Fcγ receptor IIB-deficient mice develop goodpasture's syndrome upon immunization with type IV collagen: A novel murine model for autoimmune glomerular basement membrane disease

Journal of Experimental Medicine

Volumn 191, Issue 5, 2000, Pages 899-905

  Nakamura, Akira ^a,b   Yuasa, Takae ^a,b   Ujike, Azusa ^a,b   Ono, Masao ^a,b   Nukiwa, Toshihiro ^a   Ravetch, Jeffrey V ^c   Takai, Toshiyuki ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alveolar glomerular basement membrane; Autoimmunity; Fc receptor; Goodpasture's syndrome; Type IV collagen

Indexed keywords

COLLAGEN TYPE 4; FC RECEPTOR; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M ANTIBODY; AUTOANTIBODY; COLLAGEN; FC GAMMA RECEPTOR IIB; LEUKOCYTE ANTIGEN;

ALLERGIC GLOMERULONEPHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DISEASE SIMULATION; FEMALE; GOODPASTURE SYNDROME; HISTOPATHOLOGY; IMMUNE COMPLEX DEPOSITION; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REPRODUCIBILITY; ANIMAL; BLEEDING; BLOOD; DISEASE MODEL; GENETICS; GLOMERULONEPHRITIS; GLOMERULUS; IMMUNOLOGY; LUNG; MOUSE; MOUSE MUTANT; PATHOLOGY;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; ANTIGENS, CD; AUTOANTIBODIES; COLLAGEN; DISEASE MODELS, ANIMAL; HEMORRHAGE; KIDNEY GLOMERULUS; LUNG; MICE; MICE, MUTANT STRAINS; RECEPTORS, IGG;

EID: 0034610854     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.5.899     Document Type: Article

References (22)

1. The significance of certain pulmonary lesions in relation at the etiology of influenza
2. Goodpasture syndrome
3. Goodpasture's syndrome (pulmonary haemorrhage associated with glomerulonephritis)
4. The role of antiglomerular basement membrane antibody in the pathogenesis of human glomerulonephritis
5. Alveolar basement membrane: Molecular properties of the noncollagenous domain (hexamer) of collagen IV and its reactivity with Goodpasture autoantibodies
6. Antiglomerular basement membrane antibody mediated disease in the British Isles
7. Identification of the Goodpasture antigen as the α3 (IV) chain of collagen IV
8. Anti-glomerular basement membrane glomerulonephritis
9. Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney
10. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with α3 (IV) chain of the type IV collagen
11. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T-cell-mediated immunity in mice
12. b mice susceptible to collagen-induced arthritis
13. Augmented humoral and anaphylactic responses in FcγRII-deficient mice
14. Cytotoxic antibodies trigger inflammation through Fc receptors
15. FcR γ chain deletion results in pleiotrophic effector cell defects
16. Goodpasture syndrome: Molecular and clinical advances
17. Recurrent Goodpasture's disease due to a monoclonal IgA-kappa circulating antibody
18. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors
19. Goodpasture's syndrome and idiopathic pulmonary hemorrhage
20. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes
21. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγIIB
22. SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis