An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: First round

Toxicology

Volumn 212, Issue 1, 2005, Pages 60-68

  Ehling, G ^a   Hecht, M ^b   Heusener, A ^c   Huesler, J ^d   Gamer, A O ^e   Van Loveren, H ^f   Maurer, Th ^g   Riecke, K ^h   Ullmann, L ⁱ   Ulrich, P ⁱ   Vandebriel, R ^f   Vohr, H W ^h  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c MERCK KGAA   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

^e BASF SE   (Germany)

^f NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^g Swissmedic   (Switzerland)

^h BAYER PHARMA AG   (Germany)

ⁱ RCC Ltd   (Switzerland)

Author keywords

IMDS; Inter laboratory catch up validation; Modified local lymph node assay; Murine local lymph node assay

Indexed keywords

ALDEHYDE; HEXYLCINNAMALDEHYDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; LOCAL LYMPH NODE ASSAY; LYMPH NODE CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; ORGAN WEIGHT; OTITIS; PRIORITY JOURNAL; SKIN MANIFESTATION; VALIDATION PROCESS;

ANIMALS; ENDPOINT DETERMINATION; EUROPE; FEMALE; IRRITANTS; LABORATORIES; LOCAL LYMPH NODE ASSAY; MICE; MICE, INBRED BALB C; SKIN TESTS; SPECIES SPECIFICITY;

MURINAE;

EID: 20444375082     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.04.010     Document Type: Article

References (16)

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