Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAA receptors

Journal of Neuroscience

Volumn 21, Issue 4, 2001, Pages 1127-1136

  Bianchi, Matt T ^a   Haas, Kevin F ^a   Macdonald, Robert L ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Concentration jump; Deactivation; Desensitization; GABAA receptor; Rapid kinetics; Recombinant

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE DEPOLARIZATION; NEUROTRANSMITTER RELEASE; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

EID: 0035866070     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-04-01127.2001     Document Type: Article

References (43)

1. Identifcation of acetylcholine receptor channel-lining residues in the M1 segment of the α-subunit
2. Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the a subunit
3. Homomeric ρl GABA channels: Activation properties and domains
4. A receptor subunits: Analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique
5. θ, a novel γ-aminobutyric acid type A receptor subunit
6. A receptor m outside-out patches
7. c receptor
8. A receptor
9. Transmitter timecourse in the synaptic cleft: Its role in central synaptic function
10. Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and the effects of mutating receptors
11. A receptors
12. A receptor subunit
13. A receptor desensitization: The role of the gamma2 subunit and its physiological significance
14. The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
15. A receptors containing γ2 of δ subtypes expressed with αl and β3 subtypes in mouse L929 cells
16. A receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons
17. A receptors in the transfected L929 cells isolated by immunomagnetic bead separation
18. A receptors in mouse fibroblasts
19. A receptor subunit in tissues of the reproductive system
20. A receptors
21. A channel responses to brief agonist pulses
22. The impact of receptor desensitization on fast synaptic transmission
23. A receptor assembly: Identification and structure of γ2 sequences forming the intersubunit contacts with al and β3 subunits
24. N-terminal domains in the NR2 subunit control desensitization of NMDA receptors
25. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
26. Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel
27. A receptor channels
28. A receptor main conductance state of mouse spinal cord neurones in culture
29. A receptors open?
30. A-receptor subtypes really occur in the brain?
31. A receptor determined by electron microscopic image analysis
32. Evolutionary history of the ligand-gated ion-channel superfamily of receptors
33. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
34. A receptor isoforms
35. A point mutation in the glutamate binding site blocks desensitization in AMPA receptors
36. A receptor a subunits that mediate specific assembly with receptor β subunits
37. A receptor alpha 6 subunit
38. A receptors
39. Acetylcholine receptor channel imaged in the open state
40. Glycine-independent NMDA receptor desensitization: Localization of structural determinants
41. The location of the gate in the acetylcholine receptor channel
42. A receptor al subunit
43. Single amino acid substitution affects desensitization kinetics of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes