Novel pathways of protein secretion

Molecular Chaperones and Cell Signalling

Volumn , Issue , 2005, Pages 45-60

  Chimini, Giovanna ^a   Rubartelli, Anna ^b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34548851468     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511546310.004     Document Type: Chapter

References (91)

1. de Lima Pimenta A, Blight M A, Chervaux C and Holland I B. Protein secretion in Gram negative bacteria. In Kuchler, K., Rubartelli, A. and Holland, B. (Eds.) Unusual Secretory Pathways: From Bacteria to Man. Chapman & Hall Landes Bioscience, New York/Austin, TX 1997, pp 1-48.
2. Cleves A E, Cooper D N, Barondes S H and Kelly R B. A new pathway for protein export in Saccharomyces cerevisiae.J Cell Biol 1996, 133: 1017-1026.
3. Kuchler K and Egner R. Unusual protein secretion and translocation pathways in yeast: implication of ABC transporters. In Kuchler, K., Rubartelli, A. and Holland, B. (Eds.) Unusual Secretory Pathways: From Bacteria to Man. Chapman & Hall Landes Bioscience, New York/Austin, TX 1997, pp 49-86.
4. Rubartelli A and Sitia R. Secretion of mammalian proteins that lack a signal sequence. In Kuchler, K., Rubartelli, A. and Holland, B. (Eds.) Unusual Secretory Pathways: From Bacteria to Man. Chapman & Hall Landes Bioscience, New York/Austin, TX 1997, pp 87-115.
5. Rubartelli A, Cozzolino F, Talio M and Sitia R. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBOJ 1990, 9: 1503-1510.
6. Rubartelli A, Bajetto A, Allavena G, Wollman E and Sitia R. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J Biol Chem 1992, 267:24161-24164.
7. Dinarello C A. Proinflammatory cytokines. Chest 2000, 118: 503-508.
8. Werman A, Werman-Venkent R, White R, Lee J K, Werman B, Krelin Y, Voronov E, Dinarello C A, and Apte R N. The precursor form of IL1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A, 2004, 101: 2434-2439.
9. Dinarello C A and Fantuzzi G. Interleukin-18 and host defense against infection. J Infect Dis 2003, 187: S370-S384.
10. Fantuzzi G and Dinarello C A. Interleukin-18 and interleukin-113: two cytokine substrates for ICE (caspase-1). J Clin Immunol 1999, 19: 1-11.
11. Laliberte R E, EgglerJ and Gabel C A. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem 1999, 274: 36944-36951.
12. Cruishank W, Kornfeld H and Center D M. Interleukin-16. J Leuk Biol 2000, 67: 757-766.
13. Christofori G. The role of fibroblast growth factors in tumour progression and angiogenesis. In Bicknell, R., Lewis, C. E. and Ferrara, N. (Eds.) Tumour Angiogenesis. Oxford University Press, Oxford, UK 1997, pp 201-238.
14. Bikfalvi A, Savona C, Perollet C and Javerzat S. New insights in the biology of fibroblast growth factor-2. Angiogenesis 1998, 1: 155-173.
15. Tsai S J, Wu M H, Chen H M, Chuang P C and Wing L Y. Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology 2002, 143: 2715-2721.
16. Sleeman M W, Anderson K D, Lambert P D, Yancopoulos G D and Wiegand S J. The ciliary neurotrophic factor and its receptor, CNTFR alpha. Pharm Acta Helv 2000, 74: 265-272.
17. Calandra T. Macrophage migration inhibitory factor and host innate immune responses to microbes. Scand J Infect Dis 2003, 35: 573-576.
18. Ko Y G, Park H, Kim T, Lee J W, Park S G, Seol W, Kim J E, Lee W H, Kim S H, Park J E and Kim S. A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. J Biol Chem 2001, 276: 23028-23033.
19. Berger A C, Alexander H R, Tang G, Wu P S, Hewitt S M, Turner E, Kruger E, Figg W D, Grove A, Kohn E, Stern D and Libutti S K. Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis. Microvasc Res 2000, 60: 70-80.
20. Rescher U, Zobiack N and Gerke V. Intact Ca2+-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells. J Cell Sci 2000, 113: 3931-3938.
21. Solito E, Nuti S and Parente L. Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells. Br J Pharmacol 1994, 112: 347-348.
22. Christmas P, Callaway J, Fallon J, Jones J and Haigler H T. Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem 1991, 266: 2499-2507.
23. Tsutsumi S, Yanagawa T, Shimura T, Fukumori T, Hogan V, Kuwano H and Raz A. Regulation of cell proliferation by autocrine motility factor/phosphoglucose iso- merase signaling. J Biol Chem 2003, 278: 32165-32172.
24. Arner E S and Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. EurJ Biochem 2000, 267: 6102-6109.
25. Rabinovich G A, Baum L G, Tinari N, Paganelli R, Natoli C, Liu F T and Iacobelli S. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol 2002, 23: 313-320.
26. Rabinovich G A, Rubinstein N and Toscano M A. Role of galectins in inflammatory and immunomodulatory processes. Biochim Biophys Acta 2002, 1572: 274-284.
27. Sano H, Hsu D K, Apgar J R, Yu L, Sharma B B, Kuwabara I, Izui S and Liu F T. Critical role of galectin-3 in phagocytosis by macrophages. J Clin Invest 2003, 112: 389-397.
28. Griffin M, Casadio R and Bergamini C M. Transglutaminases: Nature’s biological glues. Biochem J 2002, 368: 377-396.
29. Grundmann U, Amann E, Zettlmeissl G and Kupper H A. Characterization of cDNA coding for human factor XIIIa. Proc Natl Acad Sci USA 1986, 83: 8024-8028.
30. Wang H, Bloom O, Zhang M, Vishnubhakat J M, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue K R, Faist E, Abraham E, Andersson J, Andersson U, Molina P E, Abumrad N N, Sama A and Tracey KJ. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999, 285: 248-251.
31. Maizel A, Tassetto M, Filhol O, Cochet C, Prochiantz A and Joliot A. Engrailed homeoprotein secretion is a regulated process. Development 2002, 129: 3545-3553.
32. Maizel A, Bensaude O, Prochiantz A and Joliot A. A short region of itshomeodomain is necessary for engrailed nuclear export and secretion. Development 1999, 126: 3183-3190.
33. Dagher S F, Wang J L and Patterson RJ. Identification of galectin-3 as a factor in pre-mRNA splicing. Proc Natl Acad Sci USA 1995, 92: 1213-1217.
34. Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H and Bernhagen J. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature 2000, 408: 211-216.
35. Vareli K, Frangou-Lazaridis M, van der Kraan I, Tsolas O and van Driel R. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. Exp Cell Res 2000, 257: 152-161.
36. Hannappel E and Huff T. The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. Vit Horm 2003, 66: 257-296.
37. Focher F and Spadari S. Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy. Cur Cancer Drug Targets 2001, 1: 141-153.
38. Jackson A, Tarantini F, Gamble S, Friedman S and Maciag T. The release offibroblast growth factor-1 from NIH 3T3 cells in response to temperature involves the function of cysteine residues. J Biol Chem 1995, 270: 33-36.
39. Tarantini F, Gamble S, Jackson A and Maciag T. The cysteine residue responsible for the release of fibroblast growth factor-1 residues in a domain independent of the domain for phosphatidylserine binding. J Biol Chem 1995, 270: 29039-29042.
40. Balklava Z, Verderio E, Collighan R, Gross S, Adams J and Griffin M. Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts: the active- state conformation of the enzyme does not affect cell motility but is important for its secretion. J Biol Chem 2002, 277: 16567-16575.
41. Reiness C G, Seppa M J, Dion D M, Sweeney S, Foster D N and Nishi R. Chick ciliary neurotrophic factor is secreted via a nonclassical pathway. Mol Cell Neurosci 2001, 17: 931-944.
42. Menon R P and Hughes R C. Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex. Eur J Biochem 1999, 264: 569-576.
43. Gong H C, Honjo Y, Nangia-Makker P, Hogan V, Mazurak N, Bresalier R S and Raz A. The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells. Cancer Res 1999, 59: 6239-6245.
44. Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Porto A, Bachi A, Rubartelli A, Agresti A and Bianchi M E. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 2003, 22: 5551-5560.
45. Haga A, Niinaka Y and Raz A. Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein. Biochim Biophys Acta 2000, 1480: 235-244.
46. Stevenson F T, Bursten S L, Fanton C, Locksley R M and Lovett D H. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc Natl Acad Sci USA 1993, 90: 7245-7249.
47. Cooper D N and Barondes S H. Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J Cell Biol 1990, 110: 1681-1691.
48. Lindstedt R, Apodaca G, Barondes S H, Mostov K E and Leffler H. Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway. J Biol Chem 1993, 268: 11750-11757.
49. Hermo L and Jacks D. Nature’s ingenuity: bypassing the classical secretory route via apocrine secretion. Mol Reprod Dev 2002, 63: 394-410.
50. Steinhoff M, Eicheler W, Holterhus P M, Rausch U, Seitz J and Aumuller G. Hormonally induced changes in apocrine secretion of transglutaminase in the rat dorsal prostate and coagulating gland. Eur J Cell Biol 1994, 65: 49-59.
51. Eickhoff R, Wilhelm B, Renneberg H, Wennemuth G, Bacher M, Linder D, Bucala R, Seitz J and Meinhardt A. Purification and characterization of macrophage migration inhibitory factor as a secretory protein from rat epididymis: evidences for alternative release and transfer to spermatozoa. Mol Med 2001, 7: 27-35.
52. MacKenzie A, Wilson H L, Kiss-Toth E, Dower S K, North R A and Surprenant A. Rapid secretion of interleukin-113 by microvesicle shedding. Immunity 2001, 15: 825-835.
53. Murk J L, Stoorvogel W, Kleijmeer MJ and Geuze HJ. The plasticity of multivesicular bodies and the regulation of antigen presentation. Sem Cell Dev Biol 2002, 13: 303-311.
54. Johnstone R M, Adam M, Hammond J R, Orr L and Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem 1987, 262: 9412-9420.
55. Thery C, Zitvogel L and Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002, 2: 569-579.
56. Thery C, Boussac M, Visron P, Ricciardi-Castagnoli P, Raposo G, Garin G and Amigorena S. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 2001, 166: 7309-7318.
57. Fink A L. Chaperone-mediated protein folding. Physiol Rev 1999, 79: 425-449.
58. Holland I B, Benhabdelhak H, Young J, de Lima Pimenta A, Schmitt L and Blight M A. Bacterial ABC transporters involved in protein translocation. In Holland, I. B. (Ed.) ABC Proteins:from Bacteria to Man. Academic Press, London/San Diego 2003, pp 209-242.
59. Prudovsky I, Bagala C, Tarantini F, Mandinova A, Soldi R, Bellum S and Maciag T. The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export. J Cell Biol 2002, 158: 201-208.
60. McNew J A and Goodman J M. An oligomeric protein is imported into peroxisomes in vivo. J Cell Biol 1994, 127: 1245-1257.
61. Cuervo A M, Mann L, Bonten E J, d’Azzo A and Dice J F. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J 2003, 22: 47-59.
62. Dean M, Hamon Y and Chimini G. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 2001, 42: 1007-1017.
63. Hamon Y, Luciani M F, Becq F, Verrier B, Rubartelli A and Chimini G. Interleukin- 113 secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1. Blood 1997, 90:2911-2915.
64. Chapman L P, Epton MJ, Buckingham J C, Morris J F and Christian H C. Evidence for a role of the adenosine 5'-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells. Endocrinology 2003, 144: 1062-1073.
65. Flieger O, Engling A, Bucala R, Lue H, Nickel W and Bernhagen J. Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett 2003, 551: 78-86.
66. Schafer T, Zentgraf H, Zehe C, Brugger B, Bernhagen J and Nickel W. Unconventional protein secretion: direct translocation of fibroblast growth factor 2 across the plasma membrane of mammalian cells. J Biol Chem 2003, 279: 6244-6251.
67. Oliani S M, Damazo A S and Perretti M. Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. Med Inflamm 2002, 11: 287-292.
68. Qu Z, Kayton RJ, Ahmadi P, Liebler J M, Powers M R, Planck S R and Rosenbaum J T. Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granules. Morphological evidence for bfgf release through degranulation. J Histochem Cytochem 1998, 46: 1119-1128.
69. Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K and Bucala R. Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol Med 1995, 1: 781-788.
70. Joliot A, Maizel A, Rosenberg D, Trembleau A, Dupas S, Volovitch M and Prochiantz A. Identification of a signal sequence necessary for the unconventional secretion of Engrailed homeoprotein. Cur Biol 1998, 8: 856-863.
71. Gardella S, Andrei C, Ferrera D, Lotti L V, Torrisi M R, Bianchi M E and Rubartelli A. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle- mediated secretory pathway. EMBO Rep 2002, 3: 995-1001.
72. Andrei C, Dazzi C, Lotti L, Torrisi M R, Chimini G and Rubartelli A. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome- related vesicles. Mol Biol Cell 1999, 10: 1463-1475.
73. Gardella S, Andrei C, Poggi A, Zocchi M R and Rubartelli A. Control of interleukin-18 secretion by dendritic cells: role of calcium influxes. FEBS Lett 2000, 481: 245-248.
74. Blott E J and Griffiths G M. Secretory lysosomes. Nat Rev Mol Cell Biol 2002, 3: 122-131.
75. Sesaki H, Wong E F and Siu C H. The cell adhesion molecule DdCAD-1 in Dictyostelium is targeted to the cell surface by a nonclassical transport pathway involving contractile vacuoles. J Cell Biol 1997, 138: 939-951.
76. Holland I B. ABC Proteins:from Bacteria to Man. Academic Press, London/San Diego: 2003.
77. Andrei C, Margiocco P, Poggi A, Lotti L V, Torrisi M R, Rubartelli A. Phospholipases C and A2 control lysosome - mediated IL-1beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci USA 2004, 101: 9745-9750.
78. Perregaux D G, McNiff P, Laliberte R, Conklyn M and Gabel C A. ATP acts as an agonist to promote stimulus-induced secretion of IL-1|3 and IL-18 in human blood. J Immunol 2000, 165: 4615-4623.
79. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz J M, Morelli A, Torboli M, Bolog- nesi G and Baricordi O R. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 2001, 97: 587-600.
80. Gardella S, Andrei C, Costigliolo S, Poggi A, Zocchi M R and Rubartelli A. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J Leuk Biol 1999, 66: 237-241.
81. Gardella S, Andrei C, Lotti L V, Poggi A, Torrisi M R, Zocchi M R and Rubartelli A. CD8+ T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-113 and cathepsin D. Blood 2001, 98: 2152-2159.
82. Kamogashira T, Masui Y, Ohmoto Y, Hirato T, Nagamura K, Mizuno K, Hong Y M, Kikumoto Y, Nakai S and Hirai Y. Site-specific mutagenesis of the human interleukin-113 gene: structure-function analysis of the cysteine residues. Biochem Biophys Res Comm 1988, 150: 1106-1114.
83. Pei D S, Fu Y, Sun Y F and Zhao H R. Site-directed mutagenesis of the cysteines of human IL-18 and its effect on IL-18 activity. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2002, 34: 57-61.
84. Ortega S, Schaeffer M T, Soderman D, DiSalvo J, Linemeyer D L, Gimenez-Gallego G and Thomas K A. Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor. J Biol Chem 1991, 266: 5842-5846.
85. Cho M and Cummings R D. Galectin-1, a β-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization. J Biol Chem 1995, 270: 5198-5206.
86. Kleemann R, Kapurniotu A, Mischke R, Held J and Bernhagen J. Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF. EurJ Biochem 1999, 261: 753-766.
87. Angelini G, Gardella S, Ardy M, Ciriolo M R, Filomeni G, Di Trapani G, Clarke F, Sitia R and Rubartelli A. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Nat Acad Sci USA 2002, 99: 1491-1496.
88. Rogelj S, Weinberg R A, Fanning P and Klagsbrun M. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature 1988, 331: 173-175.
89. Sloan I S, Horowitz P M and Chirgwin J M. Rapid secretion by a nonclassical pathway of overexpressed mammalian mitochondrial rhodanese. J Biol Chem 1994, 269: 27625-27630.
90. Tanudji M, Hevi S and Chuck S L. Improperly folded green fluorescent protein is secreted via a non-classical pathway. J Cell Sci 2002, 115: 3849-3857.
91. Lue H, Kleemann R, Calandra T, Roger T and Bernhagen J. Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease. Microbes Infect 2002, 4: 449-460.