c-Jun N-terminal kinase 1 is required for toll-like receptor 1 gene expression in macrophages

Infection and Immunity

Volumn 75, Issue 10, 2007, Pages 5027-5034

  Izadi, Hooman ^a   Motameni, Amirreza T ^b   Bates, Tonya C ^a,b   Olivera, Elias R ^a   Villar Suarez, Vega ^a   Joshi, Ila ^a   Garg, Renu ^b   Osborne, Barbara A ^a   Davis, Roger J ^c   Rincón, Mercedes ^d   Anguita, Juan ^a,b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CD11B ANTIGEN; HETERODIMER; IMMUNOMODULATING AGENT; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE P38; N PALMITOYL [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINYLSERYLTETRALYSINE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUND; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL GENE; BINDING SITE; BORRELIA BURGDORFERI; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE EXPRESSION; HOST PATHOGEN INTERACTION; IMMUNOREGULATION; INNATE IMMUNITY; LYME DISEASE; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPIROCHETE; TLR1 GENE;

ANIMALS; BASE SEQUENCE; BINDING SITES; BORRELIA BURGDORFERI; CELL LINE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 8; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); TOLL-LIKE RECEPTOR 1;

EID: 34848846144     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00492-07     Document Type: Article

References (41)

1. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124:783-801.
2. Alexopoulo, L., T. Thomas, M. Schnare, Y. Lobet, J. Anguita, R. T. Schoen, R. Medzhitov, E. Fikrig, and R. A. Flavell. 2002. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat. Med. 8:878-884.
3. Anguita, J., S. W. Barthold, R. Persinski, M. N. Hedrick, C. A. Huy, R. J. Davis, R. A. Flavell, and E. Fikrig. 2002. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J. Immunol. 168: 6352-6357.
4. Behera, A. K., E. Hildebrand, R. T. Branson, G. Perides, S. Uematsu, S. Akira, and L. T. Hu. 2006. MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi. Infect. Immun. 74:1462-1470.
5. Bennett, B. L., D. T. Sasaki, B. W. Murray, E. C. O'Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S. S. Bhagwat, A. M. Manning, and D. W. Anderson. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98:13681-13686.
6. Bolz, D. D., R. S. Sundsbak, Y. Ma, S. Akira, C. J. Kirschning, J. F. Zachary, J. H. Weis, and J. J. Weis. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J. Immunol. 173:2003-2010.
7. Cabral, E. S., H. Gelderblom, R. L. Hornung, P. J. Munson, R. Martin, and A. R. Marques. 2006. Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. J. Infect. Dis. 193:849-859.
8. + T cell activation. J. Exp. Med. 195:811-823.
9. Dong, C., R. J. Davis, and R. A. Flavell. 2002. MAP kinases in the immune response. Annu. Rev. Immunol. 20:55-72.
10. Dong, C., D. D. Yang, M. Wysk, A. J. Whitmarsh, R. J. Davis, and R. A. Flavell. 1998. Defective T cell differentiation in the absence of Jnk1. Science 282:2092-2095.
11. Gupta, S., T. Barrett, A. J. Whitmarsh, J. Cavanagh, H. K. Sluss, B. Deri jard, and R. J. Davis. 1996. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15:2760-2770.
12. Gupta, S., D. Campbell, B. Derijard, and R. J. Davis. 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389-393.
13. Hajishengallis, G., A. Sharma, M. W. Russell, and R. J. Genco. 2002. Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis. Ann. Periodontol. 7:72-78.
14. Hayashi, F., K. D. Smith, A. Ozinsky, T. R. Hawn, E. C. Yi, D. R. Goodlett, J. K. Eng, S. Akira, D. M. Underhill, and A. Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-1103.
15. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
16. Hirschfeld, M., C. J. Kirschning, R. Schwandner, H. Wesche, J. H. Weis, R. M. Wooten, and J. J. Weis. 1999. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163:2382-2386.
17. Jiang, Z. H., and R. R. Koganty. 2003. Synthetic vaccines: the role of adjuvants in immune targeting. Curr. Med. Chem. 10:1423-1439.
18. Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson. 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229-3237.
19. Kawai, T., and S. Akira. 2006 TLR signaling. Cell Death Differ. 13:816-825.
20. Krutzik, S. R., M. T. Ochoa, P. A. Sieling, S. Uematsu, Y. W. Ng, A. Legaspi, P. T. Liu, S. T. Cole, P. J. Godowski, Y. Maeda, E. N. Sarno, M. V. Norgard, P. J. Brennan, S. Akira, T. H. Rea, and R. L. Modlin. 2003. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat. Med. 9:525-532.
21. Liu, N., R. R. Montgomery, S. W. Barthold, and L. K. Bockenstedt. 2004. Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice. Infect. Immun. 72:3195-3203.
22. Matsuguchi, T., T. Musikacharoen, T. Ogawa, and Y. Yoshikai. 2000. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J. Immunol. 165:5767-5772.
23. Musikacharoen, T., T. Matsuguchi, T. Kikuchi, and Y. Yoshikai. 2001. NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression. J. Immunol. 166:4516-4524.
24. Oshikawa, K., and Y. Sugiyama. 2003. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Biochem. Biophys. Res. Commun. 305:649-655.
25. Redecke, V., H. Hacker, S. K. Datta, A. Fermin, P. M. Pitha, D. H. Broide, and E. Raz. 2004. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol. 172:2739-2743.
26. Rincón, M., and R. A. Flavell. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatoiy signals in primary T lymphocytes. EMBO J. 13:4370-4381.
27. + thymocytes. J. Exp. Med. 188:1817-1830.
28. Roger, T., I. Miconnet, A. L. Schiesser, H. Kai, K. Miyake, and T. Calandra. 2005. Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 (Tlr4) gene expression. Biochem. J. 387:355-365.
29. Romics, L., Jr., A. Dolganiuc, K. Kodys, Y. Drechsler, S. Oak, A. Velayudham, P. Mandrekar, and G. Szabo. 2004. Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology 40:555-564.
30. Sabapathy, K., K. Hochedlinger, S. Y. Nam, A. Bauer, M. Karin, and E. F. Wagner. 2004. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 15:713-725.
31. Sato, K., H. Nagayama, K. Tadokoro, T. Juji, and T. A. Takahashi. 1999. Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J. Immunol. 162:3865-3872.
32. Seya, T., T. Akazawa, T. Tsujita, and M. Matsumoto. 2006. Role of Toll-like receptors in adjuvant-augmented immune therapies. Evid Based Complement Alternat Med. 3:31-38, 133-137.
33. Sluss, H. K., and R. J. Davis. 1997. Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-beta homologue decapentaplegic. J. Cell Biochem. 67:1-12.
34. Tsatsanis, C., A. Androulidaki, T. Alissafi, I. Charalampopoulos, E. Dermitzaki, T. Roger, A. Gravanis, and A. N. Margioris. 2006. Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. J. Immunol. 176:1869-1877.
35. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R. N. Kolesnick. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75-79.
36. Vermeulen, L., G. De Wilde, P. Van Damme, W. Vanden Berghe, and G. Haegeman. 2003. Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 22:1313-1324.
37. Wang, T., W. P. Lafuse, and B. S. Zwilling. 2001. NFκB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J. Immunol. 167:6924-6932.
38. Weston, C. R., A. Wong, J. P. Hall, M. E. Goad, R. A. Flavell, and R. J. Davis. 2004. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc. Natl. Acad. Sci. USA 101:14114-14119.
39. Wilson, D. J., K. A. Fortner, D. H. Lynch, R. R. Mattingly, I. G. Macara, J. A. Posada, and R. C. Budd. 1996. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur. J. Immunol. 26:989-994.
40. Wooten, R. M., Y. Ma, R. A. Yoder, J. P. Brown, J. H. Weis, J. F. Zachary, C. J. Kirschning, and J. J. Weis. 2002. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol. 168:348-355.
41. + T cells to Th1 cells requires MAP kinase JNK2. Immunity 9:575-585.