Chemical modification of conotoxins to improve stability and activity

ACS Chemical Biology

Volumn 2, Issue 7, 2007, Pages 457-468

  Craik, David J ^a   Adams, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CONOTOXIN AULB; ALPHA CONOTOXIN GID; ALPHA CONOTOXIN LML; ALPHA CONOTOXIN MII; ALPHA CONOTOXIN SI; ALPHA CONOTOXIN VC1.1; AM 336; CALCIUM CHANNEL N TYPE; CGX 1160; CONANTOKIN G; CONOTOXIN; CONTULAKIN G; CYCLOSPORIN; MARINE TOXIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROTENSIN RECEPTOR; NICOTINIC RECEPTOR; NORADRENALIN TRANSPORTER; OMEGA CONOTOXIN; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN MVIIA; POTASSIUM CHANNEL; SEROTONIN 3 RECEPTOR; SODIUM CHANNEL; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR; X CONOTOXIN MRLA; XEN 2174; DISULFIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANALGESIC ACTIVITY; CHEMICAL MODIFICATION; CHRONIC PAIN; CLINICAL TRIAL; CONUS SNAIL; CYCLIZATION; DRUG ABSORPTION; DRUG DESIGN; DRUG HALF LIFE; DRUG ISOLATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; MOLECULAR STABILITY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION; TOXIN ANALYSIS; CHEMISTRY; HALF LIFE TIME; MOLECULAR GENETICS;

GASTROPODA;

AMINO ACID SEQUENCE; CONOTOXINS; DISULFIDES; HALF-LIFE; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 34548643963     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700091j     Document Type: Review

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