Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis

Human Gene Therapy

Volumn 16, Issue 11, 2005, Pages 1338-1345

  Santos Jr , Rubens R ^a   Sartori, Alexandrina ^a,b   De Franco, Marcelo ^c   Filho, Orlando G R ^c   Coelho Castelo, Arlete A M ^a   Bonato, Vânia L D ^a   Cabrera, Wafa H K ^c   Ibañez, Olga M ^c   Silva, Célio L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; PLASMID VECTOR; PRISTANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; DISEASE EXACERBATION; DNA VECTOR; DRUG EFFECT; FEMALE; HISTOPATHOLOGY; IMMUNOMODULATION; MALE; MOUSE; MYCOBACTERIUM LEPRAE; NONHUMAN; PROPHYLAXIS; SEQUENCE HOMOLOGY; TUBERCULOSIS; VACCINATION;

ANIMALS; ARTHRITIS; BACTERIAL PROTEINS; CHAPERONINS; DISEASE MODELS, ANIMAL; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-12; MICE;

ANIMALIA; MAMMALIA; MURINAE; MYCOBACTERIUM LEPRAE;

EID: 27744486100     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2005.16.1338     Document Type: Article

References (56)

1. AFEK, A., GEORGE, J., and GILBURD, B. (2000). Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J. Autoimmun. 14, 115-121.
2. ARAUJO, L.M., RIBEIRO, O.G., SIQUEIRA, M., DE FRANCO, M., STAROBINAS, N., MASSA, S., CABRERA, W.H., MOUTON, D., SEMAN, M., and IBANEZ, O.M. (1998). Innate resistance to infection by intracellular bacterial pathogens differs in mice selected for maximal or minimal acute inflammatory response. Eur. J. Immunol. 28, 2913-2920.
3. BEDWELL, A.E., ELSON, C.J., and HINTON, C.E. (1987). Immunological involvement in the pathogenesis of pristane-induced arthritis. Scand. J. Immunol. 25, 393.
4. + Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis. J. Immunol. 159, 3692-3697.
5. BIOZZI, G., RIBEIRO, O.G., SARAN, A., ARAUJO, ML., MARIA, D.A., DE FRANCO, M., CABRERA, W.K., SANT'ANNA, O.A., MASSA, S., COVELLI, V., MOUTON, D., NEVEU, T., SIQUEIRA, M., and IBANEZ, O.M. (1998). Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis 19, 337-346.
6. BOCCACCIO G.L., MOR F., and STEINMAN L. (1999). Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis. Int. Immunol. 11, 289-296.
7. BOE, A., BAIOCCHI, M., and CARBONATTO, M. (1999). Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis. Cytokine 11, 1057-1064.
8. BONATO, V.L.D., LIMA, V.M., TASCON, R.E., LOWRIE, D.B., and SILVA, C.L. (1998). Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect. Immun. 66, 169-175.
9. + cells, interferon-γ recovery and reduction of lung injury. Immunology 113, 130-138.
10. BRAS, A., and AGUAS, A.P. (1996). Diabetes-prone NOD mice are resistant to Mycobacterium avium and the infection prevents autoimmune disease. Immunology 89, 20-25.
11. BUTLER, D.M., MALFAIT, A.M., and MAINI, R.N. (1999). Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis. Eur. J. Immunol. 29, 2205-2212.
12. DANIELI, M.G., MARKOVITS, D., and GABRIELLI, A. (1992). Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein. Clin. Immunol. Immunopathol. 64, 121-128.
13. ELIAS, D., RESHEF, T., and BIRK, O.S. (1991). Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. U.S.A. 88, 3088-3091.
14. FEIGE, U., and VAN EDEN, W. (1996). Infection, autoimmunity and autoimmune disease. EXS 77, 359-373.
15. FIELD, M., CHU, C., FELDMANN, M., and MAINI, R.N. (1991). Interleukin-6 localisation in the synovial membrane in rheumatoid arthritis. Rheumatol. Int. 11, 45-50.
16. GILKESON, G.S., RUIZ, P., and PIPPEN, A.M. (1996). Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. J. Exp. Med. 183, 1389-1397.
17. GUPTA, M.M., RAGHUNATH, D., KHER, S.K., and RADHAKRISHNAN, A.P. (1991). Human leucocyte antigen and insulin dependent diabetes mellitus. J. Assoc. Physicians India 39, 540-543.
18. HASSETT, D.E., ZHANG, J., and SLIFKA, M. (2000). Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization. J. Virol. 74, 2620-2627.
19. HELLE, M., BOEIJE, L., and DE GROOT, E. (1991). Detection of IL-6 in biological fluids: Synovial fluids and sera. J. Immunol. Methods 138, 47-56.
20. HOGERVORST, E.J., SCHOULS, L., and WAGENAAR, J.P. (1991). Modulation of experimental autoimmunity: Treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus. Infect. Immun. 59, 2029-2035.
21. IBANEZ, O.M., STIFFEL, C., RIBEIRO, O.G., CABRERA, W.K., MASSA, S., DE FRANCO, M., SANT'ANNA, O.A., DECREUSEFOND, C., MOUTON, D., and SIQUEIRA, M. (1992). Genetics of nonspecific immunity. I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness. Eur. J. Immunol. 22, 2555-2563.
22. JOOSTEN, L.A., LUBBERTS, E., HELSEN, M.M., and VAN DEN BERG, W.B. (1997). Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J. Immunol. 159, 4094-4102.
23. KALLMANN, B.A., LAMPETER, E.F., and HANIFI-MOGHADDAM, P. (1999). Cytokine secretion patterns in twins discordant for type I diabetes. Diabetologia 42, 1080-1085.
24. KAUFMANN, S.H. (1990). Heat shock proteins: A link between rheumatoid arthritis and injection? Curr. Opin. Rheumatol. 2, 430-435.
25. KEREN, P., GEORGE, J., and SHAISH, A. (2000). Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: Establishment of a combined model and association with heat shock protein 65 immunity. Diabetes 49, 1064-1069.
26. KOBAYASHI, H., OHSHIMA, S., and NISHIOKA, K. (2002). Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: Evidence that interleukin 6 is essential for induction of AIA. J. Rheumatol. 29, 1176-1182.
27. KRIEG, A.M. (2001). From bugs to drugs: Therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA. Antisense Nucleic Acid Drug Dev. 11, 181-188.
28. LOPEZ-GUERRERO, J.A., LOPEZ-BOTE, J.P., and ORTIZ, M.A. (1993). Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein. Infect. Immun. 61, 4225-4231.
29. LOWRIE, D.B., TASCON, R.E., and BONATO, V.L. (1999). Therapy of tuberculosis in mice by DNA vaccination. Nature 400, 269-271.
30. MALFAIT, A.M., BUTLER, D.M., and PRESKY, D.H. (1998). Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin. Exp. Immunol. 111, 377-383.
31. MAURI, C., WILLIAMS, R.O., WALMSLEY, M., and FELDMANN, M. (1996). Relationship between Thl/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur. J. Immunol. 26, 1511-1518.
32. MCINTYRE, K.W., SHUSTER, D.J., and GILLOOLY, K.M. (1996). Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur. J. Immunol. 26, 2933-2938.
33. MOTTONEN, M., ISOMAKI, P., and SAARIO, R. (1998). Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells. Br. J. Rheumatol. 37, 1207-1214.
34. PORTTER, M., and WAX, J.S. (1981). Genetics of susceptibility to plasmocytomas in Balb/cJ with a brief description of pristane-induced arthritis. J. Immunol. 127, 1591-1595.
35. QUINTANA, F.J., ROTEM, A., CARMI, P., and COHEN, I.R. (2000). Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity. J. Immunol. 165, 6148-6155.
36. RAGNO, S., COLSTON, M.J., and LOWRIE, D.B. (1997). Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65. Arthritis Rheum. 40, 277-283.
37. ROOK, G., THOMPSON, S., and BUCKLEY, M. (1991). The role of oil and agalactosyl IgG in the induction of arthritis in rodent models. Eur. J. Immunol. 21, 1027-1032.
38. SILVA, C.L., and LOWRIE, D.B. (2000). Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis. Infect. Immun. 68, 3269-3274.
39. SILVA, C.L., SILVA, M.F., PIETRO, R.C., and LOWRIE, D.B. (1996). Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect. Immun. 64, 2400-2407.
40. + T-cell dependent. Immunology 90, 81-86.
41. STEVENSON, F.K., LINK, C.J., Jr., and TRAYNOR, A. (1999). DNA vaccination against multiple myeloma. Semin. Hematol. 36, 38-42.
42. STIFELL, C., IBANEZ, O.M., and RIBEIRO, O.G. (1990). Genetics of acute inflammation: Inflammatory reaction in inbred lines of mice and their interline crosses. Exp. Clin. Immunogenet. 7, 221-233.
43. TANAKA, S., KIMURA, Y., and MITANI, A. (1999). Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis. J. Immunol. 163, 5560-5565.
44. THOMPSON, S.J., and ELSON, C.J. (1993). Susceptibility to arthritis is altered with changes in bowel flora. Immunol. Lett. 36, 227-232.
45. THOMPSON, S.J., ROOK, G.A., and BREALEY, R.J. (1990). Autoimmune reactions to heat-shock proteins in pristane-induced arthritis. Eur. J. Immunol. 20, 2479-2484.
46. THOMPSON, S.J., THOMPSON, H.S.G., and HARPER, N. (1993). Prevention of pristane-induced arthritis by the oral administration of type II collagen. Immunology 79, 152-157.
47. THOMPSON, S.J., FRANCIS, J.N., and SIEW, L.K. (1998). An immunodominant epitope from mycobacterial 65-kDa shock protein against pristane-induced arthritis. J. Immunol. 160, 4628-4634.
48. ULMANSKY, R., COHEN, C.J., and SZAFER, F. (2002). Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion. J. Immunol. 168, 6463-6469.
49. + T cells against influenza virus induced by vaccination with nucleoprotein DNA. J. Virol. 72, 5648-5653.
50. VAN EDEN, W. (1991). Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immunol. Rev. 121, 5-28.
51. VIGAR, N.D., CABRERA, W.H., and ARAUJO, L.M. (2000). Pristane-induced arthritis in mice selected for maximal or minimal acute inflammatory reaction. Eur. J. Immunol. 30, 431-437.
52. WAISMAN, A., RUIZ, P.J., and HIRSCHBERG, D.L. (1996). Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat. Med. 2, 899-905.
53. WENDLING, D., RACADOT, E., and WIJDENES, J. (1993). Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J. Rheumatol. 20, 259-262.
54. WINFIELD, J., and JARJOUR, W. (1991). Do stress proteins play a role in arthritis and autoimmunity? Immunol. Rev. 121, 193-220.
55. WOLFF, J.A., LUDTKE, J.J., and ACSADI, G. (1992). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363-369.
56. WOOLEY, P.H., SEIBOLD, J.R., WHALEN, J.D., and CHAPDELAINE, J.M. (1989). Pristane-induced arthritis: The immunologic and genetic features of an experimental murine model of autoimmune disease. Arthritis Rheum. 32, 1022-1030.