Oxidized low-density lipoprotein induces cytoskeletal disorganization in smooth muscle cells

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 5 46-5, 1999, Pages

  Massaeli, Hamid ^a   Hurtado, Cecilia ^a   Austria, J Alejandro ^a   Pierce, Grant N ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Actin; Atherosclerosis; Contractile proteins; Cytoskeleton; Myosin; Smooth muscle

Indexed keywords

ACTIN; LOW DENSITY LIPOPROTEIN; MYOSIN;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CELL DAMAGE; CYTOSKELETON; LIPID PEROXIDATION; MYOFILAMENT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; RABBIT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0032756563     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.5.h2017     Document Type: Article

References (32)

1. Aikawa, M., E. Rabkin, S. J. Voglic, H. Shing, R. Nagai, F. J. Schoen, and P. Libby. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ. Res. 83: 1015-1026, 1998.
2. Alomar, Y., S. A. Negre, T. Levade, P. Valdiguie, and R. Salvayre. Oxidized HDL are much less cytotoxic to lymphoblastoid cells than oxidized LDL. Biochim. Biophys. Acta 1128: 163-166, 1992.
3. Björkerud, S., K. Gustavsson, and M. Hasselgren. In vitro cultivation of rabbit aortic media and the development of the cultures in relation to cellular heterogeneity. Acta Pathol. Microbiol. Scand. Sect. A Pathol. 92: 113-124, 1984.
4. Boulanger, C. M., F. C. Tanner, M. L. Bea, A. W. Hahn, A. Werner, and T. F. Luscher. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ. Res. 70: 1191-1197, 1992.
5. Campbell, G. R., J. H. Campbell, J. A. Manderson, S. Horrigan, and R. E. Rennick. Arterial smooth muscle. A multifunctional mesenchymal cell. Arch. Pathol. Lab. Med. 112: 977-986, 1988.
6. Campbell, J. H., and G. R. Campbell. Biology of the vessel wall and atherosclerosis. Clin. Exp. Hypertens. 11: 901-913, 1989.
7. Campbell, J. H., O. Kocher, O. Skalli, G. Gabbiani, and G. R. Campbell. Cytodifferentiation and expression of alpha-smooth muscle actin mRNA and protein during primary culture of aortic smooth muscle cells. Correlation with cell density and proliferative state. Arteriosclerosis 9: 633-643, 1989.
8. Chen, C. H., J. Cartwright, Jr., Z. Li, S. Lou, H. H. Nguyen, A. M. Gotto, Jr., and P. D. Henry. Inhibitory effects of hypercholesterolemia and ox-LDL on angiogenesis-like endothelial growth in rabbit aortic explants. Essential role of basic fibroblast growth factor. Arterioscler. Thromb. Vasc. Biol. 17: 1303-1312, 1997.
9. Colangelo, S., B. L. Langille, G. Steiner, and A. I. Gotlieb. Alterations in endothelial F-actin microfilaments in rabbit aorta in hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 18: 52-56, 1998.
10. Fogelman, A. M., I. Shechter, J. Seager, M. Hokom, J. S. Child, and P. A. Edwards. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc. Natl. Acad. Sci. USA 77: 2214-2218, 1980.
11. Grünwald, J., and C. C. Haudenschild. Intirnal injury in vivo activates vascular smooth muscle cell migration and explant outgrowth in vitro. Arteriosclerosis 4: 183-188, 1984.
12. Halliwell, B., and S. Chirico. Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr. 57: 715S-724S, 1993.
13. Huot, J., F. Houle, F. Marceau, and J. Landry. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ. Res. 80: 383-392, 1997.
14. Kocher, O., F. Gabbiani, G. Gabbiani, M. A. Reidy, M. S. Cokay, H. Peters, and I. Huttner. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab. Invest. 65: 459-470, 1991.
15. Kocher, O., and G. Gabbiani. Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells. Hum. Pathol. 17: 875-880, 1986.
16. Kusuhara, M., A. Chait, A. Cader, and B. C. Berk. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler. Thromb. Vasc. Biol. 17: 141-148, 1997.
17. Libby, P., and K. V. O'Brien. Culture of quiescent arterial smooth muscle cells in a defined serum-free medium. J. Cell. Physiol. 115: 217-223, 1983.
18. Libby, P., and K. V. O'Brien. The role of protein breakdown in growth, quiescence, and starvation of vascular smooth muscle cells. J. Cell. Physiol. 118: 317-323, 1984.
19. Liu, K., H. Massaeli, and G. N. Pierce. The action of oxidized low density lipoprotein on calcium transients in isolated rabbit cardiomyocytes. J. Biol. Chem. 268: 4145-4151, 1993.
20. Liu, K. Z., T. G. Maddaford, B. Ramjiawan, M. J. Kutryk, and G. N. Pierce. Effects of cholesterol oxidase on cultured vascular smooth muscle cells. Mol. Cell. Biochem. 108: 39-48, 1991.
21. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and A. J. Randall. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
22. Massaeli, H., S. Sobrattee, and G. N. Pierce. The importance of lipid solubility in antioxidants and free radical generating systems for determining lipoprotein peroxidation. Free Radic. Biol. Med. 26: 1524-H1530, 1999.
23. Nikkari, S. T., T. Solakivi, T. Sisto, and O. Jaakkola. Antibodies to cytoskeletal proteins in sera of patients with angiographically assessed coronary artery disease. Atherosclerosis 98: 11-16, 1993.
24. Omodeo-Sale, F., S. Marchesini, P. H. Fishman, and B. Berra. A sensitive enzymatic assay for determination of cholesterol in lipid extracts. Anal. Biochem. 142: 347-350, 1984.
25. Palladini, G., G. Finardi, and G. Bellomo. Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. Exp. Cell Res. 223: 72-82, 1996.
26. Sevanian, A., and L. L. McLeod. Cholesterol autoxidation in phospholipid membrane bilayers. Lipids 22: 627-636, 1987.
27. Simon, B. C., L. D. Cunningham, and R. A. Cohen. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J. Clin. Invest. 86: 75-79, 1990.
28. Steinberg, D. Lipoproteins and the pathogenesis of atherosclerosis. Circulation 76: 508-514, 1987.
29. Steinberg, D. Oxidized low density lipoprotein-an extreme example of lipoprotein heterogeneity. Isr. J. Med. Sci. 32: 469-472, 1996.
30. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924, 1989.
31. Witztum, J. L. Role of oxidised low density lipoprotein in atherogenesis. Br. Heart J. 69: S12-S18, 1993.
32. Zhao, B., W. D. Ehringer, R. Dierichs, and F. N. Miller. Oxidized low-density lipoprotein increases endothelial intracellular calcium and alters cytoskeletal f-actin distribution. Eur. J. Clin. Invest. 27: 48-54, 1997.