Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay

Journal of Applied Toxicology

Volumn 25, Issue 2, 2005, Pages 129-134

  Takeyoshi, Masahiro ^a   Iida, Kenji ^a   Shiraishi, Keiji ^a   Hoshuyama, Satsuki ^a  

^a CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

Bromodeoxyuridine; Local lymph node assay; Non radioisotopic; Sensitization potency

Indexed keywords

BROXURIDINE; CINNAMALDEHYDE; CITRAL; CONTACT ALLERGEN; DIPHENCYCLOPROPENONE; EUGENOL; GLUTARALDEHYDE; HEXANE; MYRISTIC ACID ISOPROPYL ESTER; PHENYLENEDIAMINE; PROPYLENE; PROPYLENE GLYCOL; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLASSIFICATION; CONTACT SENSITIZATION; CONTROLLED STUDY; FEMALE; HUMAN; LYMPH NODE; MOUSE; NONHUMAN; PARAMETER; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; SKIN SENSITIZATION;

ALLERGENS; ANIMALS; BROMODEOXYURIDINE; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LOCAL LYMPH NODE ASSAY; LYMPH NODES; MICE; MICE, INBRED CBA; PREDICTIVE VALUE OF TESTS; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SKIN TESTS;

MURINAE;

EID: 16844378142     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.1045     Document Type: Article

References (18)

1. Basketter DA, Cadby P. 2004. Reproducible prediction of contact allergenic potency using the local lymph node assay. Contact Derm. 50: 15-17.
2. Basketter DA, Scholes EW. 1992. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem. Toxicol. 30: 65-69.
3. Basketter DA, Gerberick, GF, Kimber I, Loveless SE. 1996. The local lymph node assay: a viable alternative to currently accepted skin sensitization tests. Food Chem. Toxicol. 34: 985-997.
4. Basketter DA, Blaikie L, Dearman RJ, Kimber I, Ryan CA, Gerberick GF, Harvey P, Evans P, White IR, Rycroft RJ. 2000. Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Derma. 42: 344-348.
5. Basketter DA, Gerberick GF, Kimber I. 2001. Measurement of allergenic potency using the local lymph node assay. Trends Pharmacol. Sci. 22: 264-265.
6. Bruning JL, Kintz BL. 1997. Computational Handbook of Statistics (4th edn), Addison-Wesley: Boston, MA.
7. Buehler EV. 1995. Prospective testing for delayed contact hypersensitivity in guinea pigs. The Buehler method. In Methods in Immunotoxicology, Burleson GR, Dean JH, Munson AE (eds). Wiley-Liss: New York, NY: 343-356.
8. Dearman RJ, Hilton J, Evans P, Harvey P, Basketter DA, Kimber I. 1998. Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde. J. Appl. Toxicol. 18: 281-284.
9. Gerberick GF, Robinson MK, Ryan CA, Dearman RJ, Kimber I, Basketter DA, Wright Z, Marks JG. 2001. Contact allergenic potency: correlation of human and local lymph node assay data. Am. J. Contact Derm. 12: 156-161.
10. Griem P, Goebel C, Scheffler H. 2003. Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data. Regul. Toxicol. Pharmacol. 38: 269-290.
11. Kimber, I. 2002. Reduction, refinement and replacement: putting the immune system to work - the FRAME Annual Lecture 2002. Altern. Lab. Anim. 30: 569-579.
12. Kimber I, Dearman RJ, Scholes EW, Basketter DA. 1994. The local lymph node assay: developments and applications. Toxicology 93: 13-31.
13. Kimber I, Dearman RJ, Basketter DA, Ryan CA, Gerberick GF. 2002. The local lymph node assay: past, present and future. Contact Derm. 47: 315-328.
14. Magnusson B, Kligman AM. 1969. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 52: 268-276.
15. Organization for Economic Corporation and Development (OECD). 2002. Skin Sensitisation: Local Lymph Node Assay, TG-429 (adopted: 24th April 2002). OECD: Paris.
16. Takeyoshi M, Yamasaki K, Yakabe Y, Takatsuki M, Kimber I. 2001. Development of non-radioisotopic endpoint of murine local lymph node assay based on 5-bromo-2′-deoxyuridine (BrdU) incorporation. Toxicol. Lett. 119: 203-208.
17. Takeyoshi M, Sawakil M, Yamasaki K, Kimber I. 2003. Assessment of statistic analysis in non-radioisotopic local lymph node assay (Non-RI-LLNA) with α-hexylcinnamic aldehyde as an example. Toxicology 191: 259-263.
18. United States Environmental Protection Agency (USEPA). 2003. Health Effects Test Guidelines OPPTS 870.2600 Skin Sensitization. USEPA: Washington DC.