The murine local lymph node assay: Search for an alternative, more adequate, vehicle than acetone/olive oil (4:1)

Contact Dermatitis

Volumn 34, Issue 6, 1996, Pages 428-430

  Montelius, Johan ^a   Boman, Anders ^a   Wahlkvist, Helen ^a   Wahlberg, Jan E ^a,b  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acetone; Acetone olive oil (4:1); Contact allergy; Dimethylformamide; LLNA; Local lymph node assay; Olive oil; Predictive testing; Vehicle

Indexed keywords

ACETONE; CONTACT ALLERGEN; DRUG VEHICLE; OLIVE OIL;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; LYMPH NODE; MOUSE; NONHUMAN; PRACTICE GUIDELINE; SCREENING;

EID: 0029846916     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1996.tb02249.x     Document Type: Article

References (7)

1. Kimber I, Basketter D A. The murine local lymph node assay: a commentary on collaborative studies and new directions. Food Chem Toxicol 1992: 30: 165-169.
2. OECD. Organisation for Economic Cooperation and Development 1993: Guideline 406: Skin sensitisation.
3. Robbins M, Nicklin S, Miller K. Comparison of 2 murine test methods for potential contact sensitisers. The Toxicologist 1991: 11: abstr 1102.
4. Ikarashi Y, Tsukamoto Y, Tsuchiva T, Nakamura A. Influence of irritants on lymph node cell proliferation and the detection of contact sensitivity to metal salts in the murine local lymph node assay. Contact Dermatitis 1993: 29: 128-132.
5. Montelius J, Wahlkvist H, Boman A, Fernström P, Gråbergs L, Wahlberg JE. Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants. Acta Dermato-venereologica 1994: 74: 22-21.
6. Edwards D A, Soranno T M, Amoruso M A, House R V, Tummey A C, Trimmer G W, Thomas P T, Ribeiro P L. Screening petrochemicals for contact hypersensitivity potential: a comparison of the murine local lymph node assay with the guinea pig and human test data. Fundam Appl Toxicol 1994: 23: 179-187.
7. Malmkvist Padoan S, Pettersson A, Svensson Å. Olive oil as a cause of contact allergy in patients with venous eczema, and occupationally. Contact Dermatitis 1990: 23: 73-76.