The role of interface framework residues in determining antibody VH/VL interaction strength and antigen-binding affinity

FEBS Journal

Volumn 273, Issue 10, 2006, Pages 2184-2194

  Masuda, Kenji ^a   Sakamoto, Kenzo ^a   Kojima, Miki ^a   Aburatani, Takahide ^a   Ueda, Takuya ^a   Ueda, Hiroshi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Antibody variable region; Antigen antibody interaction; Combinatorial mutagenesis; Immunoassay; Phage display

Indexed keywords

ANTIBODY; LYSOZYME ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BIOSENSOR; CODON; GENE MUTATION; PHAGE DISPLAY; PHAGEMID; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIGENS; BINDING SITES, ANTIBODY; CELLS, CULTURED; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PEPTIDE LIBRARY;

EID: 33646260476     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05232.x     Document Type: Article

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