Chemo- and Regioselective Peptide Cyclization Triggered by the N-Terminal Fatty Acid Chain Length: The Recombinant Cyclase of the Calcium-Dependent Antibiotic from Streptomyces coelicolor

Biochemistry

Volumn 43, Issue 10, 2004, Pages 2915-2925

  Grünewald, Jan ^a   Sieber, Stephan A ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; CATALYST ACTIVITY; ENZYME KINETICS; FATTY ACIDS;

REGIOSELECTIVITY;

BIOCHEMISTRY;

AMFOMYCIN; ANTIBIOTIC AGENT; BACTERIAL ENZYME; CALCIUM DEPENDENT ANTIBIOTIC AGENT; CALCIUM DEPENDENT ANTIBIOTIC AGENT 3B; COENZYME A; CYSTEAMINE DERIVATIVE; DAPTOMYCIN; FATTY ACID; FRIULIMICIN B; LACTONE; LACTONE DERIVATIVE; MACROCYCLIC COMPOUND; N ACETYLCYSTEAMINE; PANTETHEINE PHOSPHATE; RECOMBINANT CYCLASE; RIBOSOME PROTEIN; SERINE; THIOESTER; THIOPHENOL; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; DRUG CONFORMATION; HYDROLYSIS; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; STREPTOMYCES COELICOLOR; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; CALCIUM; CATALYSIS; COENZYME A; FATTY ACIDS; IONOPHORES; LACTONES; PANTOTHENIC ACID; PEPTIDE FRAGMENTS; PEPTIDE SYNTHASES; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STEREOISOMERISM; STREPTOMYCES; THIOREDOXIN;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

EID: 12144287553     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi036140d     Document Type: Article

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