Mitochondrial morphology and protein import-A tight connection?

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 5-6, 2006, Pages 414-421

  Stojanovski, Diana ^a   Rissler, Michael ^a   Pfanner, Nikolaus ^a   Meisinger, Chris ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Mitochondria; Protein assembly; Protein import; Saccharomyces cerevisiae

Indexed keywords

CELL ORGANELLE; CELL STRUCTURE; GENE EXPRESSION; GENE TRANSLOCATION; MEMBRANE TRANSPORT; MITOCHONDRION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SURFACE PROPERTY;

ANIMALS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PROTEIN TRANSPORT;

EID: 33745738540     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.02.008     Document Type: Review

References (63)

1. Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R., Meyer H.E., Schönfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., and Meisinger C. The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 13207-13212
2. Schatz G., and Dobberstein B. Common principles of protein translocation across membranes. Science 271 (1996) 1519-1526
3. Neupert W. Protein import into mitochondria. Annu. Rev. Biochem. 66 (1997) 863-917
4. Rehling P., Brandner K., and Pfanner N. Mitochondrial import and the twin-pore translocase. Nat. Rev. Mol. Cell Biol. 5 (2004) 519-530
5. Koehler C.M. New developments in mitochondrial assembly. Annu. Rev. Cell Dev. Biol. 20 (2004) 309-335
6. Hill K., Model K., Ryan M.T., Dietmeier K., Martin F., Wagner R., and Pfanner N. Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature 395 (1998) 516-521
7. Künkele K.P., Heins S., Dembowski M., Nargang F.E., Benz R., Thieffry M., Walz J., Lill R., Nussberger S., and Neupert W. The preprotein translocation channel of the outer membrane of mitochondria. Cell 93 (1998) 1009-1019
8. van Wilpe S., Ryan M.T., Hill K., Maarse A.C., Meisinger C., Brix J., Dekker P.J.T., Moczko M., Wagner R., Meijer M., Guiard B., Hönlinger A., and Pfanner N. TOM22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature 401 (1999) 485-489
9. Rapaport D. Finding the right organelle. Targeting signals in mitochondrial outer membrane proteins. EMBO Rep. 4 (2003) 948-952
10. Pfanner N., Wiedemann N., Meisinger C., and Lithgow T. Assembling the mitochondrial outer membrane. Nat. Struct. Mol. Biol. 11 (2004) 1044-1048
11. Wiedemann N., Kozjak V., Chacinska A., Schönfisch B., Rospert S., Ryan M.T., Pfanner N., and Meisinger C. Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424 (2003) 565-571
12. Kozjak V., Wiedemann N., Milenkovic D., Lohaus C., Meyer H.E., Guiard B., Meisinger C., and Pfanner N. An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J. Biol. Chem. 278 (2003) 48520-48523
13. Paschen S.A., Waizenegger T., Stan T., Preuss M., Cyrklaff M., Hell K., Rapaport D., and Neupert W. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature 426 (2003) 862-866
14. Gentle I., Gabriel K., Beech P., Waller R., and Lithgow T. The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. J. Cell Biol. 164 (2004) 19-24
15. Milenkovic D., Kozjak V., Wiedemann N., Lohaus C., Meyer H.E., Guiard B., Pfanner N., and Meisinger C. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J. Biol. Chem. 279 (2004) 22781-22785
16. Waizenegger T., Habib S.J., Lech M., Mokranjac D., Paschen S.A., Hell K., Neupert W., and Rapaport D. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. EMBO Rep. 5 (2004) 704-709
17. Ishikawa D., Yamamoto H., Tamura Y., Moritoh K., and Endo T. Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J. Cell Biol. 166 (2004) 621-627
18. Model K., Meisinger C., Prinz T., Wiedemann N., Truscott K.N., Pfanner N., and Ryan M.T. Multi-step assembly of the protein import channel of the mitochondrial outer membrane. Nat. Struct. Biol. 8 (2001) 361-370
19. Hoppins S.C., and Nargang F.E. The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes. J. Biol. Chem. 279 (2004) 12396-12405
20. Wiedemann N., Truscott K.N., Pfannschmidt S., Guiard B., Meisinger C., and Pfanner N. Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J. Biol. Chem. 279 (2004) 18188-18194
21. Voulhoux R., Bos M.P., Geurtsen J., Mols M., and Tommassen J. Role of a highly conserved bacterial protein in outer membrane protein assembly. Science 299 (2003) 262-265
22. Lutz T., Neupert W., and Herrmann J.M. Import of small Tim proteins into the mitochondrial intermembrane space. EMBO J. 22 (2003) 4400-4408
23. Chacinska A., Pfannschmidt S., Wiedemann N., Kozjak V., Sanjuán-Szklarz L.K., Schulze-Specking A., Truscott K.N., Guiard B., Meisinger C., and Pfanner N. Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J. 23 (2004) 3735-3746
24. Naoé M., Ohwa Y., Ishikawa D., Ohshima C., Ishikawa S., Yamamoto H., and Endo T. Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space. J. Biol. Chem. 279 (2004) 47815-47821
25. Mesecke N., Terziyska N., Kozany C., Baumann F., Neupert W., Hell K., and Herrmann J.M. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell 121 (2005) 1059-1069
26. Rissler M., Wiedemann N., Pfannschmidt S., Gabriel K., Guiard B., Pfanner N., and Chacinska A. The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. J. Mol. Biol. 353 (2005) 485-492
27. Allen S., Balabanidou V., Sideris D.P., Lisowsky T., and Tokatlidis K. Erv 1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c. J. Mol. Biol. 353 (2005) 937-944
28. Herrmann J.M., and Hell K. Chopped, trapped or tacked-protein translocation into the IMS of mitochondria. Trends Biochem. Sci. 30 (2005) 205-211
29. Lee J., Hofhaus G., and Lisowsky T. Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase. FEBS Lett. 477 (2000) 62-66
30. Lange H., Lisowsky T., Gerber J., Mühlenhoff U., Kispal G., and Lill R. An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep. 2 (2001) 715-720
31. Jensen R.E., and Johnson A.E. Opening the door to mitochondrial protein import. Nat. Struct. Biol. 8 (2001) 1008-1010
32. Pfanner N., and Geissler A. Versatility of the mitochondrial protein import machinery. Nat. Rev. Cell Biol. 2 (2001) 339-349
33. Chacinska A., Lind M., Frazier A.E., Dudek J., Meisinger C., Geissler A., Sickmann A., Meyer H.E., Truscott K.N., Guiard B., Pfanner N., and Rehling P. Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120 (2005) 817-829
34. Geissler A., Chacinska A., Truscott K.N., Wiedemann N., Brandner K., Sickmann A., Meyer H.E., Meisinger C., Pfanner N., and Rehling P. The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell 111 (2002) 507-518
35. Yamamoto H., Esaki M., Kanamori T., Tamura Y., Nishikawa S., and Endo T. Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Cell 111 (2002) 519-528
36. Mokranjac D., Paschen S.A., Kozany C., Prokisch H., Hoppins S.C., Nargang F.E., Neupert W., and Hell K. Tim50, a novel component of the TIM23 protein translocase of mitochondria. EMBO J. 22 (2003) 816-825
37. Truscott K.N., Kovermann P., Geissler A., Merlin A., Meijer M., Driessen A.J., Rassow J., Pfanner N., and Wagner R. A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat. Struct. Biol. 8 (2001) 1074-1082
38. Frazier A.E., Dudek J., Guiard B., Voos W., Li Y., Lind M., Meisinger C., Geissler A., Sickmann A., Meyer H.E., Bilanchone V., Cumsky M.G., Truscott K.N., Pfanner N., and Rehling P. Pam16 has an essential role in the mitochondrial protein import motor. Nat. Struct. Mol. Biol. 11 (2004) 226-233
39. Kozany C., Mokranjac D., Sichting M., Neupert W., and Hell K. The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase. Nat. Struct. Mol. Biol. 11 (2004) 234-241
40. D'Silva P.R., Schilke B., Walter W., and Craig E.A. Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 12419-12424
41. Burri L., Vascotto K., Fredersdorf S., Tiedt R., Hall M.N., and Lithgow T. Zim17, a novel zinc finger protein essential for protein import into mitochondria. J. Biol. Chem. 279 (2004) 50243-50249
42. Yamamoto H., Momose T., Yatsukawa Y., Ohshima C., Ishikawa D., Sato T., Ohwa Y., and Endo T. Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone protein that facilitates protein translocation across the inner membrane. FEBS Lett. 579 (2005) 507-511
43. Sichting M., Mokranjac D., Azem A., Neupert W., and Hell K. Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J. 24 (2005) 1046-1056
44. Sanjuán Szklarz L.K., Guiard B., Rissler M., Wiedemann N., Kozjak V., van der Laan M., Lohaus C., Marcus K., Meyer H.E., Chacinska A., Pfanner N., and Meisinger C. Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J. Mol. Biol. 351 (2005) 206-218
45. Rehling P., Model K., Brandner K., Kovermann P., Sickmann A., Meyer H.E., Kühlbrandt W., Wagner R., Truscott K.N., and Pfanner N. Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299 (2003) 1747-1751
46. Koehler C.M. The small Tim proteins and the twin Cx3C motif. Trends Biochem. Sci. 29 (2004) 1-4
47. Wiedemann N., Frazier A.E., and Pfanner N. The protein import machinery of mitochondria. J. Biol. Chem. 279 (2004) 14473-14476
48. Meisinger C., Rissler M., Chacinska A., Milenkovic D., Kozjak V., Schönfisch B., Lohaus C., Meyer H.E., Yaffe M.P., Guiard B., Wiedemann N., and Pfanner N. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev. Cell 7 (2004) 61-71
49. Sogo L.F., and Yaffe M.P. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126 (1994) 1361-1373
50. Altmann K., and Westermann B. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol. Biol. Cell 16 (2005) 5410-5417
51. Boldogh I.R., Nowakowski D.W., Yang H.C., Chung H., Karmon S., Royes P., and Pon L.A. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol. Biol. Cell 14 (2003) 4618-4627
52. Habib S.J., Waizenegger T., Lech M., Neupert W., and Rapaport D. Assembly of the TOB complex of mitochondria. J. Biol. Chem. 280 (2005) 6434-6440
53. Dimmer K.S., Fritz S., Fuchs F., Messerschmitt M., Weinbach N., Neupert W., and Westermann B. Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell 13 (2002) 847-853
54. Dietmeier K., Hönlinger A., Bömer U., Dekker P.J., Eckerskorn C., Lottspeich F., Kübrich M., and Pfanner N. Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature 388 (1997) 195-200
55. Dekker P.J.T., Ryan M.T., Brix J., Müller H., Hönlinger A., and Pfanner N. Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol. Cell. Biol. 18 (1998) 6515-6524
56. Waizenegger T., Schmitt S., Zivkovic J., Neupert W., and Rapaport D. Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep. 6 (2005) 57-62
57. Becher D., Kricke J., Stein G., and Lisowsky T. A mutant for the yeast scERV1 gene displays a new defect in mitochondrial morphology and distribution. Yeast 15 (1999) 1171-1181
58. Herlan M., Bornhovd C., Hell K., Neupert W., and Reichert A.S. Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J. Cell Biol. 165 (2004) 167-173
59. Kawai A., Nishikawa S., Hirata A., and Endo T. Loss of the mitochondrial Hsp70 functions causes aggregation of mitochondria in yeast cells. J. Cell Sci. 114 (2001) 3565-3574
60. Herlan M., Vogel F., Bornhovd C., Neupert W., and Reichert A.S. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278 (2003) 27781-27788
61. Sesaki H., Southard S.M., Hobbs A.E., and Jensen R.E. Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1 processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondria fusion. Biochem. Biophys. Res. Commun. 308 (2003) 276-283
62. Esser K., Tursun B., Ingenhoven M., Michaelis G., and Pratje E. A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J. Mol. Biol. 323 (2002) 835-843
63. McQuibban G.A., Saurya S., and Freeman M. Mitochondrial membrane remodeling regulated by a conserved rhomboid protease. Nature 423 (2003) 537-541