Microscopic kinetic determinants of macroscopic currents: Insights from coupling and uncoupling of GABAA receptor desensitization and deactivation

Journal of Physiology

Volumn 584, Issue 3, 2007, Pages 769-787

  Bianchi, Matt T ^a   Botzolakis, Emmanuel J ^b   Haas, Kevin F ^c   Fisher, Janet L ^d   Macdonald, Robert L ^b,c,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ION CHANNEL;

ALGORITHM; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE INACTIVATION; GENE MUTATION; GENETIC LINKAGE; GENETIC STABILITY; HUMAN; HUMAN CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE CURRENT; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN DOMAIN; BINDING AFFINITY; BINDING SITE; MICROSCOPY; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; RATE CONSTANT;

ADAPTATION, BIOLOGICAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GABA AGONISTS; HUMANS; ION CHANNEL GATING; KINETICS; MUTATION; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, GABA-A;

EID: 35648959194     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.142364     Document Type: Article

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