Stereospecific enzymatic transformation of α-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis

Journal of the American Chemical Society

Volumn 129, Issue 39, 2007, Pages 12011-12018

  Mahlert, Christoph ^a   Kopp, Florian ^a   Thirlway, Jenny ^b   Micklefield, Jason ^b   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPEPTIDE BIOSYNTHESIS; STREPTOMYCES SPECIES;

BIOSYNTHESIS; ENZYMES; PEPTIDES; STEREOCHEMISTRY;

ANTIBIOTICS;

2 OXOGLUTARIC ACID; 3 METHYLGLUTAMATE; A 54145; ALPHA KETOGLUTARATE METHYLTRANSFERASE; AMINO ACID TRANSAMINASE; ANTIBIOTIC AGENT; CALCIUM DEPENDENT ANTIBIOTIC; DAPTOMYCIN; LIPOPEPTIDE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME BINDING; IN VITRO STUDY; METHYLATION; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN ENGINEERING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOSPECIFICITY; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES FRADIAE; STREPTOMYCES ROSEOSPORUS;

AMINATION; ESCHERICHIA COLI; GLUTAMIC ACID; KETOGLUTARIC ACIDS; KINETICS; LIPOPROTEINS; METHYLATION; METHYLTRANSFERASES; STEREOISOMERISM; STREPTOMYCES COELICOLOR; SUBSTRATE SPECIFICITY;

EID: 34848822517     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja074427i     Document Type: Article

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