The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay

Contact Dermatitis

Volumn 44, Issue 6, 2001, Pages 357-361

  Dearman, Rebecca J ^a   Wright, Zoe M ^b   Basketter, David A ^b   Ryan, Cindy A ^c   Gerberick, G Frank ^c   Kimber, Ian ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Contact allergy; Hexyl cinnamic aldehyde; Local lymph node assay; Positive controls; Stability

Indexed keywords

CINNAMALDEHYDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CALIBRATION; CELL PROLIFERATION; CONTACT ALLERGY; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; LABORATORY; LYMPH NODE; MOUSE; MOUSE STRAIN; NONHUMAN; RELIABILITY; SENSITIVITY AND SPECIFICITY; SKIN SENSITIZATION; TOXICITY TESTING;

ACROLEIN; ALLERGENS; ANIMALS; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LYMPH NODES; MICE; MICE, INBRED CBA; REPRODUCIBILITY OF RESULTS; THYMIDINE;

EID: 0034990756     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0536.2001.044006357.x     Document Type: Article

References (19)

1. The murine local lymph node assay: A commentary on collaborative studies and new directions
2. The local lymph node assay: Developments and applications
3. Local lymph node assay: Use in hazard and risk assessment
4. Local lymph node assay: Validation for regulatory purposes
5. Statement on the validity of the local lymph node assay for skin sensitisation testing
6. Guidelines for testing of chemicals, No 405
7. Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde
8. Contact sensitization: A new approach to risk assessment
9. A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses
10. Examination of the local lymph node assay for use in contact sensitization risk assessment
11. Use of ranks in one-criterion variance analysis
12. An international evaluation of the murine local lymph node assay and comparison of modified procedures
13. Further evaluation of the local lymph node assay in the final phase of an international collaborative trial
14. Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: An international evaluation
15. Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays
16. An evaluation of the suitability of benzocaine as a positive control skin sensitizer
17. Use of the local lymph node assay for the estimation of relative contact allergenic potency