Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis

Experimental Hematology

Volumn 33, Issue 2, 2005, Pages 131-143

  Rosmarin, Alan G ^a,b,c   Yang, Zhongfa ^b   Resendes, Karen K ^b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c MIRIAM HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1;

ARTICLE; BONE MARROW CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL MATURATION; CHROMATIN; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GRANULOCYTE; HEMATOPOIETIC CELL; HUMAN; LEUKEMOGENESIS; MONOCYTE; MUTAGENESIS; MYELOPOIESIS; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; TRANSCRIPTION REGULATION;

EID: 12844280533     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2004.08.015     Document Type: Review

References (160)

1. D. Metcalf, and N.A. Nicola The Hemopoietic Colony-Stimulating Factors: From Biology to Clinical Applicatons 1995 Cambridge University Press Cambridge 12
2. R.A. Shivdasani, and S.H. Orkin The transcriptional control of hematopoiesis Blood 87 1996 4025 4039
3. J. Zhu, and S.G. Emerson Hematopoietic cytokines, transcription factors and lineage commitment Oncogene 21 2002 3295 3313
4. A.D. Friedman Transcriptional regulation of granulocyte and monocyte development Oncogene 21 2002 3377 3390
5. D.G. Skalnik Transcriptional mechanisms regulating myeloid-specific genes Gene 284 2002 1 21
6. D.G. Tenen Disruption of differentiation in human cancer: AML shows the way Nat Rev Cancer 3 2003 89 101
7. E. Fuchs, and J.A. Segre Stem cells: a new lease on life Cell 100 2000 143 155
8. I.L. Weissman Stem cells: units of development, units of regeneration, and units in evolution Cell 100 2000 157 168
9. M. Kondo, I.L. Weissman, and K. Akashi Identification of clonogenic common lymphoid progenitors in mouse bone marrow Cell 91 1997 661 672
10. K. Akashi, D. Traver, T. Miyamoto, and I.L. Weissman A clonogenic common myeloid progenitor that gives rise to all myeloid lineages Nature 404 2000 193 197
11. D. Allman, J.A. Punt, D.J. Izon, J.C. Aster, and W.S. Pear An invitation to T and more: notch signaling in lymphopoiesis Cell 109 2002 S1 S11
12. E.L. Herzog, L. Chai, and D.S. Krause Plasticity of marrow-derived stem cells Blood 102 2003 3483 3493
13. P.J. Quesenberry, M. Abedi, and J. Aliotta Stem cell plasticity: an overview Blood Cells Mol Dis 32 2004 1 4
14. T. Enver, C.M. Heyworth, and T.M. Dexter Do stem cells play dice? Blood 92 1998 348 351
15. D. Metcalf Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation Blood 92 1998 345 347
16. G. Brown, C.M. Bunce, J.M. Lord, and F.M. McConnell The development of cell lineages: a sequential model Differentiation 39 1988 83 89
17. P.J. Quesenberry, G.A. Colvin, and J.F. Lambert The chiaroscuro stem cell: a unified stem cell theory Blood 100 2002 4266 4271
18. M.A. Kirkland A phase space model of hemopoiesis and the concept of stem cell renewal Exp Hematol 32 2004 511 519
19. A.S. Perkins, J.A. Mercer, N.A. Jenkins, and N.G. Copeland Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development Development 111 1991 479 487
20. H.M. Bond, P. Bonelli, and M. Mesuraca Identification by differential display of transcripts regulated during hematopoietic differentiation Stem Cells 16 1998 136 143
21. S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood 96 2000 950 957
22. R.L. Phillips, R.E. Ernst, and B. Brunk The genetic program of hematopoietic stem cells Science 288 2000 1635 1640
23. N.B. Ivanova, J.T. Dimos, C. Schaniel, J.A. Hackney, K.A. Moore, and I.R. Lemischka A stem cell molecular signature Science 298 2002 601 604
24. M. Hu, D. Krause, and M. Greaves Multilineage gene expression precedes commitment in the hemopoietic system Genes Dev 11 1997 774 785
25. F. Billia, M. Barbara, J. McEwen, M. Trevisan, and N.N. Iscove Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts Blood 97 2001 2257 2268
26. T. Miyamoto, H. Iwasaki, and B. Reizis Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment Dev Cell 3 2002 137 147
27. M. Ye, H. Iwasaki, and C.V. Laiosa Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential Immunity 19 2003 689 699
28. S.F. Tsai, E. Strauss, and S.H. Orkin Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter Genes Dev 5 1991 919 931
29. H. Chen, D. Ray-Gallet, and P. Zhang PU.1 (Spi-1) autoregulates its expression in myeloid cells Oncogene 11 1995 1549 1560
30. A.W. Boyd, and J.W. Schrader Derivation of macrophage-like lines from the pre-B lymphoma ABLS 8.1 using 5-azacytidine Nature 297 1982 691 693
31. S.P. Klinken, W.S. Alexander, and J.M. Adams Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages Cell 53 1988 857 867
32. G.V. Borzillo, R.A. Ashmun, and C.J. Sherr Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes Mol Cell Biol 10 1990 2703 2714
33. J. Iwasaki-Arai, H. Iwasaki, T. Miyamoto, S. Watanabe, and K. Akashi Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion J Exp Med 197 2003 1311 1322
34. M. Kondo, D.C. Scherer, and T. Miyamoto Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines Nature 407 2000 383 386
35. A.B. Lassar, B.M. Paterson, and H. Weintraub Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts Cell 47 1986 649 656
36. J. Choi, M.L. Costa, C.S. Mermelstein, C. Chagas, S. Holtzer, and H. Holtzer MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes Proc Natl Acad Sci USA 87 1990 7988 7992
37. I. Mikkola, B. Heavey, M. Horcher, and M. Busslinger Reversion of B cell commitment upon loss of Pax5 expression Science 297 2002 110 113
38. S.L. Nutt, B. Heavey, A.G. Rolink, and M. Busslinger Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 Nature 401 1999 556 562
39. B. Heavey, C. Charalambous, C. Cobaleda, and M. Busslinger Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors EMBO J 22 2003 3887 3897
40. H. Kulessa, J. Frampton, and T. Graf GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts Genes Dev 9 1995 1250 1262
41. C. Nerlov, and T. Graf PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors Genes Dev 12 1998 2403 2412
42. C. Heyworth, S. Pearson, G. May, and T. Enver Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells EMBO J 21 2002 3770 3781
43. H.S. Radomska, C.S. Huettner, P. Zhang, T. Cheng, D.T. Scadden, and D.G. Tenen CCAAT enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors Mol Cell Biol 18 1998 4301 4314
44. H. Xie, M. Ye, R. Feng, and T. Graf Stepwise reprogramming of B cells into macrophages Cell 117 2004 663 676
45. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
46. G.A. Blobel CREB-binding protein and p300: molecular integrators of hematopoietic transcription Blood 95 2002 745 755
47. Y. Yamaguchi, M. Kurokawa, and Y. Imai AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues J Biol Chem 279 2004 15630 15638
48. C. Schwartz, K. Beck, and S. Mink Recruitment of p300 by C/EBPbeta triggers phosphorylation of p300 and modulates coactivator activity EMBO J 22 2003 882 892
49. A. Melnick, and J.D. Licht Histone deacetylases as therapeutic targets in hematologic malignancies Curr Opin Hematol 9 2002 322 332
50. A. Bird DNA methylation patterns and epigenetic memory Genes Dev 16 2002 6 21
51. H. Santos-Rosa, R. Schneider, and A.J. Bannister Active genes are tri-methylated at K4 of histone H3 Nature 419 2002 407 411
52. X. Zhang, Z. Yang, and S.I. Khan Structural basis for the product specificity of histone lysine methyltransferases Mol Cell 12 2003 177 185
53. J. Kontaraki, H.H. Chen, A. Riggs, and C. Bonifer Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression Genes Dev 14 2000 2106 2122
54. P. Lefevre, J. Kontaraki, and C. Bonifer Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element Nucleic Acids Res 29 2001 4551 4560
55. H. Tagoh, S. Melnik, P. Lefevre, S. Chong, A.D. Riggs, and C. Bonifer Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro Blood 103 2004 2950 2955
56. O.M. Sobulo, J. Borrow, and R. Tomek MLL is fused to CBP, a histone acetyltransferase, in therapy- related acute myeloid leukemia with a t(11;16)(q23;p13.3) Proc Natl Acad Sci USA 94 1997 8732 8737
57. L.M. Kelly, and D.G. Gilliland Genetics of myeloid leukemias Annu Rev Genomics Hum Genet 3 2002 179 198
58. M.F. Nunn, P.H. Seeburg, C. Moscovici, and P.H. Duesberg Tripartite structure of the avain erythroblastosis virus E26 transforming gene Nature 306 1983 391 395
59. D. Leprince, A. Gegonne, and J. Coll A putative second cell-derived oncogene of the avian leukaemia retrovirus E26 Nature 306 1983 395 397
60. L.W. Donaldson, J.M. Petersen, B.J. Graves, and L.P. Mclntosh Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif EMBO J 15 1996 125 134
61. M.H. Wemer, G.M. Clore, and C.L. Fisher The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation Cell 83 1995 761 771
62. R. Kodandapani, F. Pio, and C.Z. Ni A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex Nature 380 1996 456 460
63. B. Wasylyk, S.L. Hahn, and A. Giovane The Ets family of transcription factors Eur J Biochem 211 1993 7 18
64. A.D. Sharrocks, A.L. Brown, Y. Ling, and P.R. Yates The ETS-domain transcription factor family Int J Biochem Cell Biol 29 1997 1371 1387
65. T. Oikawa, and T. Yamada Molecular biology of the Ets family of transcription factors Gene 303 2003 11 34
66. Moreau-Gachelin F, Ray D, Mattei MG, Tambourin P, Tavitian A. The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene. 1989;4:1449-1456. Erratum in Oncogene 1990;5:1611-1612.
67. R. Paul, S. Schuetze, S.L. Kozak, C.A. Kozak, and D. Kabat The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the ets-related transcription factor Pu.1 J Virol 65 1991 464 467
68. M.J. Klemsz, S.R. McKercher, A. Celada, C. Van Beveren, and R.A. Maki The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene Cell 61 1990 113 124
69. H.M. Chen, P. Zhang, and M. Voso Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B Blood 85 1995 2918 2928
70. T. Cheng, H.M. Shen, D. Giokas, J. Gere, D.G. Tenen, and D.T. Scadden Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells Proc Natl Acad Sci USA 93 1996 13158 13163
71. R. Hromas, A. Orazi, and R.S. Neiman Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1 Blood 82 1993 2998 3004
72. H.L. Pahl, R.J. Scheibe, and D.E. Zhang The proto-oncogene PU.1 regulates expression of the myeloid- specific CD11b promoter J Biol Chem 268 1998 5014 5020
73. 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity Proc Natl Acad Sci USA 92 1995 801 805
74. M.A. Reddy, B.S. Yang, and X. Yue Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes J Exp Med 180 1994 2309 2319
75. D.E. Zhang, C.J. Hetherington, H.M. Chen, and D.G. Tenen The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor Mol Cell Biol 14 1994 373 381
76. S. Hohaus, M.S. Petrovick, M.T. Voso, Z. Sun, D.E. Zhang, and D.G. Tenen PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene Mol Cell Biol 15 1995 5830 5845
77. L.T. Smith, S. Hohaus, D.A. Gonzalez, S.E. Dziennis, and D.G. Tenen PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells Blood 88 1996 1234 1247
78. E.W. Scott, M.C. Simon, J. Anastasi, and H. Singh Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages Science 265 1994 1573 1577
79. S.R. McKercher, B.E. Torbett, and K.L. Anderson Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities EMBO J 15 1996 5647 5658
80. M.C. Olson, E.W. Scott, and A.A. Hack PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation Immunity 3 1995 703 714
81. G.W. Henkel, S.R. McKercher, H. Yamamoto, K.L. Anderson, R.G. Oshima, and R.A. Maki PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells Blood 88 1996 2917 2926
82. K.L. Anderson, K.A. Smith, F. Pio, B.E. Torbett, and R.A. Maki Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent Blood 92 1998 1576 1585
83. R.P. DeKoter, J.C. Walsh, and H. Singh PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors EMBO J 17 1998 4456 4468
84. G.W. Henkel, S.R. McKercher, P.J. Leenen, and R.A. Maki Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1 Blood 93 1999 2849 2858
85. A. Iwama, P. Zhang, G.J. Darlington, S.R. McKercher, R. Maki, and D.G. Tenen Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBP alpha Nucleic Acids Res 26 1998 3034 3043
86. R.P. DeKoter, and H. Singh Regulation of B lymphocyte and macrophage development by graded expression of PU.1 Science 288 2000 1439 1441
87. Y. Shibata, P.Y. Berclaz, Z.C. Chroneos, M. Yoshida, J.A. Whitsett, and B.C. Trapnell GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1 Immunity 15 2001 557 567
88. M.D. Bjerregaard, J. Jurlander, P. Klausen, N. Borregaard, and J.B. Cowland The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow Blood 101 2003 4322 4332
89. A.D. Panopoulos, D. Bartos, L. Zhang, and S.S. Watowich Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1 J Biol Chem 277 2002 19001 19007
90. K.A. Lord, A. Abdollahi, B. Hoffman-Liebermann, and D.A. Liebermann Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation Mol Cell Biol 13 1993 841 851
91. E. Szabo, L.H. Preis, and M.J. Birrer Constitutive cJun expression induces partial macrophage differentiation in U-937 cells Cell Growth Differ 5 1994 439 446
92. J. Li, I. King, and A.C. Sartorelli Differentiation of WEHI-3B D+ myelomonocytic leukemia cells induced by ectopic expression of the protooncogene c-jun Cell Growth Differ 5 1994 743 751
93. G. Behre, A.J. Whitmarsh, and M.P. Coghlan c-Jun is a JNK-independent coactivator of the PU.1 transcription factor J Biol Chem 274 1999 4939 4946
94. P. Zhang, G. Behre, and J. Pan Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1 Proc Natl Acad Sci USA 96 1999 8705 8710
95. P. Zhang, X. Zhang, and A. Iwama PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding Blood 96 2001 2641 2648
96. N. Rekhtman, F. Radparvar, T. Evans, and Al Skoultchi Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells Genes Dev 13 1999 1398 1411
97. C. Nerlov, E. Querfurth, H. Kulessa, and T. Graf GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription Blood 95 2000 2543 2551
98. T. Yamada, M. Abe, and T. Higashi Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells Blood 97 2001 2300 2307
99. C.F. Eisenbeis, H. Singh, and U. Storb Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator Genes Dev 9 1995 1377 1387
100. Z. Mclvor, S. Hein, and H. Fiegler Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation Exp Hemato 31 2003 39 47
101. W.H. Landschulz, P.F. Johnson, and S.L. McKnight The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite Science 243 1989 1681 1688
102. A.D. Friedman, W.H. Landschulz, and S.L. McKnight CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells Genes Dev 3 1989 1314 1322
103. A.D. Friedman, and S.L. McKnight Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene Genes Dev 4 1990 1416 1426
104. C.F. Calkhoven, C. Muller, and A. Leutz Translational control of C/EBPalpha and C/EBPbeta isoform expression Genes Dev 14 2002 1920 1932
105. P. Descombes, and U. Schibler A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA Cell 67 1991 569 579
106. L.M. Scott, Cl Civin, P. Rorth, and A.D. Friedman A novel temporal expression pattern of three C/EBP family members in differentiating Myelomonocytic Cells Blood 80 1992 1725 1735
107. C. Muller, E. Kowenz-Leutz, S. Grieser-Ade, T. Graf, and A. Leutz NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line EMBO J 14 1995 6127 6135
108. 1 is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus Genomics 35 1996 30 38
109. A.D. Friedman GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D cl3 myeloid cells Cancer Res 56 1996 3250 3256
110. D.E. Zhang, C.J. Hetherington, and S. Meyers CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter Mol Cell Biol 16 1996 1231 1240
111. Z. Pan, C.J. Hetherington, and D.E. Zhang CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development J Biol Chem 274 1999 23242 23248
112. A. Khanna-Gupta, T. Zibello, C. Simkevich, A.G. Rosmarin, and N. Berliner Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation Blood 95 2000 3734 3741
113. W. Wang, X. Wang, A.C. Ward, I.P. Touw, and A.D. Friedman C/EBPalpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes Leukemia 15 2002 779 786
114. N. Faust, C. Bonifer, and A.E. Sippel Differential activity of the -2.7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C/EBP and PU.1 transcription factors DNA Cell Biol 18 1999 631 642
115. A.F. Gombart, S.H. Kwok, K.L. Anderson, Y. Yamaguchi, B.E. Torbett, and H.P. Koeffler Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1 Blood 101 2003 3265 3273
116. W. Verbeek, A.F. Gombart, A.M. Chumakov, C. Muller, A.D. Friedman, and H.P. Koeffler C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters Blood 93 1999 3327 3337
117. X.P. Wang, E. Scott, C.L. Sawyers, and A.D. Friedman C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts Blood 94 1999 560 571
118. C. Nerlov, K.M. McNagny, G. Döderlein, E. Kowenz-Leutz, and T. Graf Distinct C/EBP functions are required for eosinophil lineage commitment and maturation Genes Dev 12 1998 2413 2423
119. H. Nakajima, and J.N. Ihle Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein epsilon Blood 98 2001 897 905
120. D.J. Park, A.M. Chumakov, and P.T. Vuong CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment [see comments] J Clin Invest 103 1999 1399 1408
121. Q.F. Wang, and A.D. Friedman CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor Blood 99 2002 2776 2785
122. A. Khanna-Gupta, T. Zibello, H. Sun, J. Lekstrom-Himes, and N. Berliner C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut) Proc Natl Acad Sci USA 98 2001 8000 8005
123. D.E. Zhang, P. Zhang, N.D. Wang, C.J. Hetherington, G.J. Darlington, and D.G. Tenen Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice Proc Natl Acad Sci USA 94 1997 569 574
124. P. Zhang, A. Iwama, M.W. Datta, G.J. Darlington, D.C. Link, and D.G. Tenen Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is critical for granulopoiesis J Exp Med 188 1998 1173 1184
125. P. Zhang, E. Nelson, and H.S. Radomska Induction of granulocytic differentiation by 2 pathways Blood 99 2002 4406 4412
126. S.J. Collins, J. Ulmer, L.E. Purton, and G. Darlington Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte-colony-stimulating factor, and retinoic acid-induced granulocytic differentiation Blood 98 2001 2382 2388
127. Screpanti I, Romani L, Musiani P, et al. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice. EMBO J. 1995;14:1932-1941. Erratum in EMBO J. 1995;14:3596.
128. T. Tanaka, S. Akira, and K. Yoshida Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages Cell 80 1995 353 361
129. T. Tanaka, N. Yoshida, T. Kishimoto, and S. Akira Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene EMBO J 16 1997 7432 7443
130. R. Yamanaka, C. Barlow, and J. Lekstrom-Himes Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice Proc Natl Acad Sci USA 94 1997 13187 13192
131. J.A. Lekstrom-Himes, S.E. Dorman, P. Kopar, S.M. Holland, and Jl Gallin Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/Enhancer binding protein epsilon J Exp Med 189 1999 1847 1852
132. P. Gaines, and N. Berliner Retinoids in myelopoiesis J Biol Regul Homeost Agents 17 2003 46 65
133. S. Tsai, and S.J. Collins A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage Proc Natl Acad Sci USA 90 1993 7153 7157
134. A. Melnick, and J.D. Licht Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia Blood 93 1999 3167 3215
135. M.E. Huang, Y.C. Ye, and S.R. Chen Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia Blood 72 1988 567 572
136. P. Erickson, J. Gao, and K.S. Chang Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt Blood 80 1992 1825 1831
137. H. Miyoshi, K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1 Proc Natl Acad Sci USA 88 1991 10431 10434
138. P. Liu, S.A. Tarle, and A. Hajra Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia Science 261 1993 1041 1044
139. A. Takahashi, M. Satake, and Y. Yamaguchi-Iwai Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2 Blood 86 1995 607 616
140. P.N. Cockerill, C.S. Osbome, A.G. Bert, and R.J. Grotto Regulation of GM-CSF gene transcription by core-binding factor Cell Growth Differ 7 1996 917 922
141. J. Suzow, and A.D. Friedman The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1) Mol Cell Biol 13 1993 2141 2151
142. I. Nuchprayoon, S. Meyers, L.M. Scott, J. Suzow, S. Hiebert, and A.D. Friedman PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells Mol Cell Biol 14 1994 5558 5568
143. T. Okuda, J. van Deursen, S.W. Hiebert, G. Grosveld, and J.R. Downing AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis Cell 84 1996 321 330
144. Q. Wang, T. Stacy, M. Binder, M. Marin-Padilla, A.H. Sharpe, and N.A. Speck Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis Proc Natl Acad Sci USA 93 1996 3444 3449
145. Q. Wang, T. Stacy, and J.D. Miller The CBFβ subunit is essential for CBFα2 (AML1) function in vivo Cell 87 1996 697 708
146. L.H. Castilla, C. Wijmenga, and Q. Wang Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11 Cell 87 1996 687 696
147. J.J. Westendorf, C.M. Yamamato, N. Lenny, J.R. Downing, M.E. Selsted, and S.W. Hiebert The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation Mol Cell Biol 18 1998 322 333
148. R.K. Vangala, M.S. Heiss-Neumann, and J.S. Rangatia The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia Blood 101 2003 270 277
149. T. Pabst, B.U. Mueller, and P. Zhang Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia Nat Genet 27 2001 263 270
150. A.F. Gombart, W.K. Hofmann, and S. Kawano Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias Blood 99 2002 1332 1340
151. J. Snaddon, M.L. Smith, and M. Neat Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2 Genes Chromosomes Cancer 37 2003 72 78
152. C. Preudhomme, C. Sagot, and N. Boissel Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA) Blood 100 2002 2717 2723
153. B.U. Mueller, T. Pabst, and M. Osato Heterozygous PU.1 mutations are associated with acute myeloid leukemia Blood 100 2002 998 1007
154. F. Rosenbauer, K. Wagner, and J.L. Kutok Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1 Nat Genet 36 2004 624 630
155. D. Brown, S. Kogan, and E. Lagasse A PMLRARalpha transgene initiates murine acute promyelocytic leukemia Proc Natl Acad Sci USA 94 1997 2551 2556
156. J.L. Grisolano, R.L. Wesselschmidt, P.G. Pelicci, and T.J. Ley Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARα under control of cathepsin G regulatory sequences Blood 89 1997 376 387
157. L.Z. He, C. Tribioli, and R. Rivi Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice Proc Natl Acad Sci USA 94 1997 5302 5307
158. G.X. Cheng, X.H. Zhu, and X.Q. Men Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha Proc Natl Acad Sci USA 96 1999 6318 6323
159. L.Z. He, F. Guidez, and C. Tribioli Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL Nat Genet 18 1998 126 135
160. J.R. Downing The core-binding factor leukemias: lessons learned from murine models Curr Opin Genet Dev 13 2003 48 54