Markers of apoptosis: Methods for elucidating the mechanism of apoptotic cell death from the nervous system

BioTechniques

Volumn 32, Issue 3, 2002, Pages 648-665

  Smyth, Paul G ^a   Berman, Stephen A ^a   Bursztajn, Sherry ^a  

^a VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; NEUROLOGY; PHYSIOLOGY; PROTEINS;

NON-INFLAMMATORY CELL DEATH;

BIOTECHNOLOGY;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; GENETIC MARKER; HUMAN; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; MOLECULAR GENETICS; NERVOUS SYSTEM; NONHUMAN; PARKINSON DISEASE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036189914     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/02323dd02     Document Type: Review

References (73)

1. Pressure related apoptosis in neuronal cell lines
2. Death receptors: Signaling and modulation
3. Constitutive overexpression of Cu/Sn SOD exacerbates kainic acid-induced apoptosis of transgenic Cu/Zn SOD neurons
4. Assays for cytochrome c release from mitochondria during apoptosis
5. Programmed cell death: Does it play a role in Parkinson's disease?
6. Overexpression in neurons of human presenilin-1 or a presnilin-1 familial Alzheimer disease mutant does not enhance apoptosis
7. Poly (ADP) polymerase induction is an early signal of apoptosis in human neuroblastoma
8. Differential responses of human neuroblastoma and glioblastoma to apoptosis
9. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
10. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development
11. PKC-delta is an apoptotic lamin kinase
12. Inhibition of apoptosis induced by ischemiareperfusion prevents inflammation
13. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
14. Placement of the bc12 family member bax in the death pathway of sympathetic neurons activated by trophic factor deprivation
15. P53 and CD95 associated apoptosis in neurodegenerative disorders
16. Cell death in early neural development: Beyond the neurotrophic theory
17. Bid-induced conformational change of bax is responsible for mitochondrial cytochrome c release during apoptosis
18. Programmed cell death in neurons: Focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons
19. DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures
20. DNA damage induced neural precursor cell apoptosis requires p53 and caspase 9 but neither bax nor caspase 3
21. Additive neuroprotective effects of dextorphan and cycloheximide in rats subjected to transient focal cerebral ischemia
22. Different patterns of DNA fragmentation and degradation of nuclear matrix proteins during apoptosis induced by radiation, hyperthermia, or etoposide
23. Granulocyte colony stimulating factor inhibits neutrophil apoptosis at the local site after severe head and thoracic injury
24. Molecular mapping of the physiological cell death process: Mitochondrial events may be disordered
25. Novel nonapoptotic morphological changes in neurons of the mouse hippocampus following transient hypoxic ischemia
26. An appetite for apoptotic cells? Controversies and challenges
27. Caspase-mediated degradation of AMPA receptor subunits: A mechanism for preventing excitotoxic necrosis and ensuring necrosis
28. Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
29. Poly (ADP-ribose) polymerase-1 in the nervous system
30. Caspase 8 is an effector of dopaminergic neurons in PD, but pathway inhibition results in neuronal necrosis
31. Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons
32. The enigma of cell death in neurodegenerative disorders
33. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
34. Evidence for involvement of Bax and p53 but not caspases in radiation-induced cell death of cultured postnatal hippocampal neurons
35. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
36. Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord
37. Intact, injured, necrotic, and apoptotic cells after focal cerebral ischemia in the rat
38. Glutamate treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine
39. Staining apoptosis in paraffin sections. Advantages and limits
40. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
41. Evidence for synaptic apoptosis
42. Activation of apoptosis and its inhibition
43. Cyanide-induced apoptosis and oxidative stress in differentiated PC12 cells
44. Identification of a p53 dependent negative response element in bc12 gene
45. Tumor suppressor p53 is a regulator of bc12 and bax gene expression in vitro and in vivo
46. Young investigator's award: Induction of apoptosis following traumatic head injury in humans
47. Granzyme B-mediated apoptosis proceeds predominantly through a Bc1-2-inhibitable mitochondrial pathway
48. A model for p53 induced apoptosis
49. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
50. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains
51. Increased calpain expression is associated with apoptosis in rat spinal cord injury: Calpain inhibitor provides neuroprotection
52. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
53. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: Selective involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway
54. Adenovirus mediated gene transfer of the tumor suppressor p53 induces apoptosis in post-mitotic neurons
55. Apoptosis in cerebrovascular disease
56. The p53 tumor suppressor gene: From molecular biology to clinical investigation
57. Calpain activation in apoptosis
58. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
59. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease
60. Caspases: Enemies within
61. Radiation induced apoptosis in dorsal root ganglion neurons
62. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
63. Transgenic mice neuronally expressing baculoviral p35 are resistant to diverse types of induced apoptosis, including seizure associated neurodegeneration
64. Calpain activation is upstream of caspases in radiation induces apoptosis
65. Proapoptotic bax and bak: A requisite gateway to mitochondrial dysfunction and death
66. NMDA receptor desensitization is neuroprotective by inhibiting glutamate induced apoptotic-like death
67. Bax cleavage is mediated by calpain during drug-induced apoptosis
68. Mechanisms of neurodegenerative disorders. Part 2: Control of cell death
69. Depolarization or glutamate receptor activation blocks apoptotic death of cultured cerebellar granule cell neurons
70. Poly (ADP)ribosy)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis
71. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia
72. Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures
73. Interaction of the baculovirus anti-apoptotic protein p35 with caspases