메뉴 건너뛰기




Volumn 22, Issue 3, 2007, Pages 217-233

The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV

Author keywords

[No Author keywords available]

Indexed keywords

DNA; KU ANTIGEN; KU80 PROTEIN; LIGASE; UNCLASSIFIED DRUG; XRCC4 PROTEIN;

EID: 34547845825     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gem007     Document Type: Article
Times cited : (43)

References (87)
  • 1
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent, D. C., Hoeijmakers, J. H. and Kanaar, R. (2001) Chromosomal stability and the DNA double-stranded break connection. Nat.Rev.Genet., 2, 196-206.
    • (2001) Nat.Rev.Genet , vol.2 , pp. 196-206
    • van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K. K. and Jackson, S. P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat.Genet., 27, 247-254.
    • (2001) Nat.Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 2642524392 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations
    • Pfeiffer, P., Goedecke, W., Kuhfittig-Kulle, S. and Obe, G. (2004) Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations. Cytogenet. Genome Res., 104, 7-13.
    • (2004) Cytogenet. Genome Res , vol.104 , pp. 7-13
    • Pfeiffer, P.1    Goedecke, W.2    Kuhfittig-Kulle, S.3    Obe, G.4
  • 4
    • 19344370467 scopus 로고    scopus 로고
    • Mechanism of DNA double-strand break repair by non-homologous end joining
    • Hefferin, M. L. and Tomkinson, A. E. (2005) Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair (Amst.), 4, 639-648.
    • (2005) DNA Repair (Amst.) , vol.4 , pp. 639-648
    • Hefferin, M.L.1    Tomkinson, A.E.2
  • 5
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques, F. and Haber, J. E. (1999) Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev., 63, 349-404.
    • (1999) Microbiol. Mol. Biol. Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 6
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm, K., Kruger, I., Thompson, L. H. and Löbrich, M. (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol., 23, 5706-5715.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Löbrich, M.4
  • 7
    • 0033006852 scopus 로고    scopus 로고
    • Ku, a DNA repair protein with multiple cellular functions?
    • Featherstone, C. and Jackson, S. P. (1999) Ku, a DNA repair protein with multiple cellular functions? Mutat. Res., 434, 3-15.
    • (1999) Mutat. Res , vol.434 , pp. 3-15
    • Featherstone, C.1    Jackson, S.P.2
  • 8
    • 3242875642 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase: The director at the end
    • Meek, K., Gupta, S., Ramsden, D. A. and Lees-Miller, S. P. (2004) The DNA-dependent protein kinase: the director at the end. Immunol. Rev., 200, 132-141.
    • (2004) Immunol. Rev , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 9
    • 20644463916 scopus 로고    scopus 로고
    • The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
    • Ma, Y., Schwarz, K. and Lieber, M. R. (2005) The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst.), 4, 845-851.
    • (2005) DNA Repair (Amst.) , vol.4 , pp. 845-851
    • Ma, Y.1    Schwarz, K.2    Lieber, M.R.3
  • 11
    • 25444475799 scopus 로고    scopus 로고
    • Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: The iterative processing model
    • Ma, Y., Lu, H., Schwarz, K. and Lieber, M. R. (2005) Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model. Cell Cycle, 4, 1193-1200.
    • (2005) Cell Cycle , vol.4 , pp. 1193-1200
    • Ma, Y.1    Lu, H.2    Schwarz, K.3    Lieber, M.R.4
  • 13
    • 0347683431 scopus 로고    scopus 로고
    • Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts
    • Lee, J. W., Blanco, L., Zhou, T., Garcia-Diaz, M., Bebenek, K., Kunkel, T. A., Wang, Z. and Povirk, L. F. (2004) Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J. Biol. Chem., 279, 805-811.
    • (2004) J. Biol. Chem , vol.279 , pp. 805-811
    • Lee, J.W.1    Blanco, L.2    Zhou, T.3    Garcia-Diaz, M.4    Bebenek, K.5    Kunkel, T.A.6    Wang, Z.7    Povirk, L.F.8
  • 14
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • Ahnesorg, P., Smith, P. and Jackson, S. P. (2006) XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell, 124, 301-313.
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 15
    • 31044440630 scopus 로고    scopus 로고
    • Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
    • Buck, D., Malivert, L., de Chasseval, R. et al. (2006) Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell, 124, 287-299.
    • (2006) Cell , vol.124 , pp. 287-299
    • Buck, D.1    Malivert, L.2    de Chasseval, R.3
  • 16
    • 30944455282 scopus 로고    scopus 로고
    • Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV
    • Buck, D., Moshous, D., de Chasseval, R. et al. (2006) Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur. J. Immunol., 36, 224-235.
    • (2006) Eur. J. Immunol , vol.36 , pp. 224-235
    • Buck, D.1    Moshous, D.2    de Chasseval, R.3
  • 17
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll, M., Gennery, A. R., Seidel, J., Concannon, P. and Jeggo, P. A. (2004) An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst.), 3, 1227-1235.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 18
    • 31044446441 scopus 로고    scopus 로고
    • DNA double-strand break repair: A relentless hunt uncovers new prey
    • Sekiguchi, J. M. and Ferguson, D. O. (2006) DNA double-strand break repair: a relentless hunt uncovers new prey. Cell, 124, 260-262.
    • (2006) Cell , vol.124 , pp. 260-262
    • Sekiguchi, J.M.1    Ferguson, D.O.2
  • 19
    • 0032403914 scopus 로고    scopus 로고
    • Rejoining of DNA double-strand breaks in vitro by single-strand annealing
    • Göttlich, B., Reichenberger, S., Feldmann, E. and Pfeiffer, P. (1998) Rejoining of DNA double-strand breaks in vitro by single-strand annealing. Eur. J. Biochem., 258, 387-395.
    • (1998) Eur. J. Biochem , vol.258 , pp. 387-395
    • Göttlich, B.1    Reichenberger, S.2    Feldmann, E.3    Pfeiffer, P.4
  • 22
    • 0034234487 scopus 로고    scopus 로고
    • DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: Implications for Ku serving as an alignment factor in non-homologous DNA end joining
    • Feldmann, E., Schmiemann, V., Goedecke, W., Reichenberger, S. and Pfeiffer, P. (2000) DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res., 28, 2585-2596.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2585-2596
    • Feldmann, E.1    Schmiemann, V.2    Goedecke, W.3    Reichenberger, S.4    Pfeiffer, P.5
  • 23
    • 0034162719 scopus 로고    scopus 로고
    • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    • DiBiase, S. J., Zeng, Z. C., Chen, R., Hyslop, T., Curran, W. J., Jr and Iliakis, G. (2000) DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res., 60, 1245-1253.
    • (2000) Cancer Res , vol.60 , pp. 1245-1253
    • DiBiase, S.J.1    Zeng, Z.C.2    Chen, R.3    Hyslop, T.4    Curran Jr, W.J.5    Iliakis, G.6
  • 28
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H. and Iliakis, G. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res., 34, 6170-6182.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6    Iliakis, G.7
  • 29
    • 0037047387 scopus 로고    scopus 로고
    • BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks
    • Zhong, Q., Chen, C. F., Chen, P. L. and Lee, W. H. (2002) BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J. Biol. Chem., 277, 28641-28647.
    • (2002) J. Biol. Chem , vol.277 , pp. 28641-28647
    • Zhong, Q.1    Chen, C.F.2    Chen, P.L.3    Lee, W.H.4
  • 30
    • 5144225797 scopus 로고    scopus 로고
    • DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
    • Bentley, J., Diggle, C. P., Harnden, P., Knowles, M. A. and Kiltie, A. E. (2004) DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res., 32, 5249-5259.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5249-5259
    • Bentley, J.1    Diggle, C.P.2    Harnden, P.3    Knowles, M.A.4    Kiltie, A.E.5
  • 31
    • 0033855389 scopus 로고    scopus 로고
    • Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
    • Pfeiffer, P., Goedecke, W. and Obe, G. (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 15, 289-302.
    • (2000) Mutagenesis , vol.15 , pp. 289-302
    • Pfeiffer, P.1    Goedecke, W.2    Obe, G.3
  • 32
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A. R. (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell, 108, 171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 33
    • 0035953402 scopus 로고    scopus 로고
    • Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group
    • Wang, H., Zeng, Z. C., Bui, T. A., Sonoda, E., Takata, M., Takeda, S. and Iliakis, G. (2001) Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group. Oncogene, 20, 2212-2224.
    • (2001) Oncogene , vol.20 , pp. 2212-2224
    • Wang, H.1    Zeng, Z.C.2    Bui, T.A.3    Sonoda, E.4    Takata, M.5    Takeda, S.6    Iliakis, G.7
  • 34
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • Wang, H., Rosidi, B., Perrault, R., Wang, M., Zhang, L., Windhofer, F. and Iliakis, G. (2005) DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res., 65, 4020-4030.
    • (2005) Cancer Res , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6    Iliakis, G.7
  • 35
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert, M., Salles, B. and Calsou, P. (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem., 279, 55117-55126.
    • (2004) J. Biol. Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 37
    • 16644373413 scopus 로고    scopus 로고
    • Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells
    • Pfeiffer, P., Feldmann, E., Odersky, A., Kuhfittig-Kulle, S. and Goedecke, W. (2005) Analysis of DNA double-strand break repair by nonhomologous end joining in cell-free extracts from mammalian cells. Methods Mol. Biol., 291, 351-371.
    • (2005) Methods Mol. Biol , vol.291 , pp. 351-371
    • Pfeiffer, P.1    Feldmann, E.2    Odersky, A.3    Kuhfittig-Kulle, S.4    Goedecke, W.5
  • 38
    • 0021063154 scopus 로고
    • X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents
    • Jeggo, P. A. and Kemp, L. M. (1983) X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. Mutat. Res., 112, 313-327.
    • (1983) Mutat. Res , vol.112 , pp. 313-327
    • Jeggo, P.A.1    Kemp, L.M.2
  • 39
    • 0032126552 scopus 로고    scopus 로고
    • XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation
    • Errami, A., He, D. M., Friedl, A. A. et al. (1998) XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucleic Acids Res., 26, 3146-3153.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3146-3153
    • Errami, A.1    He, D.M.2    Friedl, A.A.3
  • 40
    • 0020585842 scopus 로고
    • Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell
    • Stamato, T. D., Weinstein, R., Giaccia, A. and Mackenzie, L. (1983) Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell. Somatic. Cell Genet., 9, 165-173.
    • (1983) Somatic. Cell Genet , vol.9 , pp. 165-173
    • Stamato, T.D.1    Weinstein, R.2    Giaccia, A.3    Mackenzie, L.4
  • 41
    • 0028078579 scopus 로고
    • Mechanisms of overlap formation in nonhomologous DNA end joining
    • Pfeiffer, P., Thode, S., Hancke, J. and Vielmetter, W. (1994) Mechanisms of overlap formation in nonhomologous DNA end joining. Mol. Cell. Biol., 14, 888-895.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 888-895
    • Pfeiffer, P.1    Thode, S.2    Hancke, J.3    Vielmetter, W.4
  • 44
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • Li, Z., Otevrel, T., Gao, Y., Cheng, H. L., Seed, B., Stamato, T. D., Taccioli, G. E. and Alt, F. W. (1995) The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell, 83, 1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.1    Otevrel, T.2    Gao, Y.3    Cheng, H.L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 45
    • 0032971199 scopus 로고    scopus 로고
    • Absence of DNA ligase IV protein in XR-1 cells: Evidence for stabilization by XRCC4
    • Bryans, M., Valenzano, M. C. and Stamato, T. D. (1999) Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat. Res., 433, 53-58.
    • (1999) Mutat. Res , vol.433 , pp. 53-58
    • Bryans, M.1    Valenzano, M.C.2    Stamato, T.D.3
  • 46
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
    • Peterson, S. R., Kurimasa, A., Oshimura, M., Dynan, W. S., Bradbury, E. M. and Chen, D. J. (1995) Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl Acad. Sci. USA, 92, 3171-3174.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 47
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T., O'Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M. and Jeggo, P. A. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res., 64, 2390-2396.
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Löbrich, M.5    Jeggo, P.A.6
  • 48
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm, K. and Löbrich, M. (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc. Natl Acad. Sci. USA, 100, 5057-5062.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Löbrich, M.2
  • 49
    • 0025282247 scopus 로고
    • The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: A review
    • Ward, J. F. (1990) The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int. J. Radiat. Biol., 57, 1141-1150.
    • (1990) Int. J. Radiat. Biol , vol.57 , pp. 1141-1150
    • Ward, J.F.1
  • 50
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • Riballo, E., Kuhne, M., Rief, N. et al. (2004) A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell, 16, 715-724.
    • (2004) Mol. Cell , vol.16 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3
  • 51
    • 15844385545 scopus 로고    scopus 로고
    • Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA
    • Liang, F. and Jasin, M. (1996) Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. J. Biol. Chem., 271, 14405-14411.
    • (1996) J. Biol. Chem , vol.271 , pp. 14405-14411
    • Liang, F.1    Jasin, M.2
  • 52
    • 0033583204 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
    • Calsou, P., Frit, P., Humbert, O., Muller, C., Chen, D. J. and Salles, B. (1999) The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA. J. Biol. Chem., 274, 7848-7856.
    • (1999) J. Biol. Chem , vol.274 , pp. 7848-7856
    • Calsou, P.1    Frit, P.2    Humbert, O.3    Muller, C.4    Chen, D.J.5    Salles, B.6
  • 53
    • 0032934980 scopus 로고    scopus 로고
    • Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts
    • Labhart, P. (1999) Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts. Mol. Cell. Biol., 19, 2585-2593.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 2585-2593
    • Labhart, P.1
  • 54
    • 2942752107 scopus 로고    scopus 로고
    • A paradox in the in vitro end-joining assays
    • Blanco, M. G., Boan, F. and Gomez-Marquez, J. (2004) A paradox in the in vitro end-joining assays. J. Biol. Chem., 279, 26797-26801.
    • (2004) J. Biol. Chem , vol.279 , pp. 26797-26801
    • Blanco, M.G.1    Boan, F.2    Gomez-Marquez, J.3
  • 56
    • 0036682122 scopus 로고    scopus 로고
    • An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    • Delacote, F., Han, M., Stamato, T. D., Jasin, M. and Lopez, B. S. (2002) An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res., 30, 3454-3463.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3454-3463
    • Delacote, F.1    Han, M.2    Stamato, T.D.3    Jasin, M.4    Lopez, B.S.5
  • 58
    • 0024284051 scopus 로고
    • Joining of nonhomologous DNA double strand breaks in vitro
    • Pfeiffer, P. and Vielmetter, W. (1988) Joining of nonhomologous DNA double strand breaks in vitro. Nucleic Acids Res., 16, 907-924.
    • (1988) Nucleic Acids Res , vol.16 , pp. 907-924
    • Pfeiffer, P.1    Vielmetter, W.2
  • 59
  • 60
    • 0025274315 scopus 로고
    • A novel pathway of DNA end-to-end joining
    • Thode, S., Schäfer, A., Pfeiffer, P. and Vielmetter, W. (1990) A novel pathway of DNA end-to-end joining. Cell, 60, 921-928.
    • (1990) Cell , vol.60 , pp. 921-928
    • Thode, S.1    Schäfer, A.2    Pfeiffer, P.3    Vielmetter, W.4
  • 61
    • 0032518434 scopus 로고    scopus 로고
    • Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis - studies on its potential role in DNA-end joining
    • Reichenberger, S. and Pfeiffer, P. (1998) Cloning, purification and characterization of DNA polymerase beta from Xenopus laevis - studies on its potential role in DNA-end joining. Eur. J. Biochem., 251, 81-90.
    • (1998) Eur. J. Biochem , vol.251 , pp. 81-90
    • Reichenberger, S.1    Pfeiffer, P.2
  • 62
    • 0032564469 scopus 로고    scopus 로고
    • DNA end-joining catalyzed by human cell-free extracts
    • Baumann, P. and West, S. C. (1998) DNA end-joining catalyzed by human cell-free extracts. Proc. Natl Acad. Sci. USA, 95, 14066-14070.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14066-14070
    • Baumann, P.1    West, S.C.2
  • 63
    • 0035870583 scopus 로고    scopus 로고
    • Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
    • Wang, H., Zeng, Z. C., Perrault, A. R., Cheng, X., Qin, W. and Iliakis, G. (2001) Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Res., 29, 1653-1660.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1653-1660
    • Wang, H.1    Zeng, Z.C.2    Perrault, A.R.3    Cheng, X.4    Qin, W.5    Iliakis, G.6
  • 64
    • 0037099520 scopus 로고    scopus 로고
    • Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
    • Zhong, Q., Boyer, T. G., Chen, P. L. and Lee, W. H. (2002) Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res., 62, 3966-3970.
    • (2002) Cancer Res , vol.62 , pp. 3966-3970
    • Zhong, Q.1    Boyer, T.G.2    Chen, P.L.3    Lee, W.H.4
  • 65
    • 3042606214 scopus 로고    scopus 로고
    • Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks
    • Sandor, Z., Calicchio, M. L., Sargent, R. G., Roth, D. B. and Wilson, J. H. (2004) Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks. Nucleic Acids Res., 32, 1866-1873.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1866-1873
    • Sandor, Z.1    Calicchio, M.L.2    Sargent, R.G.3    Roth, D.B.4    Wilson, J.H.5
  • 66
    • 0022256461 scopus 로고
    • Mechanisms of nonhomologous recombination in mammalian cells
    • Roth, D. B., Porter, T. N. and Wilson, J. H. (1985) Mechanisms of nonhomologous recombination in mammalian cells. Mol. Cell. Biol., 5, 2599-2607.
    • (1985) Mol. Cell. Biol , vol.5 , pp. 2599-2607
    • Roth, D.B.1    Porter, T.N.2    Wilson, J.H.3
  • 67
    • 3242879122 scopus 로고    scopus 로고
    • The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
    • Lieber, M. R., Ma, Y., Pannicke, U. and Schwarz, K. (2004) The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst.), 3, 817-826.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 817-826
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 68
    • 0037104045 scopus 로고    scopus 로고
    • Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines
    • Merel, P., Prieur, A., Pfeiffer, P. and Delattre, O. (2002) Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines. Oncogene, 21, 5654-5659.
    • (2002) Oncogene , vol.21 , pp. 5654-5659
    • Merel, P.1    Prieur, A.2    Pfeiffer, P.3    Delattre, O.4
  • 69
    • 0037023694 scopus 로고    scopus 로고
    • Repair of sequence-specific 125I-induced double-strand breaks by nonhomologous DNA end joining in mammalian cell-free extracts
    • Odersky, A., Panyutin, I. V., Panyutin, I. G., Schunck, C., Feldmann, E., Goedecke, W., Neumann, R. D., Obe, G. and Pfeiffer, P. (2002) Repair of sequence-specific 125I-induced double-strand breaks by nonhomologous DNA end joining in mammalian cell-free extracts. J. Biol. Chem., 277, 11756-11764.
    • (2002) J. Biol. Chem , vol.277 , pp. 11756-11764
    • Odersky, A.1    Panyutin, I.V.2    Panyutin, I.G.3    Schunck, C.4    Feldmann, E.5    Goedecke, W.6    Neumann, R.D.7    Obe, G.8    Pfeiffer, P.9
  • 70
    • 15444370124 scopus 로고    scopus 로고
    • Processing of DNA for nonhomologous end-joining by cell-free extract
    • Budman, J. and Chu, G. (2005) Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J., 24, 849-860.
    • (2005) EMBO J , vol.24 , pp. 849-860
    • Budman, J.1    Chu, G.2
  • 71
    • 0033231221 scopus 로고    scopus 로고
    • Nonhomologous DNA end joining in cell-free systems
    • Labhart, P. (1999) Nonhomologous DNA end joining in cell-free systems. Eur. J. Biochem., 265, 849-861.
    • (1999) Eur. J. Biochem , vol.265 , pp. 849-861
    • Labhart, P.1
  • 72
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. A. and Jackson, S. P. (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl Acad. Sci. USA, 92, 320-324.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 73
    • 0030746109 scopus 로고    scopus 로고
    • Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
    • Yaneva, M., Kowalewski, T. and Lieber, M. R. (1997) Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J., 16, 5098-5112.
    • (1997) EMBO J , vol.16 , pp. 5098-5112
    • Yaneva, M.1    Kowalewski, T.2    Lieber, M.R.3
  • 74
    • 0031708232 scopus 로고    scopus 로고
    • Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
    • West, R. B., Yaneva, M. and Lieber, M. R. (1998) Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol. Cell. Biol., 18, 5908-5920.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 5908-5920
    • West, R.B.1    Yaneva, M.2    Lieber, M.R.3
  • 75
    • 0037224429 scopus 로고    scopus 로고
    • Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro
    • Lee, J. W., Yannone, S. M., Chen, D. J. and Povirk, L. F. (2003) Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res., 63, 22-24.
    • (2003) Cancer Res , vol.63 , pp. 22-24
    • Lee, J.W.1    Yannone, S.M.2    Chen, D.J.3    Povirk, L.F.4
  • 76
    • 0036293744 scopus 로고    scopus 로고
    • Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair
    • Mahajan, K. N., Nick McElhinny, S. A., Mitchell, B. S. and Ramsden, D. A. (2002) Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol. Cell. Biol., 22, 5194-5202.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 5194-5202
    • Mahajan, K.N.1    Nick McElhinny, S.A.2    Mitchell, B.S.3    Ramsden, D.A.4
  • 79
    • 0033166623 scopus 로고    scopus 로고
    • Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
    • Riballo, E., Critchlow, S. E., Teo, S. H. et al. (1999) Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr. Biol., 9, 699-702.
    • (1999) Curr. Biol , vol.9 , pp. 699-702
    • Riballo, E.1    Critchlow, S.E.2    Teo, S.H.3
  • 80
    • 0346333311 scopus 로고    scopus 로고
    • Human Rad52 facilitates a three-stranded pairing that follows no strand exchange: A novel pairing function of the protein
    • Navadgi, V. M., Dutta, A. and Rao, B. J. (2003) Human Rad52 facilitates a three-stranded pairing that follows no strand exchange: a novel pairing function of the protein. Biochemistry, 42, 15237-15251.
    • (2003) Biochemistry , vol.42 , pp. 15237-15251
    • Navadgi, V.M.1    Dutta, A.2    Rao, B.J.3
  • 81
    • 32944459979 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining
    • Wang, H. C., Chou, W. C., Shieh, S. Y. and Shen, C. Y. (2006) Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res., 66, 1391-1400.
    • (2006) Cancer Res , vol.66 , pp. 1391-1400
    • Wang, H.C.1    Chou, W.C.2    Shieh, S.Y.3    Shen, C.Y.4
  • 82
  • 84
    • 34548398249 scopus 로고    scopus 로고
    • Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1
    • Bau, D. T., Mau, Y. C. and Shen, C. Y. (2005) Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1. Cancer Lett, 240, 1-8.
    • (2005) Cancer Lett , vol.240 , pp. 1-8
    • Bau, D.T.1    Mau, Y.C.2    Shen, C.Y.3
  • 86
    • 0035917489 scopus 로고    scopus 로고
    • Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    • Moshous, D., Callebaut, I., de Chasseval, R. et al. (2001) Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell, 105, 177-186.
    • (2001) Cell , vol.105 , pp. 177-186
    • Moshous, D.1    Callebaut, I.2    de Chasseval, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.