K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2670-2675

  Sheng, H ^a   Shao, J ^a   DuBois, R N ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; EPITHELIUM CELL; GENE MUTATION; GENETIC TRANSFECTION; INTESTINE EPITHELIUM; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; ENZYME ACTIVATION; ENZYME INDUCTION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, RAS; INTESTINAL MUCOSA; ISOENZYMES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; RATS; RNA, MESSENGER; TRANSFECTION;

EID: 0035866755     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ras oncogenes in human cancer: A review
2. Activators and effectors of ras p21 proteins
3. Mitogen-activated protein kinase pathways
4. Critical role of Rho in cell transformation by oncogenic Ras
5. Signal transduction from multiple Ras effectors
6. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
7. Differential roles of Akt, Rac, and Ra1 in R-Ras-mediated cellular transformation, adhesion, and survival
8. Overexpression of c-K-ras, c-N-ras and transforming growth factor β co-segregate with tumorigenicity in morphologically transformed C3H 10T1/2 cell lines
9. Overexpression of H-ras oncogene induces resistance to the growth-inhibitory action of transforming growth factor β-1 (TGF-β1) and alters the number and type of TGF-β 1 receptors in rat intestinal epithelial cell clones
10. TGF-β1 enhances Ha-Ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
11. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway
12. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
13. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
14. 2 in human colon cancer cells
15. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
16. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
17. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
18. Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma
19. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
20. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
21. CREB is a regulatory target for the protein kinase Akt/PKB
22. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
23. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
24. Induction of NF-κB by the Akt/PKB kinase
25. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
26. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
27. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
28. A selective cyclooxygenase-2 inhibitor suppresses the growth of H-ras transformed rat intestinal epithelial cells
29. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element
30. Post-transcriptional control of cyclooxygenase-2 gene expression: The role of the 3′ untranslated region
31. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells
32. An essential role for Rac in Ras transformation
33. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum
34. Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells
35. Ceramide regulates the transcription of cyclooxygenase-2
36. Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells