Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal α7 nicotinic acetylcholine receptor

Journal of Medicinal Chemistry

Volumn 50, Issue 19, 2007, Pages 4616-4629

  Jensen, Anders A ^a   Zlotos, Darius P ^b   Liljefors, Tommy ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALCURONIUM; ALCURONIUM DERIVATIVE; BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR BLOCKING AGENT; CARACURINE V; CATION; INDOLE DERIVATIVE; ISOCARACURINE V; LIGAND; METHYLCACONITINE; NATURAL PRODUCT; NITROGEN; PYRAZINO[1,2 A;4,5 A']DIINDOLE DERIVATIVE; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; TOXIFERINE; TOXIFERINE DERIVATIVE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING COMPETITION; BINDING SITE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ACONITINE; ALKALOIDS; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; HUMANS; ION CHANNELS; LIGANDS; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NEURONS; NICOTINIC ANTAGONISTS; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34648836438     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070574f     Document Type: Article

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