Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel

Molecular Diversity

Volumn 8, Issue 2, 2004, Pages 127-134

  Schroeder, Christina I ^a   Smythe, Mark L ^a   Lewis, Richard J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

conotoxin; Macrocylces; N type voltage gated calcium channels; Pentapeptides; Peptidomimetics

Indexed keywords

AM 336; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CYCLOPEPTIDE; DEXTRO AMINO ACID; OMEGA CONOTIC CVID; OMEGA CONOTOXIN; OMEGA CONOTOXIN MVIIA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHRONIC PAIN; DRUG DESIGN; DRUG SYNTHESIS; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT;

ANIMALS; BIOCHEMISTRY; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ION CHANNEL GATING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR MIMICRY; OMEGA-CONOTOXINS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VENOMS;

EID: 3543031622     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MODI.0000025656.79632.86     Document Type: Article

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