로고    scopus 로고
    • Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein α
    • Yang J, Croniger CM, Lekstrom-Himes J, et al. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein α. J Biol Chem 2005;280:38689-99.
    • (2005) J Biol Chem , vol.280 , pp. 38689-38699
    • Yang, J.1    Croniger, C.M.2    Lekstrom-Himes, J.3
  • 44
    • 33749072508 scopus 로고    scopus 로고
    • Blockage of HGF/c-Met system by gene therapy (adenovlrus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice
    • Son G, Hirano T, Seki E, et al. Blockage of HGF/c-Met system by gene therapy (adenovlrus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. J Hepatol 2006;45:688-95.
    • (2006) J Hepatol , vol.45 , pp. 688-695
    • Son, G.1    Hirano, T.2    Seki, E.3
  • 45
    • 0038363443 scopus 로고    scopus 로고
    • Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    • Cao R, Brakenhielm E, Pawliuk R, et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003;9:604-13.
    • (2003) Nat Med , vol.9 , pp. 604-613
    • Cao, R.1    Brakenhielm, E.2    Pawliuk, R.3
  • 46
    • 19944415267 scopus 로고    scopus 로고
    • Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma
    • Uematsu S, Higashi T, Nouso K, et al. Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 2005;20:583-8.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 583-588
    • Uematsu, S.1    Higashi, T.2    Nouso, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.