Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression

Clinical and Experimental Immunology

Volumn 149, Issue 3, 2007, Pages 570-578

  Rodrigues Dos Santos Jr , R ^a   Sartori, A ^b   Deperon Bonato, V L ^a   Coelho Castelo, A A M ^a   Vilella, C A ^c   Zollner, R L ^c   Lopes Silva, C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cytokines; Diabetes; DNA vaccine; Heat shock protein (Hsp65)

Indexed keywords

DNA VACCINE; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL INFILTRATION; CELL TRANSPORT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; DNA VECTOR; DRUG EFFECT; FEMALE; IMMUNOMODULATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET CELL; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BACTERIAL; AUTOANTIGENS; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHAPERONINS; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; TUBERCULOSIS VACCINES; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, DNA;

EID: 34547875389     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03433.x     Document Type: Article

References (51)

1. Gurunathan S, Wu CY, Freidag BL, Seder RA. DNA vaccines: a key for inducing long-term cellular immunity. Curr Opin Immunol 2000 12 : 442 7.
2. Silva CL, Bonato VLD, Coelho Castelo AAM, Lima KM, Rodrigues JM Jr. Vacinas gênicas, capítulo 23. In : Mir L, ed. Genômica : Ciência da Vida, 2004 : 463 93.
3. Stevenson FK, Link CJ, Traynor A Jr., Yu H, Corr M. DNA vaccination against multiple myeloma. Semin Hematol 1999 36 (Suppl. 3 38 42.
4. Ulmer JB, Fu TM, Deck RR et al. Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA. J Virol 1998 72 : 5648 53.
5. Waisman A, Ruiz PJ, Hirschberg DL et al. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 1996 2 : 899 905.
6. Hassett DE, Zhang J, Slifka M, Whitton JL. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. J Virol 2000 74 : 2620 7.
7. Bonato VL, Lima VM, Tascon RE, Lowrie DB, Silva CL. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun 1998 66 : 169 75.
8. Silva CL, Bonato VL, Lima VM, Faccioli LH, Leao SC. Characterization of the memory/activated T cells that mediate the long-lived host response against tuberculosis after bacillus Calmette-Guerin or DNA vaccination. Immunology 1999 97 : 573 81.
9. Bonato VL, Goncalves ED, Soares EG et al. Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis. activation of CD8+ cells, interferon-gamma recovery and reduction of lung injury. Immunology 2004 113 : 130 8.
10. Lowrie DB, Tascon RE, Bonato VL et al. Therapy of tuberculosis in mice by DNA vaccination. Nature 1999 400 : 269 71.
11. Silva CL, Lowrie DB. Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis. Infect Immun 2000 68 : 3269 74.
12. Silva CL, Silva MF, Pietro RC, Lowrie DB. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect Immun 1996 64 : 2400 7.
13. Feige U, van Eden W. Infection, autoimmunity and autoimmune disease. Experientia 1996 77 : 359 73.
14. Afek A, George J, Gilburd B et al. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J Autoimmun 2000 14 : 115 21.
15. Keren P, George J, Shaish A et al. Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. Diabetes 2000 49 : 1064 9.
16. Danieli MG, Markovits D, Gabrielli A et al. Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein. Clin Immunol Immunopathol 1992 64 : 121 8.
17. Tanaka S, Kimura Y, Mitani A et al. Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis. J Immunol 1999 163 : 5560 5.
18. Thompson SJ, Francis JN, Siew LK et al. An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis. J Immunol 1998 160 : 4628 34.
19. van Eden W. Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immunol Rev 1991 121 : 5 28.
20. Bras A, Aguas AP. Diabetes-prone NOD mice are resistant to Mycobacterium avium and the infection prevents autoimmune disease. Immunology 1996 89 : 20 5.
21. Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 1991 88 : 3088 91.
22. Gupta MM, Raghunath D, Kher SK, Radhakrishnan AP. Human leucocyte antigen and insulin dependent diabetes mellitus. J Assoc Phys India 1991 39 : 540 3.
23. Kallmann BA, Lampeter EF, Hanifi-Moghaddam P, Hawa M, Leslie RD, Kolb H. Cytokine secretion patterns in twins discordant for Type I diabetes. Diabetologia 1999 42 : 1080 5.
24. Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996 85 : 291 7.
25. Birk OS, Elias D, Weiss AS et al. NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. J Autoimmun 1996 9 : 159 66.
26. Krause I, Tomer Y, Elias D et al. Inhibition of diabetes in NOD mice by idiotypic induction of SLE. J Autoimmun 1999 13 : 49 55.
27. Elias D, Cohen IR. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277. Diabetes 1995 44 : 1132 8.
28. Ablamunits V, Elias D, Reshef T, Cohen IR. Islet T cells secreting IFN-gamma in NOD mouse diabetes: arrest by p277 peptide treatment. J Autoimmun 1998 11 : 73 81.
29. Elias D, Meilin A, Ablamunits V et al. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 1997 46 : 758 64.
30. Quintana FJ, Rotem A, Carmi P, Cohen IR. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol 2000 165 : 6148 55.
31. Santos RR Jr., Sartori A, De Franco M et al. Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis. Hum Gene Ther 2005 16 : 1338 45.
32. Pavin EA, Zollner RL. Implantation of NOD mice in Brazil: contribution of this animal model to diabetes and autoimmune diseases studies. Brazilian Archives of Endocrinology and Metabolism 1994 38 : 105 8.
33. Ventura-Oliveira VCD, Zanin ME, Castro GM, Moreira Filho DC, Zollner RL. Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Braz J Med Biol Res 2002 35 : 1347 55.
34. Portaro FC, Hayashi MA, de Arauz LJ et al. The Mycobacterium leprae hsp65 displays proteolytic activity. Mutagenesis studies indicate that the M. leprae hsp65 proteolytic activity is catalytically related to the HsIVU protease. Biochemistry 2002 41 : 7400 6.
35. Lowrie DB, Silva CL, Colston MJ, Ragno S, Tascon RE. Protectionagainst tuberculosis by a plasmid DNA vaccine. Vaccine 1997 15 : 834 8.
36. Lowrie DB, Tascon RE, Colston MJ, Silva CL. Towards a DNA vaccine against tuberculosis. Vaccine 1994 12 : 1537 40.
37. Syrengelas AD, Chen TT, Levy R. DNA immunization induces protective immunity against B-cell lymphoma. Nat Med 1996 2 : 1038 41.
38. Coon B, An LL, Whitton JL, von Herrath MG. DNA immunization to prevent autoimmune diabetes. J Clin Invest 1999 104 : 189 94.
39. Ruiz PJ, Garren H, Ruiz IU et al. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol 1999 162 : 3336 41.
40. Quintana FJ, Carmi P, Cohen IR. DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J Immunol 2002 169 : 6030 5.
41. DiLorenzo TP, Serreze DV. The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice. Immunol Rev 2005 204 : 250 63.
42. Goudy KS, Tisch R. Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol 2005 24 : 307 26.
43. Walter U, Toepfer T, Dittmar KE et al. Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A (g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes. Diabetologia 2003 46 : 1106 14.
44. Jaeschke A, Rincon M, Doran B et al. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci USA 2005 102 : 6931 5.
45. van Eden W, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005 5 : 318 30.
46. Suri-Payer E, Amar AZ, Thornton AM, Shevach EM. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998 160 : 1212 18.
47. Takahashi T, Sakaguchi S. Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease. Curr Mol Med 2003 3 : 693 706.
48. Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000 164 : 183 90.
49. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999 190 : 995 1004.
50. Homann D, Holz A, Bot A et al. Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity 1999 11 : 463 72.
51. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998 188 : 287 96.