Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA

Journal of the American Society of Nephrology

Volumn 14, Issue 6, 2003, Pages 1471-1479

  Galle, Jan ^a,d   Mameghani, Alexander ^a   Bolz, Steffen Sebastian ^b   Gambaryan, Stepan ^a   Görg, Maria ^a   Quaschning, Thomas ^a   Raff, Ulrike ^a   Barth, Holger ^c   Seibold, Stefan ^a   Wanner, Christoph ^a   Pohl, Ulrich ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CALCIUM ANTAGONIST; FELODIPINE; LOSARTAN; LYSOPHOSPHATIDYLCHOLINE; OXIDIZED LOW DENSITY LIPOPROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSFERASE;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL TONE; CELL MEMBRANE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT; SMOOTH MUSCLE CONTRACTILITY; VASOCONSTRICTION; VASOSPASM; WESTERN BLOTTING;

EID: 0037498501     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000067412.18899.9B     Document Type: Article

References (38)

1. Verbeuren T, Jordaens F, Zonnekeyn L, Van Hove C, Coehe M, Herman A: 1. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ Res 58: 552-564, 1986
2. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA: Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol 23: 844-850, 1994
3. Drexler H, Zeiher AM: Endothelial function in human coronary arteries in vivo - Focus on hypercholesterolemia. Hypertension 18: 90-99, 1991
4. Liu JJ, Chen JR, Wiley J, Johnston CC, Buxton BF: Inhibition by a stable factor derived from neutrophils of endothelium-dependent relaxation in rat aorta. Am J Physiol 265: H1454-H1459, 1993
5. Heistad DD, Armstrong ML, Marcus ML, Piegors DJ, Mark AL: Augmented responses to vasoconstrictor stimuli in hypercholes-terolemic and atherosclerotic monkeys. Circ Res 54: 711-718, 1984
6. Rosendorff C, Hoffman JIE, Verrier ED, Rouleau J, Boerboom LE: Cholesterol potentiates the coronary artery response to norepinephrine in anesthetized and conscious dogs. Circ Res 48: 320-329, 1981
7. Shimokawa H, Tomoike H, Nabeyama S, Yamamoto H, Ishii Y, Tanaka K, Nakamura M: Coronary artery spasm induced in miniature swine: Angiographic evidence and relation to coronary atherosclerosis. Am Heart J 110: 300-310, 1985
8. Galle J, Busse R, Bassenge E: Hypercholesterolemia and athero-sclerosis change vascular reactivity in rabbits by different mechanisms. Arterioscler Thromb 11: 1712-1718, 1991
9. Pohl U, Heydari N, Galle J: Effects of LDL on intracellular free calcium and nitric oxide-dependent cGMP formation in porcine endothelial cells. Atherosclerosis 117: 169-178, 1995
10. Sachinidis A, Locher R, Mengden T, Steiner A, Vetter W: Vasoconstriction: A novel activity for low density lipoprotein. Biochem Biophys Res Commun 163: 315-320, 1989
11. Sachinidis A, Locher R, Mengden T, Vetter W: Low-density lipoprotein elevates intrecellular Calcium and pH in vascular smooth muscle cells and fibroblasts without mediation of LDL receptor. Biochem Biophys Res Commun 167: 353-359, 1990
12. Galle J, Bassenge E, Busse R: Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circ Res 66: 1287-1293, 1990
13. Somlyo AP, Somlyo AV: Signal transduction and regulation in smooth muscle [published erratum appears in Nature 372: 812, 1994]. Nature 372: 231-236, 1994
14. 2+ via a Rho- and Rho-kinase-dependent mechanism. Circulation 102: 2402-2410, 2000
15. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A: Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation 101: 1319-1323, 2000
16. Batchelor TJP, Sadaba JR, Ishola A, Pacaud P, Munsch CM, Beech DJ: Rho-kinase inhibitors prevent agonist-induced vasospasm in human internal mammary artery. Br J Pharmacol 132: 302-308, 2001
17. Chrissobolis S, Sobey CG: Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension - Comparison with protein kinase C. Circ Res 88: 774-779, 2001
18. Kandabashi T, Shimokawa H, Mukai Y, Matoba T, Kunihiro I, Morikawa K, Ito M, Takahashi S, Kaibuchi K, Takeshita A: Involvement of Rho-kinase in agonists- induced contractions of arteriosclerotic human arteries. Arterioscler Thromb Vasc Biol 22: 243-248, 2002
19. Parthasarathy S, Steinbrecher U, Barnett J, Witztum JL, Steinberg D: Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proc Natl Acad Sci USA 82: 3000-3004, 1985
20. Galle J, Schneider R, Winner B, Lehmann-Bodem C, Schinzel R, Münch G, Conzelmann E, Wanner C: Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stress. Atherosclerosis 138: 65-77, 1998
21. Potter DD, Sobey CG, Tompkins PK, Rossen JD, Heistad DD: Evidence that macrophages in atherosclerotic lesions contain angiotensin II. Circulation 98: 800-807, 1998
22. Schieffer B, Schieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, Kaartinen M, Nussberger J, Harringer W, Drexler H: Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques - Potential implications for inflammation and plaque instability. Circulation 101: 1372-1378, 2000
23. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S: Calcium sensitization of smooth muscle mediated by a Rhoassociated protein kinase in hypertension [see comments]. Nature 389: 990-994, 1997
24. Barth H, Hofmann F, Olenik C, Just I, Aktories K: The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun 66: 1364-1369, 1998
25. Gong MC, Fujihara H, Somlyo AV, Somlyo AP: Translocation of rhoA associated with Ca2+ sensitization of smooth muscle. J Biol Chem 272: 10704-10709, 1997
26. Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D: Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism. Arteriosclerosis 7: 135-143, 1987
27. Aktories K, Hall A: Botulinum ADP-ribosyltransferase C3: A new tool to study low molecular weight GTP-binding proteins. Trends Pharmacol Sci 10: 415-418, 1989
28. Barth H, Roebling R, Fritz M, Aktories K: The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components. J Biol Chem 277: 5074-5081, 2002
29. Barth H, Blocker D, Behlke J, Bergsma Schutter W, Brisson A, Benz R, Aktories K: Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification. J Biol Chem 275: 18704-18711, 2000
30. Flavahan NA: Atherosclerosis or lipoprotein-induced endothelial dysfunction - Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation 85: 1927-1938, 1992
31. Jessup W: Oxidized lipoproteins and nitric oxide. Curr Opin Lipidol 7: 274-280, 1996
32. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Bräsen JH, Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Böhm M, Meinertz T, Münzel T: Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis - Evidence for involvement of the renin-angiotensin system. Circulation 99: 2027-2033, 1999
33. Galle J, Bauersachs J, Bassenge E, Busse R: Arterial size determines the enhancement of contractile responses after suppression of endothelium-derived relaxing factor formation. Pflugers Arch 422: 564-569, 1993
34. Somlyo AV, Somlyo AP: Intracellular signaling in vascular smooth muscle. Adv Exp Med Biol 346: 31-38, 1993
35. Matrougui K, Tanko LB, Loufrani L, Gorny D, Levy BI, Tedgui A, Henrion D: Involvement of rho-kinase and the actin filament network in angiotensin II-Induced contraction and extracellular signal-regulated kinase activity in intact rat mesenteric resistance arteries. Arterioscler Thromb Vasc Biol 21: 1288-1293, 2001
36. Aoki H, Izumo S, Sadoshima J: Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 82: 666-676, 1998
37. Essler M, Retzer M, Bauer M, Heemskerk JW, Aepfelbacher M, Siess W: Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase. J Biol Chem 274: 30361-30364, 1999
38. Esterbauer H, Gebicki J, Puhl H, Jürgens G: The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad Biol Med 13: 341-390, 1992