Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells

Journal of Leukocyte Biology

Volumn 66, Issue 2, 1999, Pages 237-241

  Gardella, Stefania ^a   Andrei, Cristina ^a   Costigliolo, Sara ^a   Poggi, Alessandro ^a   Zocchi, M Raffaella ^b   Rubartelli, Anna ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Antigen presenting cells; Cytokines; Immune response; Mixed lymphocyte reaction; Tetanus toxoid

Indexed keywords

CD40 ANTIGEN; INTERLEUKIN 18; TETANUS TOXOID;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0032799227     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.2.237     Document Type: Article

References (25)

1. Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., Akita, K., Namba, M., Tanabe, F., Konishi, K., Fukuda, S., Kurimoto, M. (1995) Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378, 88-91.
2. Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., Torigoe, K., Tanimoto, T., Fukuda, S., Ikeda, M., Okamura, H., Kurimoto, M. (1996) Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156, 4274-4279.
3. Rubartelli, A., Sitia, R. (1997) Secretion of mammalian proteins that lack a signal sequence. In Unusual Secretory Pathways: From Bacteria to Man (K. Kuchler, A. Rubartelli, B. Holland, eds.) Austin, TX: R. G. Landes, 87-104.
4. Gu, J., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R. A., Sato, V., Harding, M. W., Livingston, D. J., Su, M. S.-S. (1997) Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme. Science 275, 206-209.
5. Ghayur, T., Banerjee, S., Ugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D., Allen, H. (1997) Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386, 619-623.
6. Micallef, M., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., Fukuda, S., Kurimoto, M. (1996) IFN-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol. 26, 1647-1651.
7. Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y, Okamoto, I., Usui, M., Ikeda, M., Kurimoto, M. (1997) IFN-γ-inducing factor (IGIF) is a co-stimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158, 1541-1550.
8. Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., Autenrieth, I. B. (1998) IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol. 160, 299-307.
9. Munder, M., Mallo, M., Eichmann, K., Modolell, M. (1998) Murine macrophages secrete interferon-γ upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187, 2103-2108.
10. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
11. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., Alber, G. (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory activity: T-T help via APC activation. J. Exp. Med. 184, 747-752.
12. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N., Schuler, G. (1996) High level of IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and down regulation by IL-4 and IL-10. J. Exp. Med. 184, 741-747.
13. Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
14. 3 integrin and requires intracellular and extracellular calcium. Eur. J. Immunol. 27, 1893-1900.
15. Sallusto, F., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen to th MHC class II compartment. Downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
16. + peripheral blood mononuclear cells migrate across endothelium and give rise to immunostimulatory dendritic cells. J. Immunol. 160, 2675-2683.
17. Hamon, Y., Luciani, M. F., Becq, F., Verrier, B., Rubartelli, A., Chimini, G. (1997) Interleukin-1β secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1. Blood 90, 2911-2915.
18. Konishi, K., Tanabe, F., Taniguchi, M., Yamauchi, H., Tanimoto, T., Ikeda, M., Orita, K., Kurimoto, M. (1998) A simple and sensitive bioassay for the detection of human interleukin-18/interferon-γ-inducing factor using human myelomonocytic KG-1 cells. J. Immunol. Meth. 209, 187-191.
19. + T cell responses. Immunol. Today 17, 410-414.
20. Irmler, M., Hertig, S., MacDonald, H. R., Sadoul, R., Becherer, J. D., Proudfoot, A., Solari, R., Tschopp, J. (1995) Granzyme A is an interleukin-1β converting enzyme. J. Exp. Med. 181, 1917-1922.
21. Torigoe, K., Ushio, S., Okura, T., Kobayashi, S., Taniai, M., Kunikata, T., Murakami, T., Sanou, O., Kojima, H., Fujii, M., Ohta, T., Ikeda, M., Ikegami, H., Kurimoto, M. (1997) Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272, 25737-25742.
22. Lamont, A. G., Adorini, L. (1996) IL-12: a key cytokine in immune regulation. Immunol. Today 17, 214-217.
23. van Kooten, C., Banchereau, J. (1997) Functions of CD40 on B cells, dendritic cells and other cells. Curr. Opin. Immunol. 9, 330-337.
24. Rubartelli, A., Bajetto, A., Allavena, G., Cozzolino, F., Sitia, R. (1993) Post-translational regulation of interleukin 1β secretion. Cytokine 5, 117-124.
25. Perregaux, D., Gabel, C. A. (1994) Interleukin-1β maturation and release in response to ATP and nigericin. J. Biol. Chem. 269, 15195-15203.