Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: Actions of oxLDL

Antioxidants and Redox Signaling

Volumn 9, Issue 9, 2007, Pages 1519-1534

  Levitan, Irena ^a,c   Gooch, Keith J ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Rush Presbyterian SLMC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANGIOGENESIS; ATHEROGENESIS; BIOMECHANICS; CAVEOLA; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL MOTILITY; CELL POLARITY; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; LIPID COMPOSITION; LIPID MEMBRANE; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SYSTEMATIC REVIEW; VASCULAR ENDOTHELIUM;

ANIMALS; BIOMECHANICS; CELL PHYSIOLOGY; CYTOSKELETON; HUMANS; INTEGRINS; LIPOPROTEINS, LDL; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL;

EID: 34547880426     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2007.1686     Document Type: Review

References (146)

1. Anderson RGW and Jacobson K. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296: 1821-1825, 2002.
2. Auge N, Andrieu N, Negre-Salvayre A, Thiers JC, Levade T, and Salvayre R. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J Biol Chem 271: 19251-19255, 1996.
3. Auge N, Maupas-Schwalm F, Elbaz M, Thiers JC, Waysbort A, Itohara S, Krell HW, Salvayre R, and Negre-Salvayre A. Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation 110: 571-578, 2004.
4. Babiychuk EB and Draeger A. Biochemical characterization of detergent-resistant membranes: A systematic approach. Biochem J 397: 407-416, 2006.
5. Berliner JA, Subbanagounder G, Leitinger N, Watson AD, and Vora D. Evidence for a role of phospholipid oxidation products in atherogenesis. Trends Cardiovasc Med 11: 142-147, 2001.
6. Biwa T, Sakai M, Matsumura T, Kobori S, Kaneko K, Miyazaki A, Hakamata H, Horiuchi S, and Shichiri M. Sites of action of protein kinase c and phosphatidylinositol 3-kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation. J Biol Chem 275: 5810-5816, 2000.
7. Blair A, Shaul PW, Yuhanna IS, Conrad PA, and Smart EJ. Oxidized low-density lipoprotein displaces endothelial nitric-oxide synthase from plasmalemmal caveolae and impairs eNOs activation. J Biol Chem 274: 32512-32519, 1999.
8. Bollinger CR, Teichgraber V, and Gulbins E. Ceramide-enriched membrane domains. Biochim Biophys Acta 1746: 284-294, 2005.
9. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, and Miller YI. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol 26: 1169-1176, 2006.
10. Breitschopf K, Zeiher AM, and Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an akt-dependent mechanism. FEBS Lett 493: 21-25, 2001.
11. Brown AD and London E. Structure and function of sphingolipid-and cholesterol-rich membrane rafts. J Biol Chem 275: 17221-17224, 2000.
12. Brown AJ, Dean RT, and Jessup W. Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. J Lipid Res 37: 320-335, 1996.
13. Brown DA and Rose JK. Sorting of gpi-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68: 533-544, 1992.
14. Byfield F, Aranda-Aspinoza H, Romanenko VG, Rothblat GH, and Levitan I. Cholesterol depletion increases membrane stiffness of aortic endothelial cells. Biophys J 87: 3336-3343, 2004.
15. Byfield FJ, Hoffman BD, Romanenko VG, Fang Y, Crocker JC, and Levitan I. Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. Acta Physiologica 187: 285-294, 2006.
16. Byfield FJ, Tikku S, Rothblat GH, Gooch KJ, and Levitan 1. OxLDL increases endothelial stiffness, force generation and network formation. J Lipid Res 47: 715-723, 2006.
17. Caroni P. New embo members' review: Actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts. EMBO J 20: 4332-4336, 2001.
18. Cazzolato G, Avogaro P, and Bittolo-Bon G. Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radic Biol Med Free Radic Biol Med 11: 247-253, 1991.
19. Chang WJ, Rothberg KG, Kamen BA, and Anderson RG. Low-ering the cholesterol content of ma104 cells inhibits receptor-mediated transport of folate. J Cell Biol 118: 63-69, 1992
20. Chen F, Eriksson P, Kimura T, Herzfeld I, and Valen G. Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque. Coron Artery Dis 16: 191-197, 2005.
21. Christian AE, Haynes MP, Phillips MC, and Rothblat GH. Use of cyclodextrins for manipulating cellular cholesterol content. J Lipid Res 38: 2264-2272, 1997.
22. Damiani E, Sugiyama T, Shimamura K, Greci L, and Matsuda Y. Altered expression of (alpha)-actin, smooth muscle myosin heavy chain-1 and calponin in cultured smooth muscle cells by oxidized low density lipoproteins. FEBS Lett 425: 123-125, 1998.
23. Darblade B, Caillaud D, Poirot M, Fouque M, Thiers JC, Rami J, Bayard F, and Arnal JF. Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta. Cardiovasc Res 50: 566-676, 2001.
24. Deigner HP, Claus R, Bonaterra GA, Gehrke C, Bibak N, Blaess M, Cantz M, Metz J, and Kinscherf R. Ceramide induces asmase expression: Implications for oxldl-induced apoptosis. FASEB J 15: 807-814, 2001.
25. Del Pozo MA. Integrin signaling and lipid rafts. Cell Cycle 3: 725-728, 2004.
26. Del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, and Schwartz MA. Integrins regulate RAC targeting by internalization of membrane domains. Science 303: 839-842, 2004.
27. Diaz MN, Frei B, Vita JA, and Keaney JFJ. Antioxidants and atherosclerotic heart disease. N Engl J Med 337: 408-416, 1997.
28. Doherty DE, Downey GP, Schwab B 3rd, Elson E, and Worthen GS. Lipolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and cd18-dependent adherence. J Immunol 153: 241-255, 1994.
29. Edidin M. Membrane cholesterol, protein phosphorylation and lipid rafts. Science's STKE 67 PE1, 2001.
30. Edidin M. The state of lipid rafts: From model membranes to cells. Ann Rev Biophys Biomol Struct 32; 257-283, 2003.
31. Erzurum SC, Kus ML, Bohse C, Elson EL, and Worthen GS. Mechanical properties of h160 cells: Role of stimulation and differentiation in retention in capillary-sized pores., Am J Respir Cell Mol Biol 5: 230-241, 1991.
32. Escargueil-Blanc I, Andrieu-Abadie N, Caspar-Bauguil S, Brossmer R, Levade T, Negre-Salvayre A, and Salvayre R. Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ecv-304 endothelial cells. J Biol Chem 273: 27389-27395, 1998.
33. Essler M, Retzer M, Bauer M, Heemskerk JW, Aepfelbacher M, and Siess W. Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of rho/rho kinase and inhibition of myosin light chain phosphatase. J Biol Chem 274: 30361-30364, 1999.
34. Evans E, and Needham D. Physical properties of surfactant bilayer membranes: Thermal transition, elasticity, rigidity, cohesion and colloidal interactions. J Physical Chem 91: 4219-4228, 1987.
35. Fessler MB, Arndt PG, Frasch SC, Lieber JG, Johnson CA, Murphy RC, Nick JA, Bratton DL, Malcolm KC, and Worthen GS. Lipid rafts regulate lipopolysaccharide-induced activation of cdc42 and inflammatory functions of the human neutrophil. J Biol Chem 279: 39989-39998, 2004.
36. Fessler MB, Malcolm KC, Duncan MW, and Worthen GS. A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. J Biol Chem 277: 31291-31302, 2002.
37. Galle J, Mameghani A, Bolz SS, Gambaryan S, Gorg M, Quaschning T, Raff U, Barfh H, Seibold S, Wanner C, and Pohl U. Oxidized LDL and its compound lysophosphatidylcholine potentiate angii-induced vasoconstriction by stimulation of RhoA. J Am Soc Nephrol 14: 1471-1479, 2003.
38. Galvez BG, Matias-Roman S, Yanez-Mo M, Vicente-Manzanares M, Sanchez-Madrid F, and Arroyo AG. Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells. Mol Biol Cell 15: 678-687, 2004.
39. Gaus K, Gratton E, Kable EP, Jones AS, Gelissen I, Kritharides L, and Jessup W. Visualizing lipid structure and raft domains in living cells with two-photon microscopy, Proc Natl Acad Sci USA 100: 15554-15559, 2003.
40. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, and Jessup W. Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J 18: 574-576, 2004.
41. Gaus K, Rodriguez M, Ruberu KR, Gelissen I, Sloane TM, Kritharides L, and Jessup W. Domain-specific lipid distribution in macrophage plasma membranes. J Lipid Res 46: 1526-1538, 2005.
42. Gidwani A, Holowka D, and Baird B. Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from rb1-2h3 mast cells. Biochemistry 40: 12422-12429, 2001.
43. Golub T and Caroni P. PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility. J Cell Biol 169: 151-165, 2005.
44. Gomez-Mouton C, Abad JL, Mira E, Lacalle RA, Gallardo E, Jimenez-Baranda S, Illa I, Bernad A, Manes S, and Martinez AC. From the cover: Segregation of leading-edge and uropod components into specific lipid rafts during t cell polarization. Proc Natl Acad Sci USA 98: 9642-9647, 2001.
45. Grandl M, Bared SM, Liebisch G, Werner T, Barlage S, and Schmitz G. E-LDL and ox-LDL differentially regulate ceramide and cholesterol raft microdomains in human macrophages. Cytometry A 69: 189-191, 2006.
46. Hall A. Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
47. Harada-Shiba M, Kinoshita M, Kamido H, and Shimokado K. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J Biol Chem 273: 9681-9687, 1998.
48. Harder T and Engelhardt KR. Membrane domains in lymphocytes - from lipid rafts to protein scaffolds. Traffic 5: 265-275, 2004.
49. Harder T, Kellner R, Parton RG, and Gruenberg J. Specific release of membrane-bound annexin II and cortical cytoskeleton elements by sequestration of membrane cholesterol. Mol Biol Cell 8: 533-545, 1997.
50. Haynes MP, Phillips MC, and Rothblat GH. Efflux of cholesterol from different cellular pools. Biochemistry 39: 4508-4517, 2000.
51. Heerklotz H. Triton promotes domain formation in lipid raft mixtures. Biophys J 83: 2693-2701, 2002.
52. Hodis HN, Kramsch DM, Avogaro P, Bittolo-Bon G, Cazzolato G, Hwang J, Peterson H, and Sevanian A. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL). J Lipid Res 35: 669-677, 1994.
53. Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, and Mehta D. Suppression of rhoa activity by focal adhesion kinase-induced activation of p190Rhogap: Role in regulation of endothelial permeability. J Biol Chem 281: 2296-2305, 2006.
54. Holvoet P, Mertens A, Verhamme P, Bogaerts K, Beyens G, Verhaeghe R, Collen D, Muls E, and Van de Werf F. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol 21: 844-848, 2001.
55. Holvoet P, Theilmeier G, Shivalkar B, Flameng W, and Collen D. LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs. Arterioscler Thromb Vasc Biol, 18: 415-422, 1998.
56. Holvoet P, Vanhaecke J, Janssens S, Van de Werf F, and Collen D. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation 98: 1487-1494, 1998.
57. Horton JD, Goldstein JL, and Brown MS. Srebps: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131, 2002.
58. Hundal RS, Gomez-Munoz A, Kong JY, Salh BS, Marotta A, Duronio V, and Steinbrecher UP. Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase b activation and bcl-xl levels. J Biol Chem 278: 24399-24408, 2003.
59. Izgi C, Cevik C, Ozkan M, Auge N, Maupas-Schwalm F, Thiers JC, Waysbort A, Salvayre R, Negre-Salvayre A, Elbaz M, Krell HW, and Itohara S, Letter regarding article by Auge et al, "role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ ceramide pathway and smooth muscle cell proliferation" * response. Circulation 111: e38-39, 2005.
60. Janes PW, Ley SC, and Magee AI. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 147: 447-461, 1999.
61. Jialal I and Chait A. Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: Inhibition of cholesterol esterification by oxidatively modified low density lipoprotein. J Lipid Res 30: 1561-1568, 1989.
62. Kincer JF, Uittenbogaard A, Dressman J, Guerin TM, Febbraio M, Guo L, and Smart EJ. Hypercholesterolemia promotes a cd36-dependent and endothelial nitric-oxide synfhase-mediated vascular dysfunction. J Biol Chem 23525-23533, 2002.
63. Kinscherf R, Claus R, Deigner HP, Nauen O, Gehrke C, Hermetter A, Ruwurm S, Daniel V, Hack V, and Metz J. Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin-ceramide pathway in human macrophages. FEBS Lett 405: 55-59, 1997.
64. Kitatani K, Nemoto M, Akiba S, and Sato T. Stimulation by de novo-synthesized ceramide of phospholipase a2-dependent cholesterol esterification promoted by the uptake of oxidized low-density lipoprotein in macrophages. Cell Signal 14: 695-701, 2002.
65. Kole TP, Tseng Y, Huang L, Katz JL, and Wirtz D. Rho kinase regulates the intracellular micromechanical response of adherent cells to Rho activation. Mol Biol Cell 15: 3475-3484, 2004.
66. Kozma R, Ahmed S, Best A, and Lim L. The ras-related protein cdc42hs and bradykinin promote formation of peripheral actin microspikes and filopodia in swiss 3T3 fibroblasts. Mol Cell Biol 15: 1942-1952, 1995.
67. Kumanogoh H, Miyata S, Sokawa Y, and Maekawa S. Biochemical and morphological analysis on the localization of Rac1 in neurons. Neurosci Res 39: 189-196, 2001.
68. Kwik J, Boyle S, Fooksman D, Margolis L, Sheetz MP, and Edidin M. Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin. Proc Natl Acad Sci USA 100: 13964-13969, 2003.
69. Larbi A, Douziech N, Khalil A, Dupuis G, Gherairi S, Guerard KP, and Fulop T Jr. Effects of methyl-beta-cyclodextrin on t lymphocytes lipid rafts with aging. Exp Gerontol 39: 551-558, 2004.
70. Li S, Guan JL, and Chien S. Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng 7: 105-150, 2005.
71. Lichtenberg D, Goni FM, and Heerklotz H. Detergent-resistant membranes should not be identified with membrane rafts. Trends Biochem Sci 30: 430-436, 2005.
72. Loidl A, Sevcsik E, Riesenhuber G, Deigner HP, and Hermetter A. Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells. J Biol Chem 278: 32921-32928, 2003.
73. Malorni W, Straface E, Genova GD, Fattorossi A, Rivabene R, Camponeschi B, Masella R, and Viora M. Oxidized low-density lipoproteins affect natural killer cell activity by impairing cytoskeleton function and altering the cytokine network. Exp Cell Res 236: 436, 1997.
74. Manes S, Ana Lacalle R, Gomez-Mouton C, and Martinez AC. From rafts to crafts: Membrane asymmetry in moving cells. Trends Immunol 24: 320-326, 2003.
75. Manes S, Mira E, Gomez-Mouton C, Lacalle RA, Keller P, Labrador JP, and Martinez AC. Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J 18: 6211-6220, 1999.
76. Massaeli H, Hurtado C, Austria JA, and Pierce GN. Oxidized low-density lipoprotein induces cytoskeletal disorganization in smooth muscle cells. Am J Physiol Heart Circ Physiol 277: H2017-2025, 1999.
77. Meiri KF. Lipid rafts and regulation of the cytoskeleton during t cell activation. Philos Trans R Soc Land B Biol Sci. 360: 1663-1672, 2005.
78. Miceli MC, Moran M, Chung CD, Patel VP, Low T, and Zinnanti W. Co-stimulation and counter-stimulation: Lipid raft clustering controls tcr signaling and functional outcomes., Semin Immunol 13: 115-128, 2001.
79. Michaely PA, Mineo C, Ying YS, and Anderson RG. Polarized distribution of endogenous Rac1 and RhoA at the cell surface. J Biol Chem 274: 21430-21436, 1999.
80. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, and Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via tlr4/md-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem 278: 1561-1568, 2003.
81. Miller YI, Worrall DS, Funk CD, Feramisco JR, and Witztum JL. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: Role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell 14: 4196-4206, 2003.
82. Mine S, Tabata T, Wada Y, Fujisaki T, Iida T, Noguchi N, Niki E, Kodama T, and Tanaka Y. Oxidized low density lipoprotein-induced lfa-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase c pathway. Atherosclerosis 160: 281-288, 2002.
83. Muller K, Dulku S, Hardwick SJ, Skepper JN, and Mitchinson MJ. Changes in vimentin in human macrophages during apoptosis induced by oxidised low density lipoprotein. Atherosclerosis 156: 133-144, 2001.
84. Munro S. Lipid rafts: Elusive or illusive? Cell 115: 377-88, 2003.
85. Nakai Y and Kamiguchi H. Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner. J Cell Biol 159: 1097-1108, 2002.
86. Nebl T, Pestonjamasp KN, Leszyk JD, Crowley JL, Oh SW, and Luna EJ. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem 277: 43399-43409, 2002.
87. Needham D and Nunn RS. Elastic deformation and failure of lipid bilayer membranes containing cholesterol. Biophys J 58: 997-1009, 1990.
88. Nihei SI, Yamashita K, Tasaki H, Ozumi K, and Nakashima Y. Oxidized low-density lipoprotein-induced apoptosis is attenuated by insulin-activated phosphatidylinositol 3-kinase/akt through p38 mitogen-activated protein kinase. Clin Exper Pharm Physiol.32: 224-229, 2005.
89. Nobes CD and Hall A. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 7: 53-62, 1995.
90. Ottico E, Prinetti A, Prioni S, Giannotta C, Basso L, Chigorno V, and Sonnino S, Dynamics of membrane lipid domains in neuronal cells differentiated in culture. J Lipid Res 44: 2142-2151, 2003.
91. Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, and Gundersen GG. Localized stabilization of microtubules by integrin-and fak-facilitated rho signaling. Science 303 836-839, 2004.
92. Parton RG. Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae. J Histochem Cytochem 42:155-166, 1994.
93. Pike L and Casey L. Localization and turnover of phosphatidyl-inositol 4,5-bisphospate in caveolin-enriched membrane domains. J Biol Chem 271: 26453-26456, 1996.
94. Pike LJ. Rafts defined: A report on the keystone symposium on lipid rafts and cell function. J Lipid Res 47: 1597-1598, 2006.
95. Pike LJ and Miller JM. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem 273: 22298-22304, 1998.
96. Pourati J, Maniotis A, Spiegel D, Schaffer JL, Butler JP, Fredberg JJ, Ingber DE, Stamenovic D, and Wang N. Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells? Am J Physiol Cell 274: C1283-1289, 1998.
97. Rao R, Logan B, Forrest K, Roszman TL, and Goebel J. Lipid rafts in cytokine signaling. Cytokine Growth Factor Rev 15: 103-110, 2004.
98. Retzer M, Siess W, and Essler M. Mildly oxidised low density lipoprotein induces platelet shape change via rho-kinase-dependent phosphorylation of myosin light chain and moesin. FEBS Lett 466: 70-74, 2000.
99. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, and Hall A. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 7: 401-410, 1992.
100. Roma P, Catapano AL, Bertulli SM, Varesi L, Fumagalli R, and Bernini F. Oxidized LDL increase free cholesterol and fail to stimulate cholesterol esterification in murine macrophages. Biochem Biophys Res Comm 171: 123-131, 1990.
101. Romberg KG, Ying YS, Kamen BA, and Anderson RG. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J Cell Biol 111: 2931-2938, 1990.
102. Rotsch C and Radmacher M. Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: An atomic force microscopy study. Biophys J 78: 520-535, 2000.
103. Rouquette-Jazdanian AK, Pelassy C, Breittmayer JP, and Aussel C. Revaluation of the role of cholesterol in stabilizing rafts implicated in t cell receptor signaling. Cell Signal 18: 105-122, 2006.
104. Sato M, Theret DP, Wheeler LT, Ohshima N, and Nerem RM. Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties. J Biomech Eng 112: 263-268, 1990.
105. Schutz GJ, Kada G, Pastushenko VP, and Schindler H. Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy. EMBO J 19: 892-901, 2000.
106. Seibold S, Schurle D, Heinloth A, Wolf G, Wagner M, and Galle J. Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27kip1 expression: Role of RhoA. J Am Soc Nephrol 15: 3026-3034, 2004.
107. Shogomori H and Brown DA. Use of detergents to study membrane rafts: The good, the bad, and the ugly. Biol Chem 384: 1259-1263, 2003.
108. Sieminski AL, Hebbel RP, and Gooch KJ. Improved microvascular network in vitro by human blood outgrowth endothelial cells relative to vessel-derived endothelial cells. Tissue Eng 11: 1332-1345, 2005.
109. Sieminski AL, Hebbel RP, and Gooch KJ. The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro. Exp Cell Res 297: 574-584, 2004.
110. Simons K and Ikonen E. Functional rafts in cell membranes. Nature 387: 569-572, 1997.
111. Simons K and Toomre D. Lipid rafts and signal transduction. Nature Rev Mol Cell Biol 1: 31-39, 2000.
112. Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T, and Lisanti MP. Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol 19: 7289-7304, 1999.
113. Smart EJ, Ying Y, Mineo C, and Anderson RGW. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci USA 92: 10104-10108, 1995.
114. Smart EJ, Ying YS, Conrad PA, and Anderson RG. Caveolin moves from caveolae to the golgi apparatus in response to cholesterol oxidation. J Cell Biol 127: 1185-1197, 1994.
115. Sowa G, Pypaert M, and Sessa WC. Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci USA 98: 14072-14077, 2001.
116. Sprenger RR, Speijer D, Back JW, De Koster CG, Pannekoek H, and Horrevoets AJ. Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry. Electrophoresis 25: 156-172, 2004.
117. Stahlhut M and van Deurs B. Identification of filamin as a novel ligand for caveolin-1: Evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol Biol Cell 11: 325-337, 2000.
118. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, and Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320: 915-924, 1989.
119. Steinbrecher UP, Gomez-Munoz A, and Duronio V. Acid sphingomyelinase in macrophage apoptosis. Curr Opin Lipidol 15: 531-537, 2004.
120. Subbaiah PV, Billington SJ, Jost BH, Songer JG, and Lange Y. Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts. J Lipid Res 44: 1574-1580, 2003.
121. Sun M, Northup N, Marga F, Byfield FJ, Levitan I, and Forgacs G., Cellular cholesterol effects on membrane-cytoskeleton adhesion. J Cell Sci 2007 (in press).
122. Swamy MJ, Ciani L, Ge M, Smith AK, Holowka D, Baird B, and Freed. H. Coexisting domains in the plasma membranes of live cells characterized by spin-label esr spectroscopy. Biophys J 90: 4452-4465, 2006.
123. Toshima SI, Hasegawa A, Kurabayashi M, Itabe H, Takano T, Sugano J, Shimamura K, Kimura J, Michishita I, Suzuki T, and Nagai R. Circulating oxidized low density lipoprotein levels: a biochemical risk marker for coronary heart disease. Arterioscler Thromb Vasc Biol 20: 2243-2247, 2000.
124. Uittenbogaard A, Shaul PW, Yuhanna IS, Blair A, and Smart EJ. High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae. J Biol Chem 275: 11278-11283, 2000.
125. van den Eijnden MMED, van Noort JT, Hollaar L, van der Laarse A, and Bertina RM. Cholesterol or triglyceride loading of human monocyte-derived macrophages by incubation with modified lipoproteins does not induce tissue factor expression. Arterioscler Thromb Vasc Biol 19: 384-392, 1999.
126. van Rheenen J, Achame EM, Janssen H, Calafat J, and Jalink K. PIP2 signaling in lipid domains: A critical re-evaluation. EMBO J 24: 1664-1673, 2005.
127. van Rheenen J and Jalink K. Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: Regulation at a global but not at a micrometer scale. Mol Biol Cell 13: 3257-3267, 2002.
128. van Tits LJ, van Himbergen TM, Lemmers HL, de Graaf J, and Stalenhoef AF. Proportion of oxidized ldl relative to plasma apolipoprotein b does not change during statin therapy in patients with heterozygous familial hypercholesterolemia. Atherosclerosis 185: 307-312, 2006.
129. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN, Wrenn SP, and Narula J. Atherosclerotic plaque progression and vulnerability to rupture: Angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 25: 2054-2061, 2005.
130. Walton KA, Cole AL, Yeh M, Subbanagounder G, Krutzik SR, Modlin RL, Lucas RM, Nakai J, Smart EJ, Vora DK, and Berliner JA. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol 23: 1197-1203, 2003.
131. Walton KA, Gugiu BG, Thomas M, Basseri RJ, Eliav DR, Salomon RG, and Berliner JA. A role for neutral sphingomyelinase activation in the inhibition of lps action by phospholipid. J Lipid Res 47: 1967-1974, 2006.
132. Wang JH and Lin JS. Cell traction force and measurement methods. Biomech Model Mechanobiol Jan 3; (Epub ahead of print) (2007).
133. Wang N, Tolic-Norrelykke IM, Chen J, Mijailovich SM, Butler JP, Fredberg JJ, and Stamenovic D. Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. Am J Physiol Cell Physiol 282: C606-616, 2002.
134. Watson AD, Leitinger N, Navab M, Faull KF, Horkko S, Witztum JL, Palinski W, Schwenke D, Salomon RG, Sha W, Subbanagounder G, Fogelman AM, and Berliner JA. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endomelial interactions and evidence for their presence in vivo. J Biol Chem 272: 13597-13607, 1997.
135. Wu HW, Kuhn T, and Moy VT. Mechanical properties of 1929 cells measured by atomic force microscopy: Effects of anticytoskeletal drugs and membrane crosslinking. Scanning 20: 389-397, 1998.
136. Wulfing C, Purtic B, Klem J, and Schatzle JD. Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing. Proc Natl Acad Sci USA 100: 7767-7772, 2003.
137. Wustner D. Plasma membrane sterol distribution resembles the surface topography of living cells. Mol Biol Cell 18: 211-228, 2007.
138. Yancey PG and Jerome WG. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. J Lipid Res 39:1349-1361, 1998.
139. Yancey PG, Rodrigueza WV, Kilsdonk EP, Stoudt GW, Johnson WJ, Phillips MC, and Rothblat GH. Cellular cholesterol efflux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efflux. J Biol Chem 271: 16026-16034, 1996.
140. Yang J, Yu Y, Sun S, and Duerksen-Hughes PJ. Ceramide and other sphingolipids in cellular responses. Cell Biochem Biophys 40: 323-350, 2004.
141. Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JYJ, and Berliner JA. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res 95: 780-788, 2004.
142. Yin HL and Janmey PA. Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 65: 761-789, 2003.
143. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, and Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 84: 1086-1095, 1989.
144. Zerbinatti CV and Gore RW. Uptake of modified low-density lipoproteins alters actin distribution and locomotor forces in macrophages. Am J Physiol Cell Physiol 284: C555-561, 2003.
145. Zhao B, Ehringer WD, Dierichs R, and Miller FN. Oxidized low-density lipoprotein increases endothelial intracellular calcium and alters cytoskeletal f-actin distribution. Eur J Clin Invest 27: 48-54, 1997.
146. Zidovetzki R and Levitan I. Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. BBA Membranes 1768: 1311-1324, 2007.