Reassessing the Th2 cytokine basis of asthma

Trends in Pharmacological Sciences

Volumn 25, Issue 5, 2004, Pages 244-248

  O'Byrne, Paul M ^a,b   Inman, Mark D ^a   Adelroth, Ellinor ^c  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALTRAKINCEPT; ANTIASTHMATIC AGENT; CORTICOSTEROID; CYTOKINE; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; SCH 55700;

ALLERGIC ASTHMA; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFICACY; HELPER CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; TH2 CELL;

EID: 2142754440     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.03.008     Document Type: Article

References (38)

1. Sears M.R., et al. Atopy in childhood. I. Gender and allergen related risks for development of hay fever and asthma. Clin. Exp. Allergy. 23:1993;941-948
2. Roquet A., et al. Combined antagonist of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics. Am. J. Respir. Crit. Care Med. 155:1997;1856-1863
3. Gauvreau G.M., et al. Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am. J. Respir. Crit. Care Med. 160:1999;640-647
4. Gauvreau G.M., et al. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge in atopic asthmatics. Am. J. Respir. Crit. Care Med. 161:2000;1473-1478
5. Dolovich J., et al. Late cutaneous allergic responses in isolated IgE-dependent responses. J. Allergy Clin. Immunol. 52:1973;38-46
6. Gupta S., et al. Lymphocyte subpopulations, serum IgE and total eosinophil counts in patients with bronchial asthma. Clin. Exp. Immunol. 22:1975;438-445
7. Parish W.E., Luckhurst E. Eosinophilia VI, spontaneous synthesis of chemokinetics, chemotactic, complement receptor-inducing activities for eosinophils by bronchial T lymphocytes of asthmatic-bronchitic patients. Clin. Allergy. 12:1982;475-488
8. Mosmann T.R., et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:1986;2348-2357
9. Bossie A., et al. Activation of murine B cells from different tissues with different mitogens. Isotype distribution of secreted immunoglobulins in the presence and absence of IL-4-containing T cell supernatants. J. Mol. Cell. Immunol. 3:1987;221-226
10. Masinovsky B., et al. IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular adhesion molecule-1. J. Immunol. 145:1990;2886-2895
11. Bentley A., et al. Tissue eosinophilia and increased numbers of cell expressing mRNA for IL-4 and IL-5 occur in asthma but not bronchiectasis. J. Allergy Clin. Immunol. 101:1998;S107
12. Zangrilli J.G., et al. sVcam-1 Levels after segmental antigen challenge correlate with eosinophil influx, IL-4 and IL-5 production, and the late-phase response. Am. J. Respir. Crit. Care Med. 151:1995;1346-1353
13. Sanderson C.J. Interleukin-5: an eosinophil growth and activation factor. Dev. Biol. Stand. 69:1988;23-29
14. Clutterbuck E.J., Sanderson C.J. Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL-5): production of functionally active eosinophils from normal human bone marrow. Blood. 71:1988;646-651
15. Lopez A.F., et al. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167:1988;219-224
16. Wang J.M., et al. Recombinant human interleukin 5 is a selective eosinophil chemoattractant. Eur. J. Immunol. 19:1989;701-705
17. Sanderson C.J. The biological role of interleukin 5. Int. J. Cell Cloning. 8:1990;147-153
18. Del Prete G.F., et al. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur. J. Immunol. 23:1993;1445-1449
19. Del Prete G.F. Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy. 47:1992;450-455
20. Broide D.H., et al. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation. J. Clin. Invest. 90:1992;1414-1424
21. Gauvreau G.M., et al. Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am. J. Respir. Crit. Care Med. 160:1999;640-647
22. Sulakvelidze I., et al. Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low dose allergen challenge in atopic asthmatics. Eur. Respir. J. 11:1998;821-827
23. Hallden G., et al. Increased levels of IL-5 positive peripheral blood eosinophils and lymphocytes in mild asthmatics after allergen inhalation provocation. Clin. Exp. Allergy. 29:1999;595-603
24. Sehmi R., et al. Allergen-induced increases in IL-5 a subunit expression on bone marrow derived CD34+ cells from asthmatic subjects: a novel marker of progenitor cell commitment towards eosinophil differentiation. J. Clin. Invest. 100:1997;2466-2475
25. Wills-Karp M., et al. Interleukin-13: central mediator of allergic asthma. Science. 282:1998;2258-2261
26. Leckie M.J., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2000;2144-2148
27. O'Byrne P.M., et al. The trials and tribulations of IL-5, eosinophils, and allergic asthma. J. Allergy Clin. Immunol. 108:2001;503-508
28. Kips J., et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167:2003;1655-1659
29. Borish L.C., et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. 160:1999;1816-1823
30. Borish L.C., et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 107:2001;963-970
31. Turner M.O., et al. Exacerbations of asthma without sputum eosinophilia. Thorax. 50:1995;1057-1061
32. Flood-Page P.T., et al. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am. J. Respir. Crit. Care Med. 167:2003;199-204
33. Busse W.W. Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. Am. J. Respir. Crit. Care Med. 164:2001;S12-S17
34. Litonjua A.A., et al. Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Ann. Allergy Asthma Immunol. 90:2003;422-428
35. Koh Y.I., et al. Relationship between changes in interferon-gamma production by peripheral blood T cells and changes in peak expired flow rate in patients with chronic asthma. Clin. Exp. Allergy. 32:2002;1734-1738
36. Brown V., et al. T cell cytokine profile in childhood asthma. Thorax. 58:2003;311-316
37. Krug N., et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am. J. Respir. Cell Mol. Biol. 14:1996;319-326
38. Smart J.M., Kemp A.S. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin. Exp. Allergy. 32:2002;796-802