Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumors

Cancer Gene Therapy

Volumn 7, Issue 7, 2000, Pages 1069-1076

  Dummer, Reinhard ^a   Bergh, Jonas ^b   Karlsson, Ylva ^b   Horowitz, Jo Ann ^c   Mulder, Nanno H ^d   Huinink, Daan Ten Bokkel ^e   Burg, Günter ^a   Hofbauer, Günther ^a   Osanto, Susanne ^e  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adenoviral vector; Breast cancer; Gene therapy; Melanoma; P53; Phase I trial

Indexed keywords

PROTEIN P53; VIRUS ANTIBODY;

ADENOVIRUS; ADULT; AGED; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CLINICAL TRIAL; EDEMA; EXPRESSION VECTOR; FATIGUE; FEMALE; FEVER; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE THERAPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MELANOMA; MULTICENTER STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TACHYCARDIA;

ADENOVIRIDAE;

EID: 0033914837     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700214     Document Type: Article

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