Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells

Journal of Cellular Physiology

Volumn 213, Issue 1, 2007, Pages 126-136

  Chiba, Norika ^a   Masuda, Akio ^a   Yoshikai, Yasunobu ^b   Matsuguchi, Tetsuya ^c  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FUMONISIN B1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 5; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ALLERGY; ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; BONE MARROW CELL; CELL FUNCTION; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE EXACERBATION; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOMODULATION; INFLAMMATION; MACROPHAGE; MAST CELL; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; CELL DEGRANULATION; DNA PRIMERS; FEMALE; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-5; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-AKT; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 34548515043     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21101     Document Type: Article

References (64)

1. Akira S, Takeda K. 2004. Toll-like recepor signaling. Nat Rev Immunol 4:499-511.
2. Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B. 2004. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 431:1007-1011.
3. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187.
4. Bourbon NA, Sandirasegarane L, Kester M. 2002. Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: Implications for growth arrest. J Biol Chem 277:3286-3292.
5. Bourbon NA, Yun J, Berkey D, Wang Y, Kester M. 2001. Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions. Am J Physiol Cell Physiol 280:C1403-C1411.
6. Carl G, Simon J, Gear ARL. 1998. Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. Biochemistry 37:2059-2069.
7. Cavaillon JM. 1994. Cytokines and macrophages. Biomed Pharmacother 48:445-453.
8. Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA. 2003. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278:10297-10303.
9. Ching TT, Hsu AL, Johnson AJ, Chen CS. 2001. Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism. J Biol Chem 276:14814-14820.
10. Duan W, Aguinaldo Datiles AM, Leung BP, Vlahos CJ, Wong WS. 2005. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol 5:495-502.
11. Echtenacher B, Männel DN, Hültner L. 1996. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381:75.
12. Galli SJ, Gordon JR, Wershil BK. 1991. Cytokine production by mast cells and basophils. Curr Opin Immunol 3:86S.
13. Galli SJ, Maurer M, Lantz CS. 1999. Mast cells as sentinels of innate immunity. Curr Opin Immunol 11:53.
14. Gidwani A, Brown HA, Holowka D, Baird B. 2003. Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcepsilonRI. J Cell Sci 116:3177-3187.
15. Goswami R, Singh D, Phillips G, Kilkus J, Dawson G. 2005. Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. J Neurosci Res 81:541-550.
16. Hambleton J, Weinstein SL, Lem L, DeFranco AL. 1996. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci 93:2774.
17. Han JJ, Lee D, Bibbs L, Ulevitch RJ. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808.
18. Hannun YA, Obeid LM. 2002. The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind. J Biol Chem 277:25847-25850.
19. Hsu YW, Chi KHWCH, Lin WW. 2001. Ceramide inhibits lipopolysaccharide- mediated nitric oxide synthase and cyclooxigenase-2 induction in macrophages: Effects on protein kinases and transcription factors. J Immunol 166:5388.
20. Katsuo ROK, Ahmadi K, White S, Timms J, Water-field MD. 2001. Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 17:615-675.
21. Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HA, Postma D,. Danzig M, Cuss F, Pauwels RA. 2003. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study. Am J Respir Crit Care Med 167:1655-1659.
22. Kitatani K, Akiba S, Hayama M, Sato T. 2001. Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D2 production in RBL-2H3 Cells. Arch Biochem Biophys 395:208.
23. Kolesnick R. 2002. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110:3-8.
24. Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS, Lee YC. 2003. Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J Clin Invest 111:1083-1092.
25. Laffargue M, Calvez R, Finan P, Trifilieff A, Barbier M, Altruda F, Hirsch E, Wymann MP. 2002. Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 16:441-451.
26. Lakics V, Vogel SN. 1998. Lipopolysaccharide and ceramide use divergent signaling pathway to induce cell death in murine macrophages. J Immunol 161:2490.
27. Laouini D, Alenius H, Bryce P, Oettgen H, Tsitsikov E, Geha RS. 2003. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest 112:1058-1066.
28. Leal-Berumen I, Conlon P, Marshall JS. 1994. IL-6 production by rat peritoneal mast cells in not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide. J Immunol 152:5486.
29. Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. 2006. Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. Faseb J 20:455-465.
30. Liu MK, Herrera-Velit P, Brownsey RW, Reiner NE. 1994. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 153:2642.
31. MacKinchan ML, DeFranco AL. 1999. Role of ceramide in lipopolysaccharide (LPS)-induced signaling; LPS increases ceramide rather than acting as a structural homologue. J Biol Chem 274:1767.
32. Mackman N, Brand K, Edgington TS. 1999. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activation protein I and nuclear factor KB binding sites. J Exp Med 174.
33. Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, Xing Z, Jordana M, Larsen GL, Gelfand EW. 2000. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci USA 97:6007-6012.
34. Marquardt DL, Alongi JL, Walker LL. 1996. The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production. J Immunol 156:1942-1945.
35. Martin M, Rehani K, Jope RS, Michalek SM. 2005. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6:777-784.
36. Masuda A, Yoshikai Y, Aiba K, Matsuguchi T. 2002. Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38. J Immunol 169:3801.
37. Matsuguchi T, Zhao Y, Lilly MB, Kraft AS. 1997. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor a subunit is essential for both GM-CSF-mediated growth and differentiation. J Biol Chem 272:17450.
38. Matsui K, Nishikawa A. 2002. Lipoteichoic acid from Staphylococcus aureus induces Th2-prone dermatitis in mice sensitized percutaneously with an allergen. Clin Exp Allergy 32:783-788.
39. Medvedev AE, Blanco JCG, Qureshi N, Vogel SN. 1999. Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. J Biol Chem 274:9342.
40. Metcalfe DD, Baram D, Mekori YA. 1997. Mast cells. Physiol Rev 77:1033.
41. Nakamura Y, Nakashima S, Ojio K, Banno Y, Miyata H, Nozawa Y. 1996. Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells. J Immunol 156:256-262.
42. O'Byrne PM, Inman MD, Adelroth E. 2004. Reassessing the Th2 cytokine basis of asthma. Trends Pharmacol Sci 25:244-248.
43. Ojaniemi M, Glumoff V, Harju K, Liljeroos M, Vuori K, Hallman M. 2003. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol 33:597-605.
44. Pahan K, Sheikh FG, Khan M, Namboodiri AMS, Singh I. 1998. Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem 273:2591.
45. Platzer C, Fritsch E, Eisner T, Lehmann MH, Volk HD, Prosch S. 1999. Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells. Eur J Immunol 29:3098-3104.
46. Resjo S, Goransson O, Harndahl L, Zolnierowicz S, Manganiello V, Degerman E. 2002. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal 14:231-238.
47. Schubert KM, Scheid MP, Duronio V. 2000. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J Biol Chem 275:13330-13335.
48. Shapira L, Sylvia VL, Halabi A, Soskolne WA, Van Dyke TE, Dean DD, Boyan BD, Schwartz Z. 1997. Bacterial lipopolysaccharide induces early and late activation of protein kinase C in inflammatory macrophages by selective activation of PKC-epsilon. Biochem Biophys Res Commun 240:629-634.
49. Simon CGJr, Gear AR. 1998. Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. Biochemistry 37:2059-2069.
50. Speigel S, Foster D, Kolesnick R. 1996. Signal transduction through lipid second messengers. Curr Opin Cell Biol 8:159.
51. Spergel JM, Mizoguchi E, Oettgen H, Bhan AK, Geha RS. 1999. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103:1103-1111.
52. Stratford S, DeWald DB, Summers SA. 2001. Ceramide dissociates 3'′phosphoinositide production from pleckstrin homology domain translocation. Biochem J 354:359-368.
53. Strohmeier GR, Walsh JH, Klings ES, Farber HW, Cruikshank WW, Center DM, Fenton MJ. 2001. Lipopolysaccharide binding protein potentiates airway reactivities in a murine model of allergic asthma. J Immunol 166:2063.
54. Summers SA, Garza LA, Zhou H, Birnbaum MJ. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 18:5457-5464.
55. Supayatura V, Ushio H, Nakao A, OkumuraK, Ra C, Ogawa H. 2001. Protective role of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol I67:2250.
56. Tigani B, Hannon JP, Mazzoni L, Fozard JR. 2001. Effects of wortmannin on airways inflammation induced by allergen in actively sensitised Brown Norway rats. Eur J Pharmacol 433:217-223.
57. Tournoy KG, Kips JC, Pauwels RA. 2000. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy 30:775-783.
58. Ulevitch RJ, Tobias PS. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin Annu Rev Immunol 13:437.
59. Vincenti MP, Burrell TA, Taffet SM. 1992. Regulation of NF-κB activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester. J Cell Physiol 150:204.
60. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. 1998. Interleukin-13: Central mediator of allergic asthma. Science 282:2258-2261.
61. Yang X, Wang S, Fan Y, Han X. 2000. IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 30:382-391.
62. Zhang TY, Daynes RA. 2007. Glucocorticoid conditioning of myeloid progenitors enhances TLR4 signaling via negative regulation of the phosphatidylinositol 3-kinase-Akt pathway. J Immunol (Baltimore, MD) 178:2517-2526.
63. Zhou H, Summers SA, Birnbaum MJ, Pittman RN. 1998. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J Biol Chem 273:16568-16575.
64. Zinda MJ, Vlahos CJ, Lai MT. 2001. Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells. Biochem Biophys Res Commun 280:1107-1115.