Domain interactions in the Fab fragment: A comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

Journal of Molecular Biology

Volumn 347, Issue 4, 2005, Pages 773-789

  Röthlisberger, Daniela ^a   Honegger, Annemarie ^a   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Antibody fragment; Domain interaction; Mutual stabilization

Indexed keywords

DISULFIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; COMPARATIVE STUDY; DISULFIDE BOND; KINETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN INTERACTION; PROTEIN STABILITY; THERMODYNAMICS; THERMOSTABILITY; TIME;

EID: 14844339334     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.01.053     Document Type: Article

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