Influence of application vehicle on skin sensitization to methylchloroisothiazolinone/methylisothiazolinone: An analysis using the local lymph node assay

Contact Dermatitis

Volumn 41, Issue 6, 1999, Pages 325-329

  Warbrick, E Vicky ^a   Dearman, Rebecca J ^a   Basketter, David A ^b   Kimber, Ian ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Acetone; Acetone:olive oil; Dimethylformamide; Dimethylsulfoxide; Isothiazolinones; Local lymph node assay; Methyl ethyl ketone; Propylene glycol; Skin sensitization; Vehicles

Indexed keywords

2 BUTANONE; ACETONE; DIMETHYL SULFOXIDE; ISOTHIAZOLE DERIVATIVE; N,N DIMETHYLFORMAMIDE; OLIVE OIL; PRESERVATIVE; PROPYLENE GLYCOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CONTROLLED STUDY; FEMALE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SKIN SENSITIZATION;

EID: 0033397252     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1999.tb06181.x     Document Type: Article

References (19)

1. 1. Kimber I, Basketter D A. The murine local lymph node assay: a commentary on collaborative studies and new directions. Fd Chem Toxicol 1992: 30: 165-169.
2. 2. Kimber I, Dearman R J, Scholes E W, Basketter D A. The local lymph node assay: developments and applications. Toxicology 1994: 93: 13-31.
3. 3. Kimber I, Basketter D A. Contact sensitization: a new approach to risk assessment. Hum Ecol Risk Assess 1997: 3: 385-395.
4. 4. Basketter D A, Dearman R J, Hilton J, Kimber I. Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay. Contact Dermatitis 1997: 36: 97-100.
5. 5. Hilton J, Dearman R J, Harvey P, Evans P, Basketter D A, Kimber I. Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of form-aldehyde with glutaraldehyde. Am J Contact Derm 1998: 9: 29-33.
6. 6. Dearman R J, Hilton J, Evans P, Harvey P, Basketter D A, Kimber I. Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde. J Appl Toxicol 1998: 18: 281-284.
7. 7. Kligman A M. The identification of contact allergens by human assay, (II). Factors influencing the induction and measurement of allergic contact dermatitis. J Invest Derm 1966: 47: 375-392.
8. 8. Marzulli F N, Maibach H I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976: 2: 325-329.
9. 9. Heylings J R, Clowes H M, Cumberbatch M, Dearman R J, Fielding I, Hilton J, Kimber I. Sensitization to 2,4-dinitrochlorobenzene: influence of vehicle on absorption and lymph node activation. Toxicology 1996: 109: 57-65.
10. 10. Dearman R J, Cumberbatch M, Hilton J, Clowes H M, Fielding I, Heylings J R, Kimber I. Influence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate. Fund Appl Toxicol 1996: 33: 24-30.
11. 11. De Groot A C, Weyland J W. Kathon CG: a review. J Am Acad Derm 1988: 18: 350-358.
12. 12. Basketter D A, Lea L J, Dickens A, Briggs D, Pate I, Dearman R J, Kimber I. A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses. J Appl Toxicol 1999: 19: 261-266.
13. 13. Kimber I, Hilton J, Dearman R J, Gerberick G F, Ryan C A, Basketter D A, Scholes E W, Ladics G S, Loveless S E, House R V, Guy A. An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 1995: 103: 63-73.
14. 14. Kimber I, Hilton J, Dearman R J, Gerberick G F, Ryan C A, Basketter D A, Lea L, House R V, Ladics G S, Loveless S E, Hastings K L. Assessment of the skin sensitizing potential of topical medicaments using the local lymph node assay: an interlaboratory trial. J Toxicol Environ Health 1998: 53: 563-579.
15. 15. De Groot A C, Liem D H, Weyland J W. Kathon®CG: cosmetic allergy and patch test sensitization. Contact Dermatitis 1985: 12: 76-80.
16. 16. Björkner B, Bruze M, Dahlquist I, Fregert S, Gruvberger B, Persson K. Contact allergy to the preservative Kathon®CG. Contact Dermatitis 1986: 14: 85-90.
17. 17. Hjorth N, Roed-Petersen J. Patch test sensitivity to Kathon®CG. Contact Dermatitis 1986: 14: 155-157.
18. 18. Hannuksela M. Rapid increase in contact allergy to Kathon®CG in Finland. Contact Dermatitis 1986: 15: 211-214.
19. 19. Kimber I, Dearman R J. Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential. Fd Chem Toxicol 1991: 29: 125-129.