Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: Primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals

Archives of Toxicology

Volumn 74, Issue 12, 2001, Pages 733-744

  Ulrich, P ^a   Streich, J ^a   Suter, W ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Contact allergy; Contact photoallergy; Irritation; Local lymph node assay (LLNA); Photoirritation

Indexed keywords

ALLERGEN; CHEMICAL AGENT;

ALLERGENICITY; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTACT ALLERGY; FEMALE; LYMPH NODE; LYMPH NODE HYPERPLASIA; MOUSE; NONHUMAN; PHOTOREACTIVITY; PRIORITY JOURNAL; RADIOACTIVITY; SKIN IRRITATION; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; CELL COUNT; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, PHOTOTOXIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EAR, EXTERNAL; FEMALE; HYPERPLASIA; LOCAL LYMPH NODE ASSAY; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; ORGAN SIZE; REPRODUCIBILITY OF RESULTS; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS; TOXICITY TESTS;

ANIMALIA; MURINAE;

EID: 0034467707     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000192     Document Type: Article

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