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Volumn 26, Issue 47, 2007, Pages 6829-6837

Transcriptional dysregulation during myeloid transformation in AML

Author keywords

AML; CEBPA; Myeloid differentiation; PU.1; RUNX1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; HYBRID PROTEIN; RNA BINDING PROTEIN;

EID: 35348908269     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210765     Document Type: Review
Times cited : (85)

References (78)
  • 1
    • 34147161800 scopus 로고    scopus 로고
    • Five members of the CEBP transcription factor family are targeted by recurrent IGH-translocations in B-cell precursor acute lymphoblastic leukemia (BC-ALL)
    • Akasaka T, Balasa T, Russell LJ, Sugimoto KJ, Majid A, Walewska R et al. (2007). Five members of the CEBP transcription factor family are targeted by recurrent IGH-translocations in B-cell precursor acute lymphoblastic leukemia (BC-ALL). Blood 109: 3451-3461.
    • (2007) Blood , vol.109 , pp. 3451-3461
    • Akasaka, T.1    Balasa, T.2    Russell, L.J.3    Sugimoto, K.J.4    Majid, A.5    Walewska, R.6
  • 2
    • 0037591396 scopus 로고    scopus 로고
    • Barjesteh van Waalwijk van Doorn-Khosrovani SB, Erpelnick C, Meijer J, Oosterhoud S, van Putten WL, Valk PJ et al. (2003). Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J 4: 31-40.
    • Barjesteh van Waalwijk van Doorn-Khosrovani SB, Erpelnick C, Meijer J, Oosterhoud S, van Putten WL, Valk PJ et al. (2003). Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J 4: 31-40.
  • 3
    • 16744363992 scopus 로고    scopus 로고
    • Ras signaling enhances the ability of CEBPA to induce granulocytic differentiation by phosphorylation of serine 248
    • Behre G, Singh SM, Liu H, Bortolin LT, Christopeit M, Radomska HS et al. (2002). Ras signaling enhances the ability of CEBPA to induce granulocytic differentiation by phosphorylation of serine 248. J Biol Chem 277: 26293-26299.
    • (2002) J Biol Chem , vol.277 , pp. 26293-26299
    • Behre, G.1    Singh, S.M.2    Liu, H.3    Bortolin, L.T.4    Christopeit, M.5    Radomska, H.S.6
  • 5
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L, Dohner K, Bair E, Frohling S, Schlenk RF, Tibshirani R et al. (2004). Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 350: 1605-1616.
    • (2004) N Engl J Med , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Dohner, K.2    Bair, E.3    Frohling, S.4    Schlenk, R.F.5    Tibshirani, R.6
  • 6
    • 33751196596 scopus 로고    scopus 로고
    • Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
    • Chapiro E, Russell L, Radford-Weiss I, Bastard C, Lessard M, Struski S et al. (2006). Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia. Blood 108: 3560-3563.
    • (2006) Blood , vol.108 , pp. 3560-3563
    • Chapiro, E.1    Russell, L.2    Radford-Weiss, I.3    Bastard, C.4    Lessard, M.5    Struski, S.6
  • 7
    • 0036456441 scopus 로고    scopus 로고
    • Infrequent hypermethylation of CEBPA promoter in acute myeloid leukaemia
    • Chim CS, Wong ASY, Kwong YL. (2002). Infrequent hypermethylation of CEBPA promoter in acute myeloid leukaemia. Br J Haematol 119: 988-990.
    • (2002) Br J Haematol , vol.119 , pp. 988-990
    • Chim, C.S.1    Wong, A.S.Y.2    Kwong, Y.L.3
  • 8
    • 9444287619 scopus 로고    scopus 로고
    • PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
    • Cook WD, McCaw BJ, Herring C, John DL, Foote SJ, Nutt SL et al. (2004). PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain. Blood 104: 3437-3444.
    • (2004) Blood , vol.104 , pp. 3437-3444
    • Cook, W.D.1    McCaw, B.J.2    Herring, C.3    John, D.L.4    Foote, S.J.5    Nutt, S.L.6
  • 9
    • 0242389807 scopus 로고    scopus 로고
    • C/EBPβ: A major PML-RARA-responsive gene in retinoic acid-induced differentiation in APL cells
    • Duprez E, Wagner K, Koch H, Tenen DG. (2003). C/EBPβ: a major PML-RARA-responsive gene in retinoic acid-induced differentiation in APL cells. EMBO J 22: 5806-5818.
    • (2003) EMBO J , vol.22 , pp. 5806-5818
    • Duprez, E.1    Wagner, K.2    Koch, H.3    Tenen, D.G.4
  • 10
    • 33745161658 scopus 로고    scopus 로고
    • Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by CEBPA
    • Ferrari-Amorotti G, Keeshan K, Zattoni M, Guerzoni C, Iotti G, Cattelani S et al. (2006). Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by CEBPA. Blood 108: 1353-1363.
    • (2006) Blood , vol.108 , pp. 1353-1363
    • Ferrari-Amorotti, G.1    Keeshan, K.2    Zattoni, M.3    Guerzoni, C.4    Iotti, G.5    Cattelani, S.6
  • 11
    • 0037071397 scopus 로고    scopus 로고
    • Transcriptional control of granulocyte and monocyte development
    • Friedman A. (2002). Transcriptional control of granulocyte and monocyte development. Oncogene 21: 3377-3390.
    • (2002) Oncogene , vol.21 , pp. 3377-3390
    • Friedman, A.1
  • 12
    • 13944257378 scopus 로고    scopus 로고
    • Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations
    • Frohling S, Schlenk RF, Krauter J, Chiede C, Ehninger G, Haase D et al. (2005). Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations. Genes Chromosomes Cancer 42: 427-432.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 427-432
    • Frohling, S.1    Schlenk, R.F.2    Krauter, J.3    Chiede, C.4    Ehninger, G.5    Haase, D.6
  • 13
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Brenner A, Kreitmeier S et al. (2004). CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 22: 624-633.
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3    Bihlmayr, J.4    Brenner, A.5    Kreitmeier, S.6
  • 14
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart AF, Hofmann WK, Kawano S, Takeuchi S, Krug U, Kwok SH et al. (2002). Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood 99: 1332-1340.
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1    Hofmann, W.K.2    Kawano, S.3    Takeuchi, S.4    Krug, U.5    Kwok, S.H.6
  • 15
    • 0037438508 scopus 로고    scopus 로고
    • Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia
    • Harada H, Harada Y, Tanaka H, Kimura A, Inaba T. (2003). Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood 101: 673-680.
    • (2003) Blood , vol.101 , pp. 673-680
    • Harada, H.1    Harada, Y.2    Tanaka, H.3    Kimura, A.4    Inaba, T.5
  • 16
    • 33846217297 scopus 로고    scopus 로고
    • Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia
    • Healy J, Bélanger H, Beaulieu P, Larivière M, Lauda D, Sinnett D. (2007). Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Blood 109: 683-692.
    • (2007) Blood , vol.109 , pp. 683-692
    • Healy, J.1    Bélanger, H.2    Beaulieu, P.3    Larivière, M.4    Lauda, D.5    Sinnett, D.6
  • 17
    • 4444233646 scopus 로고    scopus 로고
    • C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
    • Heath V, Suh HC, Holman M, Renn K, Gooya JM, Parkin S et al. (2004). C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104: 1639-1647.
    • (2004) Blood , vol.104 , pp. 1639-1647
    • Heath, V.1    Suh, H.C.2    Holman, M.3    Renn, K.4    Gooya, J.M.5    Parkin, S.6
  • 19
    • 23744483486 scopus 로고    scopus 로고
    • CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)
    • Helbling D, Mueller BU, Timchenko NA, Schardt J, Eyer M, Betts DR et al. (2005). CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood 106: 1369-1375.
    • (2005) Blood , vol.106 , pp. 1369-1375
    • Helbling, D.1    Mueller, B.U.2    Timchenko, N.A.3    Schardt, J.4    Eyer, M.5    Betts, D.R.6
  • 21
    • 33751073965 scopus 로고    scopus 로고
    • Tribbles homolog 2 inactivates CEBPA and causes acute myelogenous leukemia
    • Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H et al. (2006). Tribbles homolog 2 inactivates CEBPA and causes acute myelogenous leukemia. Cancer Cell 10: 401-411.
    • (2006) Cancer Cell , vol.10 , pp. 401-411
    • Keeshan, K.1    He, Y.2    Wouters, B.J.3    Shestova, O.4    Xu, L.5    Sai, H.6
  • 23
    • 33749317297 scopus 로고    scopus 로고
    • CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities
    • Lee YL, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan S. (2006). CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood 108: 2416-2419.
    • (2006) Blood , vol.108 , pp. 2416-2419
    • Lee, Y.L.1    Jones, L.C.2    Timchenko, N.A.3    Perrotti, D.4    Tenen, D.G.5    Kogan, S.6
  • 24
    • 20044388101 scopus 로고    scopus 로고
    • Characterization of CEBPA mutations in acute myeloid leukemia: Most patients with CEBPA mutations have biallelic mutations and show distinct immunopheno-type of the leukemic cells
    • Lin LI, Chen CY, Lin DT, Tsay W, Tang JL, Yeh JY et al. (2005). Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show distinct immunopheno-type of the leukemic cells. Clin Cancer Res 11: 1372-1379.
    • (2005) Clin Cancer Res , vol.11 , pp. 1372-1379
    • Lin, L.I.1    Chen, C.Y.2    Lin, D.T.3    Tsay, W.4    Tang, J.L.5    Yeh, J.Y.6
  • 25
    • 0037926888 scopus 로고    scopus 로고
    • Reciprocal effects of C/EBPα and PKCδ on JunB expression and monocytic differentiation depend upon the C/EBPα basic region
    • Liu H, Keefer JR, Wang QF, Friedman AD. (2003). Reciprocal effects of C/EBPα and PKCδ on JunB expression and monocytic differentiation depend upon the C/EBPα basic region. Blood 101: 3885-3892.
    • (2003) Blood , vol.101 , pp. 3885-3892
    • Liu, H.1    Keefer, J.R.2    Wang, Q.F.3    Friedman, A.D.4
  • 26
    • 9144270483 scopus 로고    scopus 로고
    • Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype
    • Matsuno NMO, Osato M, Yamashita N, Yanagida M, Nanri T, Fukushima T et al. (2003). Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype. Leukemia 17: 2492-2499.
    • (2003) Leukemia , vol.17 , pp. 2492-2499
    • Matsuno, N.M.O.1    Osato, M.2    Yamashita, N.3    Yanagida, M.4    Nanri, T.5    Fukushima, T.6
  • 27
    • 33745860708 scopus 로고    scopus 로고
    • Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein α
    • McFie PJ, Wang GL, Timchenko NA, Wilson HL, Hu X, Roesler WJ. (2006). Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein α. J Biol Chem 281: 18069-18080.
    • (2006) J Biol Chem , vol.281 , pp. 18069-18080
    • McFie, P.J.1    Wang, G.L.2    Timchenko, N.A.3    Wilson, H.L.4    Hu, X.5    Roesler, W.J.6
  • 28
    • 31944450531 scopus 로고    scopus 로고
    • Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
    • Metcalf D, Dakic A, Mifsud S, Di Rago L, Wu L, Nutt S. (2006). Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia. Proc Natl Acad Sci USA 103: 1486-1491.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1486-1491
    • Metcalf, D.1    Dakic, A.2    Mifsud, S.3    Di Rago, L.4    Wu, L.5    Nutt, S.6
  • 29
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific FLT3 mutations
    • Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B et al. (2003). Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific FLT3 mutations. Blood 101: 3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3    Choudhary, C.4    Agrawal, S.5    Sargin, B.6
  • 30
    • 33644836787 scopus 로고    scopus 로고
    • CEBPA and the pathophysiology of acute myeloid leukemia (AML)
    • Mueller BU, Pabst T. (2006). CEBPA and the pathophysiology of acute myeloid leukemia (AML). Curr Opin Hematol 13: 7-14.
    • (2006) Curr Opin Hematol , vol.13 , pp. 7-14
    • Mueller, B.U.1    Pabst, T.2
  • 31
    • 33645734361 scopus 로고    scopus 로고
    • ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression
    • Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N et al. (2006a). ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression. Blood 107: 3330-3338.
    • (2006) Blood , vol.107 , pp. 3330-3338
    • Mueller, B.U.1    Pabst, T.2    Fos, J.3    Petkovic, V.4    Fey, M.F.5    Asou, N.6
  • 32
    • 33745115403 scopus 로고    scopus 로고
    • Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia
    • Mueller BU, Pabst T, Hauser P, Neuberg D, Tenen DG. (2006b). Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia. Br J Cancer 94: 1918-1920.
    • (2006) Br J Cancer , vol.94 , pp. 1918-1920
    • Mueller, B.U.1    Pabst, T.2    Hauser, P.3    Neuberg, D.4    Tenen, D.G.5
  • 33
    • 0036682473 scopus 로고    scopus 로고
    • Heterozygous PU.1 mutations are associated with acute myeloid leukemia
    • Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD et al. (2002). Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood 100: 998-1007.
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1    Pabst, T.2    Osato, M.3    Asou, N.4    Johansen, L.M.5    Minden, M.D.6
  • 34
    • 0032984118 scopus 로고    scopus 로고
    • Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
    • Nagata T, Gupta V, Sorce D, Kim WY, Sali A, Chait BT et al. (1999). Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain. Nat Struct Biol 6: 615-619.
    • (1999) Nat Struct Biol , vol.6 , pp. 615-619
    • Nagata, T.1    Gupta, V.2    Sorce, D.3    Kim, W.Y.4    Sali, A.5    Chait, B.T.6
  • 35
    • 35348838187 scopus 로고    scopus 로고
    • A pedigree harbouring a germ-line N-terminal C/EBPα mutation and development of acute myeloblastic leukemia with a somatic C-terminal C/EBPα mutation
    • Nanri T, Uike N, Kawakita T, Iwanaga E, Hoshino K, Mitsuya H et al. (2006). A pedigree harbouring a germ-line N-terminal C/EBPα mutation and development of acute myeloblastic leukemia with a somatic C-terminal C/EBPα mutation. Blood 108: 543A.
    • (2006) Blood , vol.108
    • Nanri, T.1    Uike, N.2    Kawakita, T.3    Iwanaga, E.4    Hoshino, K.5    Mitsuya, H.6
  • 36
    • 2942667930 scopus 로고    scopus 로고
    • Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
    • Osato M. (2004). Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 23: 4284-4296.
    • (2004) Oncogene , vol.23 , pp. 4284-4296
    • Osato, M.1
  • 37
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias
    • Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Era T et al. (1999). Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 93: 1817-1824.
    • (1999) Blood , vol.93 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3    Hoshino, K.4    Yamasaki, H.5    Era, T.6
  • 38
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor CEBPA in t(8;21) myeloid leukemia
    • Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G et al. (2001a). AML1-ETO downregulates the granulocytic differentiation factor CEBPA in t(8;21) myeloid leukemia. Nat Med 7: 444-451.
    • (2001) Nat Med , vol.7 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3    Schoch, C.4    Haferlach, T.5    Behre, G.6
  • 39
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (CEBPA), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S et al. (2001b). Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (CEBPA), in acute myeloid leukemia. Nat Genet 27: 263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6
  • 40
    • 33645823399 scopus 로고    scopus 로고
    • Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia
    • Pabst T, Stillner E, Neuberg D, Nimer S, Willman CL, List AF et al. (2006). Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia. Br J Haematol 133: 400-402.
    • (2006) Br J Haematol , vol.133 , pp. 400-402
    • Pabst, T.1    Stillner, E.2    Neuberg, D.3    Nimer, S.4    Willman, C.L.5    List, A.F.6
  • 41
    • 0037189579 scopus 로고    scopus 로고
    • Regulation of CCAAT/enhancer binding protein (C/EBP) activator proteins by heterodimerization with C/EBPγ(Ig/EBP)
    • Parkin SE, Baer M, Copeland TD, Schwartz RC, Johnson PF. (2002). Regulation of CCAAT/enhancer binding protein (C/EBP) activator proteins by heterodimerization with C/EBPγ(Ig/EBP). J Biol Chem 277: 23563-23572.
    • (2002) J Biol Chem , vol.277 , pp. 23563-23572
    • Parkin, S.E.1    Baer, M.2    Copeland, T.D.3    Schwartz, R.C.4    Johnson, P.F.5
  • 42
    • 7444235907 scopus 로고    scopus 로고
    • Cis-acting regulatory variation in the human genome
    • Pastinen T, Hudson TJ. (2004). Cis-acting regulatory variation in the human genome. Science 306: 647-650.
    • (2004) Science , vol.306 , pp. 647-650
    • Pastinen, T.1    Hudson, T.J.2
  • 44
    • 22344437854 scopus 로고    scopus 로고
    • Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocytic lineage
    • Porse BT, Bryder D, Theilgaard-Mönch K, Hasemann MS, Anderson K, Damgaard I et al. (2005). Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocytic lineage. J Exp Med 202: 85-96.
    • (2005) J Exp Med , vol.202 , pp. 85-96
    • Porse, B.T.1    Bryder, D.2    Theilgaard-Mönch, K.3    Hasemann, M.S.4    Anderson, K.5    Damgaard, I.6
  • 45
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by CEBPA is required for adipogenesis and granulopoiesis in vivo
    • Porse BT, Pedersen TA, Xu X, Lindberg B, Wewer UM et al. (2001). E2F repression by CEBPA is required for adipogenesis and granulopoiesis in vivo. Cell 107: 247-258.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1    Pedersen, T.A.2    Xu, X.3    Lindberg, B.4    Wewer, U.M.5
  • 46
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C, Sagot C, Boissel N, Cayuela JM, Tigaud I, de Botton S et al. (2002). Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100: 2717-2723.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3    Cayuela, J.M.4    Tigaud, I.5    de Botton, S.6
  • 47
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, Lai JL et al. (2000). High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 96: 2862-2869.
    • (2000) Blood , vol.96 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3    Grardel-Duflos, N.4    Garand, R.5    Lai, J.L.6
  • 48
    • 33344455424 scopus 로고    scopus 로고
    • Block of CEBPA function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
    • Radomska HS, Basseres DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y et al. (2006). Block of CEBPA function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med 203: 371-381.
    • (2006) J Exp Med , vol.203 , pp. 371-381
    • Radomska, H.S.1    Basseres, D.S.2    Zheng, R.3    Zhang, P.4    Dayaram, T.5    Yamamoto, Y.6
  • 49
    • 33846622099 scopus 로고    scopus 로고
    • Transcription factors in myeloid development: Balancing differentiation with transformation
    • Rosenbauer F, Tenen DG. (2007). Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol 7: 105-117.
    • (2007) Nat Rev Immunol , vol.7 , pp. 105-117
    • Rosenbauer, F.1    Tenen, D.G.2
  • 50
    • 2642519463 scopus 로고    scopus 로고
    • Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    • Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y et al. (2004). Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet 36: 624-630.
    • (2004) Nat Genet , vol.36 , pp. 624-630
    • Rosenbauer, F.1    Wagner, K.2    Kutok, J.L.3    Iwasaki, H.4    Le Beau, M.M.5    Okuno, Y.6
  • 51
    • 12844280533 scopus 로고    scopus 로고
    • Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis
    • Rosmarin AG, Yang Z, Resendes KK. (2005). Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp Hematol 33: 131-143.
    • (2005) Exp Hematol , vol.33 , pp. 131-143
    • Rosmarin, A.G.1    Yang, Z.2    Resendes, K.K.3
  • 53
    • 0037441589 scopus 로고    scopus 로고
    • M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: A report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH)
    • Roumier C, Eclache V, Imbert M, Davi F, MacIntyre E, Garand R et al. (2003). M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH). Blood 101: 1277-1283.
    • (2003) Blood , vol.101 , pp. 1277-1283
    • Roumier, C.1    Eclache, V.2    Imbert, M.3    Davi, F.4    MacIntyre, E.5    Garand, R.6
  • 54
    • 21744438305 scopus 로고    scopus 로고
    • Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukemia
    • Sellick GS, Spendlove HE, Catovsky D, Pritchard-Jones K, Houlston RS. (2005). Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukemia. Leukemia 19: 1276-1278.
    • (2005) Leukemia , vol.19 , pp. 1276-1278
    • Sellick, G.S.1    Spendlove, H.E.2    Catovsky, D.3    Pritchard-Jones, K.4    Houlston, R.S.5
  • 55
    • 33646474281 scopus 로고    scopus 로고
    • AML patients with CEBPA mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: A comparative analysis on paired diagnosis and relapse samples
    • Shih LY, Liang DC, Huang CF, Wu JH, Lin TL, Wang PN et al. (2006). AML patients with CEBPA mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples. Leukemia 20: 604-609.
    • (2006) Leukemia , vol.20 , pp. 604-609
    • Shih, L.Y.1    Liang, D.C.2    Huang, C.F.3    Wu, J.H.4    Lin, T.L.5    Wang, P.N.6
  • 57
    • 33749510883 scopus 로고    scopus 로고
    • LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    • Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K et al. (2006). LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med 12: 1191-1197.
    • (2006) Nat Med , vol.12 , pp. 1191-1197
    • Skokowa, J.1    Cario, G.2    Uenalan, M.3    Schambach, A.4    Germeshausen, M.5    Battmer, K.6
  • 58
    • 13444257421 scopus 로고    scopus 로고
    • Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3
    • Smith ML, Arch R, Smith LL, Bainton N, Neat M, Taylor C et al. (2005). Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. Br J Haematol 128: 318-323.
    • (2005) Br J Haematol , vol.128 , pp. 318-323
    • Smith, M.L.1    Arch, R.2    Smith, L.L.3    Bainton, N.4    Neat, M.5    Taylor, C.6
  • 61
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    • Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D et al. (1999). Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 23: 166-175.
    • (1999) Nat Genet , vol.23 , pp. 166-175
    • Song, W.J.1    Sullivan, M.G.2    Legare, R.D.3    Hutchings, S.4    Tan, X.5    Kufrin, D.6
  • 62
    • 19944418810 scopus 로고    scopus 로고
    • Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukemia
    • Suraweera N, Meijne E, Moody J, Carvajal-Carmona LG, Yoshida L, Pollard P et al. (2005). Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukemia. Oncogene 24: 3678-3683.
    • (2005) Oncogene , vol.24 , pp. 3678-3683
    • Suraweera, N.1    Meijne, E.2    Moody, J.3    Carvajal-Carmona, L.G.4    Yoshida, L.5    Pollard, P.6
  • 63
    • 33644958558 scopus 로고    scopus 로고
    • Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein α activity in lung cancer
    • Tada Y, Brena RM, Hackanson B, Morrison C, Otterson GA, Plass C. (2006). Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein α activity in lung cancer. J Natl Cancer Inst 98: 396-406.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 396-406
    • Tada, Y.1    Brena, R.M.2    Hackanson, B.3    Morrison, C.4    Otterson, G.A.5    Plass, C.6
  • 64
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • Tenen DG. (2003). Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 3: 89-101.
    • (2003) Nat Rev Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 65
    • 0030854907 scopus 로고    scopus 로고
    • Transcription factors, normal myeloid development, and leukemia
    • Tenen DG, Hromas R, Licht JD, Zhang DE. (1997). Transcription factors, normal myeloid development, and leukemia. Blood 90: 489-519.
    • (1997) Blood , vol.90 , pp. 489-519
    • Tenen, D.G.1    Hromas, R.2    Licht, J.D.3    Zhang, D.E.4
  • 66
    • 0036787010 scopus 로고    scopus 로고
    • Calreticulin interacts with C/EBPα and C/EBPβ mRNAs and represses translation of C/EBP proteins
    • Timchenko LT, Iakova P, Welm AL, Cai ZJ, Timchenko NA. (2002). Calreticulin interacts with C/EBPα and C/EBPβ mRNAs and represses translation of C/EBP proteins. Mol Cell Biol 22: 7242-7257.
    • (2002) Mol Cell Biol , vol.22 , pp. 7242-7257
    • Timchenko, L.T.1    Iakova, P.2    Welm, A.L.3    Cai, Z.J.4    Timchenko, N.A.5
  • 67
    • 0037307675 scopus 로고    scopus 로고
    • CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia
    • Truong BTH, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N et al. (2003). CCAAT/enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood 101: 1141-1148.
    • (2003) Blood , vol.101 , pp. 1141-1148
    • Truong, B.T.H.1    Lee, Y.J.2    Lodie, T.A.3    Park, D.J.4    Perrotti, D.5    Watanabe, N.6
  • 68
    • 11144358111 scopus 로고    scopus 로고
    • Valk PJM, Verhaak RGW, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doom Khosrovani S, Boer JM et al. (2004). Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350: 1617-1628.
    • Valk PJM, Verhaak RGW, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doom Khosrovani S, Boer JM et al. (2004). Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350: 1617-1628.
  • 69
    • 0037222293 scopus 로고    scopus 로고
    • The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
    • Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG et al. (2003). The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood 101: 270-277.
    • (2003) Blood , vol.101 , pp. 270-277
    • Vangala, R.K.1    Heiss-Neumann, M.S.2    Rangatia, J.S.3    Singh, S.M.4    Schoch, C.5    Tenen, D.G.6
  • 70
    • 33646589342 scopus 로고    scopus 로고
    • Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy
    • Wagner K, Zhang P, Rosenbauer F, Drescher B, Kobayashi S, Radomska HS et al. (2006). Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy. Proc Natl Acad Sci USA 103: 6338-6343.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6338-6343
    • Wagner, K.1    Zhang, P.2    Rosenbauer, F.3    Drescher, B.4    Kobayashi, S.5    Radomska, H.S.6
  • 71
    • 24644482422 scopus 로고    scopus 로고
    • Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARA
    • Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S et al. (2005). Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARA. Proc Natl Acad Sci USA 102: 12513-12518.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12513-12518
    • Walter, M.J.1    Park, J.S.2    Ries, R.E.3    Lau, S.K.4    McLellan, M.5    Jaeger, S.6
  • 72
    • 33747177840 scopus 로고    scopus 로고
    • C/EBPα directs monocytic commitment of primary myeloid progenitors
    • Wang D, D'Costa J, Civin CI, Friedman AD. (2006). C/EBPα directs monocytic commitment of primary myeloid progenitors. Blood 108: 1223-1229.
    • (2006) Blood , vol.108 , pp. 1223-1229
    • Wang, D.1    D'Costa, J.2    Civin, C.I.3    Friedman, A.D.4
  • 73
    • 1942466512 scopus 로고    scopus 로고
    • Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of CEBPA growth inhibitory activity
    • Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA. (2004). Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of CEBPA growth inhibitory activity. Genes Dev 18: 912-925.
    • (2004) Genes Dev , vol.18 , pp. 912-925
    • Wang, G.L.1    Iakova, P.2    Wilde, M.3    Awad, S.4    Timchenko, N.A.5
  • 74
    • 33846030429 scopus 로고    scopus 로고
    • A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML
    • Wouters BJ, Louwers I, Valk PJM, Löwenberg B, Delwel R. (2007). A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML. Blood 109: 389-390.
    • (2007) Blood , vol.109 , pp. 389-390
    • Wouters, B.J.1    Louwers, I.2    Valk, P.J.M.3    Löwenberg, B.4    Delwel, R.5
  • 75
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H, Ye M, Feng R, Graf T. (2004). Stepwise reprogramming of B cells into macrophages. Cell 117: 663-676.
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Ye, M.2    Feng, R.3    Graf, T.4
  • 76
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. (1997). Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci USA 94: 569-574.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 77
    • 10344230611 scopus 로고    scopus 로고
    • Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα
    • Zhang P, Iwasaki-Arai J, Iwasaki H, Fenyus ML, Dayaram T, Owens BM et al. (2004). Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity 21: 853-863.
    • (2004) Immunity , vol.21 , pp. 853-863
    • Zhang, P.1    Iwasaki-Arai, J.2    Iwasaki, H.3    Fenyus, M.L.4    Dayaram, T.5    Owens, B.M.6
  • 78
    • 1442307974 scopus 로고    scopus 로고
    • Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression
    • Zheng R, Friedman AD, Levis M, Li L, Weir EG, Small D. (2004). Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression. Blood 103: 1883-1890.
    • (2004) Blood , vol.103 , pp. 1883-1890
    • Zheng, R.1    Friedman, A.D.2    Levis, M.3    Li, L.4    Weir, E.G.5    Small, D.6


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