Ribozyme inhibition of the protein kinase Cα triggers apoptosis in glioma cells

British Journal of Cancer

Volumn 80, Issue 10, 1999, Pages 1558-1564

  Leirdal, M ^a   Sioud, M ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Apoptosis; Gliomas; Protein kinase C; Ribozyme

Indexed keywords

DNA FRAGMENT; ISOENZYME; PROTEIN BCL X; PROTEIN KINASE C; RIBOZYME;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GLIOMA; HUMAN; HUMAN CELL; NUCLEOSOME; PRIORITY JOURNAL;

EID: 0032990503     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690560     Document Type: Article

References (32)

1. Blobe GC, Obeid LM and Hannun YA (1994) Regulation of protein kinase C and role in cancer biology. Cancer Met Rev 13: 411-431
2. Cameron FH and Jennings PA (1989) Specific gene suppression by engineered ribozymes in monkey cells. Proc Natl Acad Sci USA 83: 8859-8862
3. Caponigro F, French RC and Kaye SB (1997) Protein kinase C: a worthwhile target for anticancer drugs? Anti-Cancer Drugs 8: 26-33
4. Chomczynski P and Sacchi N (1987) Single step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal Biochem 162: 156-159
5. Cotten M and Birnstiel ML (1989) Ribozyme mediated destruction of RNA in vivo. EMBO J. 8: 3861-3866
6. Couldwell WT, Hinton DR, He S, Chen TC, Sebat I, Weiss MH and Law RE (1994) Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett 345: 43-46
7. Couldwell WT, Uhm JH, Antel JP and Young VW (1991) Enhanced protein kinase C activity with the growth rate of malignant gliomas in vitro. Neurosurgery 29: 880-887
8. Dean N, McKay R, Miraglia L, Howard R, Cooper S, Giddings J, Nicklin P. Meister L, Ziel R, Geiger T, Muller M and Fabbro D (1996) Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res 56: 3499-3507
9. Dekker LV and Parker PJ (1994) Protein kinase C: a question of specificity. TIBS 19: 73-77
10. Haseloff J and Gerlach WL (1988) Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334: 585-591
11. Hertel KJ, Pardi A, Uhlenbeck OL, Koizumi M, Ohtsuka E, Vesugi S, Cedergren R, Eckstein F and Gerlach WL (1992) Numbering system for the hammerhead. Nucleic Acids Res 20: 3252
12. Ikemoto H, Tani E, Matsumoto T, Nakano A and Furuyama JI (1995) Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor. J Neurosurg 83: 1008-1016
13. Kroemer G (1997) The prot-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620
14. Meggio F, Donnella-Deana A, Ruzzene M, Brunati AM, Cesaro L, Buerra B, Meyer T, Mett H, Fabbro D, Furet P, Dobrowolksa G and Pinna LA (1995) Different susceptibility of protein kinases to staurosporine inhibition: kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem 234: 317-322
15. L can confer a multidrug resistance phenotype. Blood 86: 1903-1910
16. Mischak H, Goodnight J, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG, Blumberg PM, Pierce JH and Mushinski JF (1993) Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorgenicity. J Biol Chem 268: 6090-6096
17. Newton AC (1995) Protein kinase C: structure, function, and regulation. J Biol Chem 270: 28495-28498
18. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614
19. Parker P, Kour G, Marais R, Mitchell F, Pears C, Stabel S and Webster C (1989) Protein kinase C a family affair. Mol Cell Endocrinol 65: 1-11
20. Pegoraro L, Palumbo A, Erikson J, Falda M, Giovanazzo B, Emanuel BS, Rovero G, Nowell PC and Croce CM (1984) A 14;18 and a 8;14 chromosome translocation in a cell line derived from an acute B cell leukemia. Proc Natl Acad Sci USA 81: 7166-7170
21. Qiao L, Koutsos M, Tsai LL, Kozoni V, Guzman J, Shiff SJ and Rigas B (1996) Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. Cancer Lett 107: 83-89
22. Rodin CM and Thompson CB (1997) Apoptosis and disease. Annu Rev Med 48: 267-281
23. Ruvolo PP, Deng X, Carr BK and May WS (1998) A functional role for mitochondrial protein kinase Cα in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 273: 25436-25442
24. Sarver N, Cantin EM, Chang PS, Zaia JA, Ladne PA, Stephens DA and Rossi JJ (1990) Ribozymes as potential anti HIV-1 therapeutic agents. Science 247: 1222-1225
25. Scanlon KJ, Ishida H and Kashani-Sabet M (1994) Ribozyme-mediated reversal of the multidrug-resistant phenotype. Proc Natl Acad Sci USA 91: 11123-11127
26. Sioud M (1994) Interaction between tumor necrosis factor α ribozyme and cellular proteins. J Mol Biol 242: 619-629
27. Sioud M (1996) Ribozyme modulation of lipopolysaccharide-induced tumor necrosis factor-α production by peritoneal cells in vitro and in vivo. Eur J Immunol 26: 1026-1031
28. Sioud M and Drlica K (1991) Prevention of HIV-1 integrase expression in E coli by a ribozyme. Proc Natl Acad Sci USA 88: 7303-7307
29. Sioud M and Jespersen L (1996) Enhancement of hammerhead ribozyme catalysis by glyceraldehyde-3-phosphate dehydrogenase. J Mol Biol 257: 775-789
30. Sioud M and Sorensen DR (1998) A nuclease-resistant protein kinase Cα ribozyme blocks glioma cell growth. Nature Biotech 16: 556-561
31. Sioud M, Natvig JB and Førre Ø (1992) Preformed ribozyme destroys tumour necrosis factor mRNA in human cells. J Mol Biol 223: 831-835
32. Whelan RDH and Parker PJ (1998) Loss of protein kinase C function induces an apoptotic response. Oncogene 16: 1993-1944