22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1761, Issue 12, 2006, Pages 1515-1522

  Tranheim Kase, Eili ^a   Andersen, Bård ^a   Nebb, Hilde I ^a   Rustan, Arild C ^a   Hege Thoresen, G ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

22 hydroxycholesterol; human myotubes; lipid metabolism; LXR

Indexed keywords

22 HYDROXYCHOLESTEROL; ABC TRANSPORTER A1; ACYL COENZYME A DESATURASE; CD36 ANTIGEN; DIACYLGLYCEROL; FAS LIGAND; FATTY ACID; FATTY ACID SYNTHASE; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID METABOLISM; LIPOGENESIS; MYOTUBE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; UPREGULATION; VALIDATION PROCESS;

ANIMALS; ANTIGENS, CD95; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; HYDROXYCHOLESTEROLS; LIGANDS; LIPID METABOLISM; MUSCLE FIBERS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SULFONAMIDES; TRANSFECTION; TRIGLYCERIDES;

EID: 34548487854     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2006.09.010     Document Type: Article

References (49)

1. Duplus E., and Forest C. Is there a single mechanism for fatty acid regulation of gene transcription?. Biochem. Pharmacol. 64 (2002) 893-901
2. Repa J.J., Liang G., Ou J., Bashmakov Y., Lobaccaro J.M., Shimomura I., Shan B., Brown M.S., Goldstein J.L., and D.J. Mangelsdorf, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14 (2000) 2819-2830
3. Edwards P.A., Kennedy M.A., and Mak P.A. LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vasc. Pharmacol. 38 (2002) 249-256
4. Song C., Kokontis J.M., Hiipakka R.A., and Liao S. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 10809-10813
5. Apfel R., Benbrook D., Lernhardt E., Ortiz M.A., Salbert G., and Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14 (1994) 7025-7035
6. Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., Staels B., Auwerx J., Laville M., and Vidal H. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46 (1997) 1319-1327
7. Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., and Mangelsdorf D.J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9 (1995) 1033-1045
8. Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., Schwendner S., Wang S., Thoolen M., Mangelsdorf D.J., Lustig K.D., and Shan B. Role of LXRs in control of lipogenesis. Genes Dev. 14 (2000) 2831-2838
9. Janowski B.A., Grogan M.J., Jones S.A., Wisely G.B., Kliewer S.A., Corey E.J., and Mangelsdorf D.J. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 266-271
10. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383 (1996) 728-731
11. Spencer T.A., Li D., Russel J.S., Collins J.L., Bledsoe R.K., Consler T.G., Moore L.B., Galardi C.M., McKee D.D., Moore J.T., Watson M.A., Parks D.J., Lambert M.H., and Willson T.M. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. J. Med. Chem. 44 (2001) 886-897
12. Forman B.M., Ruan B., Chen J., Schroepfer Jr. G.J., and Evans R.M. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 10588-10593
13. Shimano H., Horton J.D., Hammer R.E., Shimomura I., Brown M.S., and Goldstein J.L. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98 (1996) 1575-1584
14. Shimano H., Shimomura I., Hammer R.E., Herz J., Goldstein J.L., Brown M.S., and Horton J.D. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Invest. 100 (1997) 2115-2124
15. Shimomura I., Shimano H., Horton J.D., Goldstein J.L., and Brown M.S. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99 (1997) 838-845
16. Bobard A., Hainault I., Ferre P., Foufelle F., and Bossard P. Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development. J. Biol. Chem. 280 (2005) 199-206
17. Hampton R.Y. Proteolysis and sterol regulation. Annu. Rev. Cell. Dev. Biol. 18 (2002) 345-378
18. Hegarty B.D., Bobard A., Hainault I., Ferre P., Bossard P., and Foufelle F. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 791-796
19. Sun L.P., Li L., Goldstein J.L., and Brown M.S. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J. Biol. Chem. 280 (2005) 26483-26490
20. Wang X., Sato R., Brown M.S., Hua X., and Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77 (1994) 53-62
21. Sheng Z., Otani H., Brown M.S., and Goldstein J.L. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 935-938
22. Eberle D., Hegarty B., Bossard P., Ferre P., and Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86 (2004) 839-848
23. Laffitte B.A., Repa J.J., Joseph S.B., Wilpitz D.C., Kast H.R., Mangelsdorf D.J., and Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 507-512
24. Achouri Y., Hegarty B.D., Allanic D., Becard D., Hainault I., Ferre P., and Foufelle F. Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c. Biochimie 87 (2005) 1149-1155
25. Joseph S.B., Laffitte B.A., Patel P.H., Watson M.A., Matsukuma K.E., Walczak R., Collins J.L., Osborne T.F., and Tontonoz P. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem. 277 (2002) 11019-11025
26. Peet D.J., Turley S.D., Ma W., Janowski B.A., Lobaccaro J.M., Hammer R.E., and Mangelsdorf D.J. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93 (1998) 693-704
27. Tobin K.A., Ulven S.M., Schuster G.U., Steineger H.H., Andresen S.M., Gustafsson J.A., and Nebb H.I. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem. 277 (2002) 10691-10697
28. Dressel U., Allen T.L., Pippal J.B., Rohde P.R., Lau P., and Muscat G.E. The Peroxisome Proliferator Activated Receptor {beta}/{delta} agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol. Endocrinol. 17 (2003) 2477-2493
29. Muscat G.E., Wagner B.L., Hou J., Tangirala R.K., Bischoff E.D., Rohde P., Petrowski M., Li J., Shao G., Macondray G., and Schulman I.G. Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors. J. Biol. Chem. 277 (2002) 40722-40728
30. Kase E.T., Wensaas A.J., Aas V., Hojlund K., Levin K., Thoresen G.H., Beck-Nielsen H., Rustan A.C., and Gaster M. Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway. Diabetes 54 (2005) 1108-1115
31. Henry R.R., Abrams L., Nikoulina S., and Ciaraldi T.P. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 44 (1995) 936-946
32. Gaster M., Beck-Nielsen H., and Schroder H.D. Proliferation conditions for human satellite cells. The fractional content of satellite cells. APMIS 109 (2001) 726-734
33. Gaster M., Rustan A.C., Aas V., and Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes 53 (2004) 542-548
34. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
35. Tobin K.A., Steineger H.H., Alberti S., Spydevold O., Auwerx J., Gustafsson J.A., and Nebb H.I. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol. Endocrinol. 14 (2000) 741-752
36. Megeney L.A., and Rudnicki M.A. Determination versus differentiation and the MyoD family of transcription factors. Biochem. Cell. Biol. 73 (1995) 723-732
37. Olson E.N., Brennan T.J., Chakraborty T., Cheng T.C., Cserjesi P., Edmondson D., James G., and Li L. Molecular control of myogenesis: antagonism between growth and differentiation. Mol. Cell. Biochem. 104 (1991) 7-13
38. Wyzykowski J.C., Winata T.I., Mitin N., Taparowsky E.J., and Konieczny S.F. Identification of novel MyoD gene targets in proliferating myogenic stem cells. Mol. Cell. Biol. 22 (2002) 6199-6208
39. Cornelison D.D., and Wold B.J. Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells. Dev. Biol. 191 (1997) 270-283
40. Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53 Suppl 1 (2004) S43-S50
41. Auwerx J. PPARgamma, the ultimate thrifty gene. Diabetologia 42 (1999) 1033-1049
42. Berger J., and Moller D.E. The mechanisms of action of PPARs. Annu. Rev. Med. 53 (2002) 409-435
43. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., Spiegelman B.M., and Mortensen R.M. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4 (1999) 611-617
44. Miyazaki M., and Ntambi J.M. Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins, Leukot. Essent. Fat. Acids 68 (2003) 113-121
45. Ntambi J.M., and Miyazaki M. Recent insights into stearoyl-CoA desaturase-1. Curr. Opin. Lipidol. 14 (2003) 255-261
46. Bjorkhem I., and Diczfalusy U. Oxysterols: friends, foes, or just fellow passengers?. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 734-742
47. Fu X., Menke J.G., Chen Y., Zhou G., MacNaul K.L., Wright S.D., Sparrow C.P., and Lund E.G. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem. 276 (2001) 38378-38387
48. Quinet E.M., Savio D.A., Halpern A.R., Chen L., Miller C.P., and Nambi P. Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor. J. Lipid Res. 45 (2004) 1929-1942
49. Sparrow C.P., Baffic J., Lam M.H., Lund E.G., Adams A.D., Fu X., Hayes N., Jones A.B., Macnaul K.L., Ondeyka J., Singh S., Wang J., Zhou G., Moller D.E., Wright S.D., and Menke J.G. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J. Biol. Chem. 277 (2002) 10021-10027