6H,13H-Pyrazino[1,2-a;4,5-a′]diindole analogs: Probing the pharmacophore for allosteric ligands of muscarinic M2 receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1481-1485

  Zlotos, Darius P ^a   Tränkle, Christian ^b   Abdelrahman, Aliaa ^b   Gündisch, Daniela ^b   Radacki, Krzysztof ^a   Braunschweig, Holger ^a   Mohr, Klaus ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Allosteric ligands; Muscarinic M2 receptors

Indexed keywords

6H,13H PYRAZINO[1,2 A;4,5 A']DIINDOLE; CARACURINE; DIALLYLCARACURINE; DIMETHYLCARACURINE; INDOLE DERIVATIVE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR AGONIST; NICOTINIC RECEPTOR; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; X RAY DIFFRACTION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; INDOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLES; NEUROMUSCULAR BLOCKING AGENTS; PYRAZINES; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M2; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO; X-RAY DIFFRACTION;

EID: 32044465991     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.030     Document Type: Article

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