Allosteric site on muscarinic acetylcholine receptors: A single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

Molecular Pharmacology

Volumn 61, Issue 1, 2002, Pages 160-168

  Buller, Stefan ^a,b   Zlotos, Darius Paul ^c   Mohr, Klaus ^b   Ellis, John ^a,d  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCURONIUM; ALKANE; AMINO ACID; AMMONIUM DERIVATIVE; ASPARAGINE; CARACURINE 5; EPITOPE; GALLAMINE; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHIMERA; DISSOCIATION; DNA FLANKING REGION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

ALKALOIDS; ALLOSTERIC REGULATION; ANIMALS; COS CELLS; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS; POINT MUTATION; RECEPTORS, MUSCARINIC; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0036143908     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.1.160     Document Type: Article

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