Protection against tuberculosis by a plasmid DNA vaccine

Vaccine

Volumn 15, Issue 8, 1997, Pages 834-838

  Lowrie, D B ^c   Silva, C L ^b   Colston, M J ^a   Ragno, S ^a   Tascon, R E ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE

Author keywords

Cytotoxicity; IFN; Tuberculosis

Indexed keywords

BCG VACCINE; CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSFECTION; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; TUBERCULOSIS; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; CHAPERONINS; CLONE CELLS; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; MYCOBACTERIUM LEPRAE; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; TUBERCULOSIS; VACCINES, DNA;

EID: 0030743496     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00073-X     Document Type: Conference Paper

References (9)

1. Silva, C.L. and Lowrie, D.B. A single mycobacterial protein (hsp65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis. Immunology 1994, 82, 244-248.
2. Taswell, C. Limiting dilution assays for the determination of immunocompetent cell frequencies.I. Data analysis. J. Immunol. 1981, 126, 1614-1619.
3. Silva, C.L., Silva, M.F., Pietro, R.C.L.R. and Lowrie, D.B. Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65. Immunology 1994, 83, 341-346.
4. Silva, C.L., Pietro, R.C.L.R., Januario, A., Bonato, V.L.D., Lima, V.M.F., DaSilva, M.F. and Lowrie, D.B. Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65. Immunology 1995, 86, 519-524.
5. Gautier, C., Mehtali, M. and Lathe, R. A ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter. Nucl. Acids Res. 1989, 17, 8389
6. Freeman, G.J., Borriello, F., Hodes, R.J., Reiser, H., Gribben, J.G., Ng, J.W., Kim, J., Goldberg, J.M., Hathcock, K., Laszlo, G., Lombard, LA., Wang, S., Gray, G.S., Nadler, L.M. and Sharpe, A.M. Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J. Exp. Med. 1993, 178, 2185-2192.
7. Walker, K.B., Butler, R. and Colston, M.J. Role of Th-1 lymphocytes in the development of protective immunity against Mycobacterium leprae. Analysis of lymphocyte function by polymerase chain reaction detection of cytokine messenger RNA. J. Immunol. 1992, 148, 1885-1889.
8. Sorensen, A.L., Nagai, S., Houen, G., Andersen, P. and Andersen, A.B. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 1995, 63, 1710-1717.
9. Thole, J.E., Stabel, L.F., Suykerbuyk, M.E., DeWit, M.Y., Klatser, P.R., Kolk, A.M. and Hartskeerl, R.A. A major immunogenic 36000 molecular weight antigen from Mycobacterium leprae contains an immunoreactive region of proline-rich repeats. Infect. Immun. 1990, 58, 80-87.