Anti-Aβ1-11 antibody binds to different β-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers

Journal of Biological Chemistry

Volumn 282, Issue 31, 2007, Pages 22376-22386

  Mamikonyan, Grigor ^a   Necula, Mihaela ^b   Mkrtichyan, Mikayel ^a   Ghochikyan, Anahit ^a   Petrushina, Irina ^b   Movsesyan, Nina ^a   Mina, Erene ^b   Kiyatkin, Anatoly ^c   Glabe, Charles G ^b   Cribbs, David H ^b   Agadjanyan, Michael G ^a,b  

^a INSTITUTE FOR MOLECULAR MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID SPECIES; NONFIBRILLAR CONFORMATIONS; SUBSTOICHIOMETRIC CONCENTRATIONS;

BINDING ENERGY; CONFORMATIONS; OLIGOMERS; TOXIC MATERIALS; VACCINES;

ANTIBODIES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-11]; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EMBRYO; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; STOICHIOMETRY;

AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CYTOKINES; EPITOPES; HIPPOCAMPUS; HUMANS; IMMUNE SYSTEM; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR CONFORMATION; PROTEIN BINDING; SPLEEN; T-LYMPHOCYTES;

MUS;

EID: 34547955761     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700088200     Document Type: Article

References (68)

1. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10, 373-403
2. Price, D. L., and Sisodia, S. S. (1994) Annu. Rev. Med. 45, 435-446
3. Nicoll, J. A., Yamada, M., Frackowiak, J., Mazur-Kolecka, B., and Weller, R. O. (2004) Neurobiol. Aging 25, 589-597; discussion 603-584
4. Zlokovic, B. V. (2005) Trends Neurosci. 28, 202-208
5. Selkoe, D. J. (1991) Neuron 6, 487-498
6. Selkoe, D. J. (1994) J. Neuropath. Exp. Neurol. 53, 438-447
7. Esler, W. P., and Wolfe, M. S. (2001) Science 293, 1449-1454
8. Hardy, J. A., and Higgins, G. A. (1992) Science 256, 184-185
9. Sisodia, S. S., and Price, D. L. (1995) FASEB. J. 9, 366-370
10. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
11. Lorenzo, A., and Yankner, B. A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12243-12247
12. Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., and Cotman, C. W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 7951-7955
13. Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., and Klein, W. L. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10417-10422
14. Lesne, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., and Ashe, K. H. (2006) Nature 440, 352-357
15. Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., and Ashe, K. H. (2005) Nat. Neurosci. 8, 79-84
16. Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., and Rowan, M. J. (2005) Nat. Med. 11, 556-561
17. Lee, E. B., Leng, L. Z., Zhang, B., Kwong, L., Trojanowski, J. Q., Abel, T., and Lee, V. M. (2006) J. Biol. Chem. 281, 4292-4299
18. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D., and Seubert, P. (1999) Nature 400, 173-177
19. Schenk, D. (2002) Nat. Rev. Neurosci. 3, 824-828
20. Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., and Arendash, G. W. (2000) Nature 408, 982-985
21. Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., St George-Hyslop, P., and Westaway, D. (2000) Nature 408, 979-982
22. Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., and Morris, R. G. M. (2000) Nature 408, 975-979
23. Bard, F., Cannon, C., Barbour, R., Burke, R. L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Lieberburg, I., Motter, R., Nguyen, M., Soriano, F., Vasquez, N., Weiss, K., Welch, B., Seubert, P., Schenk, D., and Yednock, T. (2000) Nat. Med. 6, 916-919
24. DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M., and Holtzman, D. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8850-8855
25. DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M., and Holtzman, D. M. (2002) Science 295, 2264-2267
26. McLaurin, J., Cecal, R., Kierstead, M. E., Tian, X., Phinney, A. L., Manea, M., French, J. E., Lambermon, M. H., Darabie, A. A., Brown, M. E., Janus, C., Chishti, M. A., Horne, P., Westaway, D., Fraser, P. E., Mount, H. T., Przybylski, M., and St. George-Hyslop, P. (2002) Nat. Med. 8, 1263-1269
27. Solomon, B., Koppel, R., Hanan, E., and Katzav, T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 452-455
28. Solomon, B., Koppel, R., Frankel, D., and Hanan-Aharon, E. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4109-4112
29. Johnson-Wood, K., Lee, M., Motter, R., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M., Tan, H., Games, D., Lieberburg, I., Schenk, D., Seubert, P., and McConlogue, L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1550-1555
30. Legleiter, J., Czilli, D. L., Gitter, B., DeMattos, R. B., Holtzman, D. M., and Kowalewski, T. (2004) J. Mol. Biol. 335, 997-1006
31. Frenkel, D., Katz, O., and Solomon, B. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 11455-11459
32. Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003) Neuron 39, 409-421
33. Agadjanyan, M. G., Ghochikyan, A., Petrushina, I., Vasilevko, V., Movsesyan, N., Mkrtichyan, M., Saing, T., and Cribbs, D. H. (2005) J. Immunol. 174, 1580-1586
34. Oddo, S., Caccamo, A., Kitazawa, M., Tseng, B. P., and LaFerla, F. M. (2003) Neurobiol. Aging 24, 1063-1070
35. Cribbs, D. H., Ghochikyan, A., Tran, M., Vasilevko, V., Petrushina, I., Sadzikava, N., Kesslak, P., Kieber-Emmons, T., Cotman, C. W., and Agadjanyan, M. G. (2003) Int. Immunol. 15, 505-514
36. Petrushina, I., Tran, M., Sadzikava, N., Ghochikyan, A., Vasilevko, V., Agadjanyan, M. G., and Cribbs, D. H. (2003) Neurosci. Lett. 338, 5-8
37. Ghochikyan, A., Vasilevko, V., Petrushina, I., Tran, M., Sadzikava, N., Babikyan, D., Movsesyan, N., Tian, W., Ross, T. M., Cribbs, D. H., and Agadjanyan, M. G. (2003) Eur. J. Immunol. 33, 3232-3241
38. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Science 300, 486-489
39. Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., and Younkin, S. G. (2001) J. Neurosci. 21, 372-381
40. Oddo, S., Vasilevko, V., Caccamo, A., Kitazawa, M., Cribbs, D. H., and LaFerla, F. M. (2006) J. Biol. Chem. 281, 39413-39423
41. Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., and LaFerla, F. M. (2004) Neuron 43, 321-332
42. Nielsen, L., Khurana, R., Coats, A., Frokjaer, S., Brange, J., Vyas, S., Uversky, V. N., and Fink, A. L. (2001) Biochemistry 40, 6036-6046
43. Uversky, V. N., Li, J., and Fink, A. L. (2001) J. Biol. Chem. 276, 10737-10744
44. Necula, M., Chirita, C. N., and Kuret, J. (2003) J. Biol. Chem. 278, 46674-46680
45. Necula, M., Chirita, C. N., and Kuret, J. (2005) Biochemistry 44, 10227-10237
46. Harper, J. D., and Lansbury, P. T., Jr. (1997) Annu. Rev. Biochem. 66, 385-407
47. Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., and Lansbury, P. T., Jr. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 763-767
48. Chirita, C. N., and Kuret, J. (2004) Biochemistry 43, 1704-1714
49. Naiki, H., Hasegawa, K., Yamaguchi, I., Nakamura, H., Gejyo, F., and Nakakuki, K. (1998) Biochemistry 37, 17882-17889
50. LeVine, H., III (1993) Protein Sci. 2, 404-410
51. Finkelman, F. D., Holmes, J., Katona, I. M., Urban, J. F., Beckmann, M. P., Park, L. S., Schooley, K. A., Coffman, R. L., Mossmann, T. R., and Paul, W. E. (1990) Annu. Rev. Immunol. 8, 303-333
52. Schenk, D., Hagen, M., and Seubert, P. (2004) Curr. Opin. Immunol. 16, 599-606
53. Nicoll, J. A., Wilkinson, D., Holmes, C., Steart, P., Markham, H., and Weller, R. O. (2003) Nat. Med. 9, 448-452
54. Ferrer, I., Rovira, M. B., Guerra, M. L. S., Rey, M. J., and Costa-Jussa, F. (2004) Brain Pathol. 14, 11-20
55. Masliah, E., Hansen, L., Adame, A., Crews, L., Bard, F., Lee, C., Seubert, P., Games, D., Kirby, L., and Schenk, D. (2005) Neurology 64, 129-131
56. Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., Wollmer, M. A., Umbricht, D., de Quervain, D. J., Hofmann, M., Maddalena, A., Papassotiropoulos, A., and Nitsch, R. M. (2003) Neuron 38, 547-554
57. Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., and Orgogozo, J. M. (2005) Neurology 64, 1553-1562
58. Fox, N. C., Black, R. S., Gilman, S., Rossor, M. N., Griffith, S. G., Jenkins, L., and Koller, M. (2005) Neurology 64, 1563-1572
59. Bayer, A. J., Bullock, R., Jones, R. W., Wilkinson, D., Paterson, K. R., Jenkins, L., Millais, S. B., and Donoghue, S. (2005) Neurology 64, 94-101
60. Hock, C., Konietzko, U., Papassotiropoulos, A., Wollmer, A., Streffer, J., Von Rotz, R. C., Davey, G., Moritz, E., and Nitsch, R. M. (2002) Nat. Med. 8, 1270-1275
61. Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., Selkoe, D. J., Palmour, R. M., and Ervin, F. R. (2004) Am. J. Pathol. 165, 283-297
62. Chirita, C., Necula, M., and Kuret, J. (2004) Biochemistry 43, 2879-2887
63. Racke, M. M., Boone, L. I., Hepburn, D. L., Parsadainian, M., Bryan, M. T., Ness, D. K., Piroozi, K. S., Jordan, W. H., Brown, D. D., Hoffman, W. P., Holtzman, D. M., Bales, K. R., Gitter, B. D., May, P. C., Paul, S. M., and DeMattos, R. B. (2005) J. Neurosci. 25, 629-636
64. Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Science 294, 1346-1349
65. Zhu, M., Rajamani, S., Kaylor, J., Han, S., Zhou, F., and Fink, A. L. (2004) J. Biol. Chem. 279, 26846-26857
66. Klunk, W. E., Pettegrew, J. W., and Abraham, D. J. (1989) J. Histochem. Cytochem. 37, 1273-1281
67. Deshpande, A., Mina, E., Glabe, C., and Busciglio, J. (2006) J. Neurosci. 26, 6011-6018
68. Patton, R. L., Kalback, W. M., Esh, C. L., Kokjohn, T. A., Van Vickle, G. D., Luehrs, D. C., Kuo, Y. M., Lopez, J., Brune, D., Ferrer, I., Masliah, E., Newel, A. J., Beach, T. G., Castano, E. M., and Roher, A. E. (2006) Am. J. Pathol. 169, 1048-1063