-
1
-
-
0034131481
-
Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells
-
Abonour R, Williams DA, Einhorn L, et al. Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nat Med 2000; 6: 652-658.
-
(2000)
Nat Med
, vol.6
, pp. 652-658
-
-
Abonour, R.1
Williams, D.A.2
Einhorn, L.3
-
2
-
-
12144291445
-
Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients
-
Amado RG, Mitsuyasu RT, Rosenblatt JD, et al. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients. Hum Gene Ther 2004; 15: 251-262.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 251-262
-
-
Amado, R.G.1
Mitsuyasu, R.T.2
Rosenblatt, J.D.3
-
3
-
-
20044363101
-
Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma
-
Braybrooke JP, Slade A, Deplanque G, et al. Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma. Clin Cancer Res 2005; 11: 1512-1520.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1512-1520
-
-
Braybrooke, J.P.1
Slade, A.2
Deplanque, G.3
-
4
-
-
0032553681
-
Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: In vivo detection of transduced cells without myeloablation
-
Dunbar CE, Kohn DB, Schiffmann R, et al. Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation. Hum Gene Ther 1998; 9: 2629-2640.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2629-2640
-
-
Dunbar, C.E.1
Kohn, D.B.2
Schiffmann, R.3
-
5
-
-
0031972859
-
Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation
-
Hesdorffer C, Ayello J, Ward M, et al. Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation. J Clin Oncol 1998; 16: 165-172.
-
(1998)
J Clin Oncol
, vol.16
, pp. 165-172
-
-
Hesdorffer, C.1
Ayello, J.2
Ward, M.3
-
6
-
-
0035831628
-
Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase I study
-
Kang WK, Park C, Yoon HL, et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study. Hum Gene Ther 2001; 12: 671-684.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 671-684
-
-
Kang, W.K.1
Park, C.2
Yoon, H.L.3
-
7
-
-
2442721450
-
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma
-
Klatzmann D, Cherin P, Bensimon G, et al. A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma. Hum Gene Ther 1998; 9: 2585-2594.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2585-2594
-
-
Klatzmann, D.1
Cherin, P.2
Bensimon, G.3
-
8
-
-
2442767029
-
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma
-
Klatzmann D, Valery CA, Bensimon G, et al. A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum Gene Ther 1998; 9: 2595-2604.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2595-2604
-
-
Klatzmann, D.1
Valery, C.A.2
Bensimon, G.3
-
9
-
-
0033168686
-
A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children
-
Kohn DB, Bauer G, Rice CR, et al. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood 1999; 94: 368-371.
-
(1999)
Blood
, vol.94
, pp. 368-371
-
-
Kohn, D.B.1
Bauer, G.2
Rice, C.R.3
-
10
-
-
12644293807
-
Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease
-
Malech HL, Maples PB, Whiting-Theobald N, et al. Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease. Proc Natl Acad Sci U S A 1997; 94: 12133-12138.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 12133-12138
-
-
Malech, H.L.1
Maples, P.B.2
Whiting-Theobald, N.3
-
11
-
-
0028819357
-
Clinical application of retroviral gene transfer in oncology: Results of a French study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin
-
Merrouche Y, Negrier S, Bain C, et al. Clinical application of retroviral gene transfer in oncology: results of a French study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin. J Clin Oncol 1995; 13: 410-418.
-
(1995)
J Clin Oncol
, vol.13
, pp. 410-418
-
-
Merrouche, Y.1
Negrier, S.2
Bain, C.3
-
12
-
-
0034254611
-
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects
-
Mitsuyasu RT, Anton PA, Deeks SG, et al. Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood 2000; 96: 785-793.
-
(2000)
Blood
, vol.96
, pp. 785-793
-
-
Mitsuyasu, R.T.1
Anton, P.A.2
Deeks, S.G.3
-
13
-
-
0033587072
-
Phase I trial of interferon gamma retroviral vector administered intratumorally with multiple courses in patients with metastatic melanoma
-
Nemunaitis J, Fong T, Burrows F, et al. Phase I trial of interferon gamma retroviral vector administered intratumorally with multiple courses in patients with metastatic melanoma. Hum Gene Ther 1999; 10: 1289-1298.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 1289-1298
-
-
Nemunaitis, J.1
Fong, T.2
Burrows, F.3
-
14
-
-
0033957146
-
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration
-
Packer RJ, Raffel C, Villablanca JG, et al. Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration. J Neurosurg 2000; 92: 249-254.
-
(2000)
J Neurosurg
, vol.92
, pp. 249-254
-
-
Packer, R.J.1
Raffel, C.2
Villablanca, J.G.3
-
15
-
-
0141679053
-
Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion
-
Powell JS, Ragni MV, White GC II, et al. Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion. Blood 2003; 102: 2038-2045.
-
(2003)
Blood
, vol.102
, pp. 2038-2045
-
-
Powell, J.S.1
Ragni, M.V.2
White II, G.C.3
-
16
-
-
10744233353
-
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: A phase I/II multi-institutional trial
-
Prados MD, McDermott M, Chang SM, et al. Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial. J Neurooncol 2003; 65: 269-278.
-
(2003)
J Neurooncol
, vol.65
, pp. 269-278
-
-
Prados, M.D.1
McDermott, M.2
Chang, S.M.3
-
17
-
-
0034694011
-
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
-
Rainov NG. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 2000; 11: 2389-2401.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2389-2401
-
-
Rainov, N.G.1
-
18
-
-
0031463632
-
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
-
Ram Z, Culver KW, Oshiro EM, et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 1997; 3: 1354-1361.
-
(1997)
Nat Med
, vol.3
, pp. 1354-1361
-
-
Ram, Z.1
Culver, K.W.2
Oshiro, E.M.3
-
19
-
-
9544244796
-
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
-
Roth JA, Nguyen D, Lawrence DD, et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996; 2: 985-991.
-
(1996)
Nat Med
, vol.2
, pp. 985-991
-
-
Roth, J.A.1
Nguyen, D.2
Lawrence, D.D.3
-
20
-
-
0034329438
-
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
-
Sandmair AM, Loimas S, Puranen P, et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum Gene Ther 2000; 11: 2197-2205.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2197-2205
-
-
Sandmair, A.M.1
Loimas, S.2
Puranen, P.3
-
21
-
-
0033588816
-
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group
-
Shand N, Weber F, Mariani L, et al. A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group. Hum Gene Ther 1999; 10: 2325-2335.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2325-2335
-
-
Shand, N.1
Weber, F.2
Mariani, L.3
-
22
-
-
0030944023
-
Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer
-
Simons JW, Jaffee EM, Weber CE, et al. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res 1997; 57: 1537-1546.
-
(1997)
Cancer Res
, vol.57
, pp. 1537-1546
-
-
Simons, J.W.1
Jaffee, E.M.2
Weber, C.E.3
-
23
-
-
0034882131
-
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer
-
Singh S, Cunningham C, Buchanan A, et al. Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer. Mol Ther 2001; 4: 157-160.
-
(2001)
Mol Ther
, vol.4
, pp. 157-160
-
-
Singh, S.1
Cunningham, C.2
Buchanan, A.3
-
24
-
-
0032851163
-
Interleukin 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: A Phase I study
-
Sobol RE, Shawler DL, Carson C, et al. Interleukin 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: a Phase I study. Clin Cancer Res 1999; 5: 2359-2365.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2359-2365
-
-
Sobol, R.E.1
Shawler, D.L.2
Carson, C.3
-
25
-
-
0030656171
-
A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer
-
Tait DL, Obermiller PS, Redlin-Frazier S, et al. A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer. Clin Cancer Res 1997; 3: 1959-1968.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1959-1968
-
-
Tait, D.L.1
Obermiller, P.S.2
Redlin-Frazier, S.3
-
26
-
-
0032790963
-
Ovarian cancer BRCA1 gene therapy: Phase I and II trial differences in immune response and vector stability
-
Tait DL, Obermiller PS, Hatmaker AR, et al. Ovarian cancer BRCA1 gene therapy: Phase I and II trial differences in immune response and vector stability. Clin Cancer Res 1999; 5: 1708-1714.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1708-1714
-
-
Tait, D.L.1
Obermiller, P.S.2
Hatmaker, A.R.3
-
27
-
-
30644457691
-
Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: Biological and clinical results
-
Colombo F, Barzon L, Franchin E, et al. Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results. Cancer Gene Ther 2005; 12: 835-848.
-
(2005)
Cancer Gene Ther
, vol.12
, pp. 835-848
-
-
Colombo, F.1
Barzon, L.2
Franchin, E.3
-
28
-
-
16944367323
-
Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: A phase I clinical trial
-
Bellon G, Michel-Calemard L, Thouvenot D, et al. Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: a phase I clinical trial. Hum Gene Ther 1997; 8: 15-25.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 15-25
-
-
Bellon, G.1
Michel-Calemard, L.2
Thouvenot, D.3
-
29
-
-
0036019371
-
A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer
-
Buller RE, Runnebaum IB, Karlan BY, et al. A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer. Cancer Gene Ther 2002; 9: 553-566.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 553-566
-
-
Buller, R.E.1
Runnebaum, I.B.2
Karlan, B.Y.3
-
30
-
-
0031750168
-
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
-
Clayman GL, el-Naggar AK, Lippman SM, et al. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 1998; 16: 2221-2232.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2221-2232
-
-
Clayman, G.L.1
el-Naggar, A.K.2
Lippman, S.M.3
-
31
-
-
0028168641
-
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
-
Crystal RG, McElvaney NG, Rosenfeld MA, et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 1994; 8: 42-51.
-
(1994)
Nat Genet
, vol.8
, pp. 42-51
-
-
Crystal, R.G.1
McElvaney, N.G.2
Rosenfeld, M.A.3
-
32
-
-
0033914837
-
Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumors
-
Dummer R, Bergh J, Karlsson Y, et al. Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumors. Cancer Gene Ther 2000; 7: 1069-1076.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 1069-1076
-
-
Dummer, R.1
Bergh, J.2
Karlsson, Y.3
-
33
-
-
4444349308
-
Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas
-
Dummer R, Hassel JC, Fellenberg F, et al. Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas. Blood 2004; 104: 1631-1638.
-
(2004)
Blood
, vol.104
, pp. 1631-1638
-
-
Dummer, R.1
Hassel, J.C.2
Fellenberg, F.3
-
34
-
-
0346243603
-
Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: Preliminary results of a phase I trial in patients with recurrent malignant gliomas
-
Germano IM, Fable J, Gultekin SH, et al. Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas. J Neurooncol 2003; 65: 279-289.
-
(2003)
J Neurooncol
, vol.65
, pp. 279-289
-
-
Germano, I.M.1
Fable, J.2
Gultekin, S.H.3
-
35
-
-
0031755084
-
Gene therapy with AdV-IL2 (TG 1021) in unresectable digestive adenocarcinoma. Phase I-II study, first inclusions
-
Gilly FN, Sayag-Beaujard AC, Bienvenu J, et al. Gene therapy with AdV-IL2 (TG 1021) in unresectable digestive adenocarcinoma. Phase I-II study, first inclusions. Adv Exp Med Biol 1998; 451: 527-530.
-
(1998)
Adv Exp Med Biol
, vol.451
, pp. 527-530
-
-
Gilly, F.N.1
Sayag-Beaujard, A.C.2
Bienvenu, J.3
-
36
-
-
0033049082
-
Gene therapy with Adv-IL-2 in unresectable digestive cancer: Phase I-II study, intermediate report
-
Gilly FN, Beaujard A, Bienvenu J, et al. Gene therapy with Adv-IL-2 in unresectable digestive cancer: phase I-II study, intermediate report. Hepatogastroenterology 1999; 46(Suppl 1): 1268-1273.
-
(1999)
Hepatogastroenterology
, vol.46
, Issue.SUPPL. 1
, pp. 1268-1273
-
-
Gilly, F.N.1
Beaujard, A.2
Bienvenu, J.3
-
37
-
-
0037133624
-
Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris
-
Grines CL, Watkins MW, Helmer G, et al. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation 2002; 105: 1291-1297.
-
(2002)
Circulation
, vol.105
, pp. 1291-1297
-
-
Grines, C.L.1
Watkins, M.W.2
Helmer, G.3
-
38
-
-
0037344533
-
Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients
-
Griscelli F, Opolon P, Saulnier P, et al. Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients. Gene Ther 2003; 10: 386-395.
-
(2003)
Gene Ther
, vol.10
, pp. 386-395
-
-
Griscelli, F.1
Opolon, P.2
Saulnier, P.3
-
39
-
-
0032718592
-
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus
-
Harvey BG, Leopold PL, Hackett NR, et al. Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. J Clin Invest 1999; 104: 1245-1255.
-
(1999)
J Clin Invest
, vol.104
, pp. 1245-1255
-
-
Harvey, B.G.1
Leopold, P.L.2
Hackett, N.R.3
-
40
-
-
0033589743
-
Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector
-
Harvey BG, Worgall S, Ely S, et al. Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector. Hum Gene Ther 1999; 10: 2823-2837.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2823-2837
-
-
Harvey, B.G.1
Worgall, S.2
Ely, S.3
-
41
-
-
0033933045
-
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer
-
Hasenburg A, Tong XW, Rojas-Martinez A, et al. Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer. Cancer Gene Ther 2000; 7: 839-844.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 839-844
-
-
Hasenburg, A.1
Tong, X.W.2
Rojas-Martinez, A.3
-
42
-
-
0038210219
-
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: Phase II results of the Kuopio Angiogenesis Trial (KAT)
-
Hedman M, Hartikainen J, Syvanne M, et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). Circulation 2003; 107: 2677-2683.
-
(2003)
Circulation
, vol.107
, pp. 2677-2683
-
-
Hedman, M.1
Hartikainen, J.2
Syvanne, M.3
-
43
-
-
0033135221
-
In situ gene therapy for adenocarcinoma of the prostate: A phase I clinical trial
-
Herman JR, Adler HL, Aguilar-Cordova E, et al. In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial. Hum Gene Ther 1999; 10: 1239-1249.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 1239-1249
-
-
Herman, J.R.1
Adler, H.L.2
Aguilar-Cordova, E.3
-
44
-
-
7044235842
-
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study
-
Immonen A, Vapalahti M, Tyynela K, et al. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol Ther 2004; 10: 967-972.
-
(2004)
Mol Ther
, vol.10
, pp. 967-972
-
-
Immonen, A.1
Vapalahti, M.2
Tyynela, K.3
-
45
-
-
0034820241
-
Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications
-
Joseph PM, O'Sullivan BP, Lapey A, et al. Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications. Hum Gene Ther 2001; 12: 1369-1382.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1369-1382
-
-
Joseph, P.M.1
O'Sullivan, B.P.2
Lapey, A.3
-
46
-
-
0037385454
-
A phase I trial of immunotherapy with intratumoral adenovirus-interferon-gamma (TG1041) in patients with malignant melanoma
-
Khorana AA, Rosenblatt JD, Sahasrabudhe DM, et al. A phase I trial of immunotherapy with intratumoral adenovirus-interferon-gamma (TG1041) in patients with malignant melanoma. Cancer Gene Ther 2003; 10: 251-259.
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 251-259
-
-
Khorana, A.A.1
Rosenblatt, J.D.2
Sahasrabudhe, D.M.3
-
47
-
-
0029100239
-
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
-
Knowles MR, Hohneker KW, Zhou Z, et al. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 1995; 333: 823-831.
-
(1995)
N Engl J Med
, vol.333
, pp. 823-831
-
-
Knowles, M.R.1
Hohneker, K.W.2
Zhou, Z.3
-
48
-
-
0037429003
-
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer
-
Kubo H, Gardner TA, Wada Y, et al. Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer. Hum Gene Ther 2003; 14: 227-241.
-
(2003)
Hum Gene Ther
, vol.14
, pp. 227-241
-
-
Kubo, H.1
Gardner, T.A.2
Wada, Y.3
-
49
-
-
0037083558
-
Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation
-
Kuball J, Wen SF, Leissner J, et al. Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation. J Clin Oncol 2002; 20: 957-965.
-
(2002)
J Clin Oncol
, vol.20
, pp. 957-965
-
-
Kuball, J.1
Wen, S.F.2
Leissner, J.3
-
50
-
-
85047697641
-
Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results
-
Lang FF, Bruner JM, Fuller GN, et al. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J Clin Oncol 2003; 21: 2508-2518.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2508-2518
-
-
Lang, F.F.1
Bruner, J.M.2
Fuller, G.N.3
-
51
-
-
0036665610
-
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
-
Makinen K, Manninen H, Hedman M, et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study. Mol Ther 2002; 6: 127-133.
-
(2002)
Mol Ther
, vol.6
, pp. 127-133
-
-
Makinen, K.1
Manninen, H.2
Hedman, M.3
-
52
-
-
4444295881
-
A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities
-
Mundt AJ, Vijayakumar S, Nemunaitis J, et al. A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities. Clin Cancer Res 2004; 10: 5747-5753.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5747-5753
-
-
Mundt, A.J.1
Vijayakumar, S.2
Nemunaitis, J.3
-
53
-
-
0033950285
-
Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer
-
Nemunaitis J, Swisher SG, Timmons T, et al. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 2000; 18: 609-622.
-
(2000)
J Clin Oncol
, vol.18
, pp. 609-622
-
-
Nemunaitis, J.1
Swisher, S.G.2
Timmons, T.3
-
54
-
-
2442696806
-
Virus-directed enzyme prodrug therapy: Intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer
-
Palmer DH, Mautner V, Mirza D, et al. Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer. J Clin Oncol 2004; 22: 1546-1552.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1546-1552
-
-
Palmer, D.H.1
Mautner, V.2
Mirza, D.3
-
55
-
-
0034831612
-
Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium
-
Perricone MA, Morris JE, Pavelka K, et al. Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium. Hum Gene Ther 2001; 12: 1383-1394.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1383-1394
-
-
Perricone, M.A.1
Morris, J.E.2
Pavelka, K.3
-
56
-
-
0142023866
-
Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: A phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication
-
Rajagopalan S, Mohler ER III, Lederman RJ, et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 2003; 108: 1933-1938.
-
(2003)
Circulation
, vol.108
, pp. 1933-1938
-
-
Rajagopalan, S.1
Mohler III, E.R.2
Lederman, R.J.3
-
57
-
-
0033520056
-
Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
-
Rosengart TK, Lee LY, Patel SR, et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 1999; 100: 468-474.
-
(1999)
Circulation
, vol.100
, pp. 468-474
-
-
Rosengart, T.K.1
Lee, L.Y.2
Patel, S.R.3
-
58
-
-
17344365479
-
A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer
-
Schuler M, Rochlitz C, Horowitz JA, et al. A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer. Hum Gene Ther 1998; 9: 2075-2082.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2075-2082
-
-
Schuler, M.1
Rochlitz, C.2
Horowitz, J.A.3
-
59
-
-
0035868848
-
Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study
-
Schuler M, Herrmann R, De Greve JL, et al. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study. J Clin Oncol 2001; 19: 1750-1758.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1750-1758
-
-
Schuler, M.1
Herrmann, R.2
De Greve, J.L.3
-
60
-
-
1442332187
-
TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: A phase I study in patients with solid tumors
-
Senzer N, Mani S, Rosemurgy A, et al. TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. J Clin Oncol 2004; 22: 592-601.
-
(2004)
J Clin Oncol
, vol.22
, pp. 592-601
-
-
Senzer, N.1
Mani, S.2
Rosemurgy, A.3
-
61
-
-
0037812853
-
Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir
-
Smitt PS, Driesse M, Wolbers J, et al. Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir. Mol Ther 2003; 7: 851-858.
-
(2003)
Mol Ther
, vol.7
, pp. 851-858
-
-
Smitt, P.S.1
Driesse, M.2
Wolbers, J.3
-
62
-
-
17344365922
-
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a phase I clinical trial in malignant mesothelioma
-
Sterman DH, Treat J, Litzky LA, et al. Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther 1998; 9: 1083-1092.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 1083-1092
-
-
Sterman, D.H.1
Treat, J.2
Litzky, L.A.3
-
63
-
-
0034493519
-
A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma
-
Sterman DH, Molnar-Kimber K, Iyengar T, et al. A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma. Cancer Gene Ther 2000; 7: 1511-1518.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 1511-1518
-
-
Sterman, D.H.1
Molnar-Kimber, K.2
Iyengar, T.3
-
64
-
-
0032971662
-
Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: Results of a phase 1 clinical trial
-
Stewart AK, Lassam NJ, Quirt IC, et al. Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial. Gene Ther 1999; 6: 350-363.
-
(1999)
Gene Ther
, vol.6
, pp. 350-363
-
-
Stewart, A.K.1
Lassam, N.J.2
Quirt, I.C.3
-
65
-
-
12444263893
-
A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer
-
Trudel S, Trachtenberg J, Toi A, et al. A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer. Cancer Gene Ther 2003; 10: 755-763.
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 755-763
-
-
Trudel, S.1
Trachtenberg, J.2
Toi, A.3
-
66
-
-
19944384118
-
Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients
-
Tong AW, Nemunaitis J, Su D, et al. Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Mol Ther 2005; 11: 160-172.
-
(2005)
Mol Ther
, vol.11
, pp. 160-172
-
-
Tong, A.W.1
Nemunaitis, J.2
Su, D.3
-
67
-
-
0034136802
-
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors
-
Trask TW, Trask RP, Aguilar-Cordova E, et al. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther 2000; 1: 195-203.
-
(2000)
Mol Ther
, vol.1
, pp. 195-203
-
-
Trask, T.W.1
Trask, R.P.2
Aguilar-Cordova, E.3
-
68
-
-
12644271889
-
Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients
-
Tursz T, Cesne AL, Baldeyrou P, et al. Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients. J Natl Cancer Inst 1996; 88: 1857-1863.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1857-1863
-
-
Tursz, T.1
Cesne, A.L.2
Baldeyrou, P.3
-
69
-
-
3543071097
-
A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer
-
Wolf JK, Bodurka DC, Gano JB, et al. A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer. Gynecol Oncol 2004; 94: 442-448.
-
(2004)
Gynecol Oncol
, vol.94
, pp. 442-448
-
-
Wolf, J.K.1
Bodurka, D.C.2
Gano, J.B.3
-
70
-
-
13344286312
-
Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis
-
Zabner J, Ramsey BW, Meeker DP, et al. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J Clin Invest 1996; 97: 1504-1511.
-
(1996)
J Clin Invest
, vol.97
, pp. 1504-1511
-
-
Zabner, J.1
Ramsey, B.W.2
Meeker, D.P.3
-
71
-
-
0033544951
-
A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis
-
Zuckerman JB, Robinson CB, McCoy KS, et al. A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis. Hum Gene Ther 1999; 10: 2973-2985.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2973-2985
-
-
Zuckerman, J.B.1
Robinson, C.B.2
McCoy, K.S.3
-
72
-
-
32944481724
-
Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a phase I clinical trial
-
Campochiaro PA, Nguyen QD, Shah SM, et al. Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum Gene Ther 2006; 17: 167-176.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 167-176
-
-
Campochiaro, P.A.1
Nguyen, Q.D.2
Shah, S.M.3
-
73
-
-
31644447744
-
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir
-
Chevez-Barrios P, Chintagumpala M, Mieler W, et al. Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol 2005; 23: 7927-7935.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7927-7935
-
-
Chevez-Barrios, P.1
Chintagumpala, M.2
Mieler, W.3
-
74
-
-
33645829571
-
Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer
-
Fujiwara T, Tanaka N, Kanazawa S, et al. Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer. J Clin Oncol 2006; 24: 1689-1699.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1689-1699
-
-
Fujiwara, T.1
Tanaka, N.2
Kanazawa, S.3
-
75
-
-
26644444774
-
Arteriogenic gene therapy in patients with unreconstructable critical limb ischemia: A randomized, placebo-controlled clinical trial of adenovirus 5-delivered fibroblast growth factor-4
-
Matyas L, Schulte KL, Dormandy JA, et al. Arteriogenic gene therapy in patients with unreconstructable critical limb ischemia: a randomized, placebo-controlled clinical trial of adenovirus 5-delivered fibroblast growth factor-4. Hum Gene Ther 2005; 16: 1202-1211.
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1202-1211
-
-
Matyas, L.1
Schulte, K.L.2
Dormandy, J.A.3
-
76
-
-
33646457691
-
Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer
-
Tolcher AW, Hao D, de Bono J, et al. Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer. J Clin Oncol 2006; 24: 2052-2058.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2052-2058
-
-
Tolcher, A.W.1
Hao, D.2
de Bono, J.3
-
77
-
-
0035887153
-
A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
-
DeWeese TL, van der Poel H, Li S, et al. A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Res 2001; 61: 7464-7472.
-
(2001)
Cancer Res
, vol.61
, pp. 7464-7472
-
-
DeWeese, T.L.1
van der Poel, H.2
Li, S.3
-
78
-
-
0036733759
-
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
-
Freytag SO, Khil M, Stricker H, et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res 2002; 62: 4968-4976.
-
(2002)
Cancer Res
, vol.62
, pp. 4968-4976
-
-
Freytag, S.O.1
Khil, M.2
Stricker, H.3
-
79
-
-
10744227813
-
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
-
Freytag SO, Stricker H, Pegg J, et al. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res 2003; 63: 7497-7506.
-
(2003)
Cancer Res
, vol.63
, pp. 7497-7506
-
-
Freytag, S.O.1
Stricker, H.2
Pegg, J.3
-
80
-
-
20144368516
-
Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas
-
Galanis E, Okuno SH, Nascimento AG, et al. Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas. Gene Ther 2005; 12: 437-445.
-
(2005)
Gene Ther
, vol.12
, pp. 437-445
-
-
Galanis, E.1
Okuno, S.H.2
Nascimento, A.G.3
-
81
-
-
12944328660
-
A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
-
Ganly I, Kirn D, Eckhardt G, et al. A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin Cancer Res 2000; 6: 798-806.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 798-806
-
-
Ganly, I.1
Kirn, D.2
Eckhardt, G.3
-
82
-
-
85047699490
-
-
Habib N, Salama H, Abd El Latif Abu Median A, et al. Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma. Cancer Gene Ther 2002; 9: 254-259.
-
Habib N, Salama H, Abd El Latif Abu Median A, et al. Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma. Cancer Gene Ther 2002; 9: 254-259.
-
-
-
-
83
-
-
10244253939
-
Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: A pilot phase II clinical trial
-
Lu W, Zheng S, Li XF, et al. Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: a pilot phase II clinical trial. World J Gastroenterol 2004; 10: 3634-3638.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 3634-3638
-
-
Lu, W.1
Zheng, S.2
Li, X.F.3
-
84
-
-
0037314655
-
Phase II clinical trial of intralesional administration of the oncolytic adenovirus ONYX-015 in patients with hepatobiliary tumors with correlative p53 studies
-
Makower D, Rozenblit A, Kaufman H, et al. Phase II clinical trial of intralesional administration of the oncolytic adenovirus ONYX-015 in patients with hepatobiliary tumors with correlative p53 studies. Clin Cancer Res 2003; 9: 693-702.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 693-702
-
-
Makower, D.1
Rozenblit, A.2
Kaufman, H.3
-
85
-
-
0035076823
-
Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
-
Mulvihill S, Warren R, Venook A, et al. Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther 2001; 8: 308-315.
-
(2001)
Gene Ther
, vol.8
, pp. 308-315
-
-
Mulvihill, S.1
Warren, R.2
Venook, A.3
-
86
-
-
0035863458
-
Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
-
Nemunaitis J, Khuri F, Ganly I, et al. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J Clin Oncol 2001; 19: 289-298.
-
(2001)
J Clin Oncol
, vol.19
, pp. 289-298
-
-
Nemunaitis, J.1
Khuri, F.2
Ganly, I.3
-
87
-
-
0037087621
-
Phase I trial of intraperitoneal injection of the E1B-55-kd-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer
-
Vasey PA, Shulman LN, Campos S, et al. Phase I trial of intraperitoneal injection of the E1B-55-kd-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer. J Clin Oncol 2002; 20: 1562-1569.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1562-1569
-
-
Vasey, P.A.1
Shulman, L.N.2
Campos, S.3
-
88
-
-
0034779927
-
A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease
-
Aitken ML, Moss RB, Waltz DA, et al. A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease. Hum Gene Ther 2001; 12: 1907-1916.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1907-1916
-
-
Aitken, M.L.1
Moss, R.B.2
Waltz, D.A.3
-
89
-
-
0038488551
-
Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: A two-part clinical study
-
Flotte TR, Zeitlin PL, Reynolds TC, et al. Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. Hum Gene Ther 2003; 14: 1079-1088.
-
(2003)
Hum Gene Ther
, vol.14
, pp. 1079-1088
-
-
Flotte, T.R.1
Zeitlin, P.L.2
Reynolds, T.C.3
-
90
-
-
0034050904
-
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
-
Kay MA, Manno CS, Ragni MV, et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet 2000; 24: 257-261.
-
(2000)
Nat Genet
, vol.24
, pp. 257-261
-
-
Kay, M.A.1
Manno, C.S.2
Ragni, M.V.3
-
91
-
-
33644820684
-
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
-
Manno CS, Pierce GF, Arruda VR, et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med 2006; 12: 342-347.
-
(2006)
Nat Med
, vol.12
, pp. 342-347
-
-
Manno, C.S.1
Pierce, G.F.2
Arruda, V.R.3
-
92
-
-
10744227749
-
Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial
-
Moss RB, Rodman D, Spencer LT, et al. Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial. Chest 2004; 125: 509-521.
-
(2004)
Chest
, vol.125
, pp. 509-521
-
-
Moss, R.B.1
Rodman, D.2
Spencer, L.T.3
-
93
-
-
0033022349
-
Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus
-
Wagner JA, Messner AH, Moran ML, et al. Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. Laryngoscope 1999; 109: 266-274.
-
(1999)
Laryngoscope
, vol.109
, pp. 266-274
-
-
Wagner, J.A.1
Messner, A.H.2
Moran, M.L.3
-
94
-
-
0036377851
-
A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies
-
Wagner JA, Nepomuceno IB, Messner AH, et al. A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum Gene Ther 2002; 13: 1349-1359.
-
(2002)
Hum Gene Ther
, vol.13
, pp. 1349-1359
-
-
Wagner, J.A.1
Nepomuceno, I.B.2
Messner, A.H.3
-
95
-
-
10744220391
-
Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia
-
Baldwin PJ, van der Burg SH, Boswell CM, et al. Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia. Clin Cancer Res 2003; 9: 5205-5213.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5205-5213
-
-
Baldwin, P.J.1
van der Burg, S.H.2
Boswell, C.M.3
-
96
-
-
15844365301
-
A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
-
Borysiewicz LK, Fiander A, Nimako M, et al. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet 1996; 347: 1523-1527.
-
(1996)
Lancet
, vol.347
, pp. 1523-1527
-
-
Borysiewicz, L.K.1
Fiander, A.2
Nimako, M.3
-
97
-
-
0034106260
-
Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: Persistent transgene expression despite antibody generation
-
Mukherjee S, Haenel T, Himbeck R, et al. Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation. Cancer Gene Ther 2000; 7: 663-670.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 663-670
-
-
Mukherjee, S.1
Haenel, T.2
Himbeck, R.3
-
98
-
-
0742324611
-
Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer
-
Rochlitz C, Figlin R, Squiban P, et al. Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer. J Gene Med 2003; 5: 690-699.
-
(2003)
J Gene Med
, vol.5
, pp. 690-699
-
-
Rochlitz, C.1
Figlin, R.2
Squiban, P.3
-
99
-
-
0033852076
-
Recombinant vaccinia virus oncoding human MUC1 and IL2 as immunotherapy in patients with breast cancer
-
Scholl SM, Balloul JM, Le Goc G, et al. Recombinant vaccinia virus oncoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J Immunother 2000; 23: 570-580.
-
(2000)
J Immunother
, vol.23
, pp. 570-580
-
-
Scholl, S.M.1
Balloul, J.M.2
Le Goc, G.3
-
101
-
-
0013902464
-
Aerosol-induced adenoviral illness resembling the naturally occurring illness in military recruits
-
Couch RB, Cate TR, Fleet WF, et al. Aerosol-induced adenoviral illness resembling the naturally occurring illness in military recruits. Am Rev Respir Dis 1966; 93: 529-535.
-
(1966)
Am Rev Respir Dis
, vol.93
, pp. 529-535
-
-
Couch, R.B.1
Cate, T.R.2
Fleet, W.F.3
|