메뉴 건너뛰기




Volumn 5, Issue 3, 2007, Pages 185-194

Novel anti-arrhythmic drugs for atrial fibrillation management

Author keywords

Atrial fibrillation; HERG; Pharmacotherapy; Proarrhythmia; Ventricular fibrillation

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; 2 [7 [3 (4 CYANOPHENOXY) 2 HYDROXYPROPYL] 9 OXA 3,7 DIAZABICYCLO[3.3.1]NON 3 YL]ETHYLCARBAMIC ACID TERT BUTYL ESTER; 2' (4 METHOXYPHENYLACETAMIDOMETHYL) N [2 (3 PYRIDYL)ETHYL] 2 BIPHENYLCARBOXAMIDE; 2' (BENZYLOXYCARBONYLAMINOMETHYL) BIPHENYL 2 CARBOXYLIC ACID 2 (2 PYRIDYL)ETHYLAMIDE; 2' [[2 (4 METHOXYPHENYL) ACETYLAMINO] METHYL] BIPHENYL 2 CARBOXYLIC ACID 2,4 DIFLUORO BENZYLAMIDE; 4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; 4 CYCLOPROPYLAMINO 3,4 DIHYDRO 2,2 DIMETHYL 6 (4 METHOXYPHENYLACETYLAMINO) 7 NITRO 2H 1 BENZOPYRAN 3 OL; AMIODARONE; ANTIARRHYTHMIC AGENT; AZIMILIDE; C 9356; CANDESARTAN; CARBACHOL; CARDIOVASCULAR AGENT; CORREOLIDE; DIPHENYLPHOSPHINE OXIDE 1; GAP JUNCTION PROTEIN; IBUTILIDE; IRBESARTAN; LORATADINE; LOSARTAN; NIP 141; NIP 142; PLACEBO; PROPAFENONE; ROTIGAPTIDE; S 20951; S 9947; TERTIAPIN Q; UNCLASSIFIED DRUG; VERNAKALANT; ZATEBRADINE; NEW DRUG; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

EID: 34547596545     PISSN: 15701611     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016107781024073     Document Type: Review
Times cited : (22)

References (90)
  • 1
    • 30844452012 scopus 로고    scopus 로고
    • Controversies in atrial fibrillation
    • Nattel S, Opie LH. Controversies in atrial fibrillation. Lancet 2006; 367: 262-272.
    • (2006) Lancet , vol.367 , pp. 262-272
    • Nattel, S.1    Opie, L.H.2
  • 2
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, felcainide, or placebo. The cardiac arrhythmia suppression trial
    • Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. Mortality and morbidity in patients receiving encainide, felcainide, or placebo. The cardiac arrhythmia suppression trial. N Engl J Med 1991; 324: 781-788.
    • (1991) N Engl J Med , vol.324 , pp. 781-788
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, L.B.3    Peters, R.W.4    Obias-Manno, D.5    Barker, A.H.6
  • 3
    • 0025542167 scopus 로고
    • Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized trials
    • Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized trials. Circulation 1990; 82: 1106-1116.
    • (1990) Circulation , vol.82 , pp. 1106-1116
    • Coplen, S.E.1    Antman, E.M.2    Berlin, J.A.3    Hewitt, P.4    Chalmers, T.C.5
  • 4
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
    • Waldo AL, Camm AJ, deRuyter H, Friedman PL, MacNeil DJ, Pauls JF, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 1996; 348: 7-12.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    deRuyter, H.3    Friedman, P.L.4    MacNeil, D.J.5    Pauls, J.F.6
  • 5
    • 0035902567 scopus 로고    scopus 로고
    • Efficacy of Dofetilide in the Treatment of Atrial Fibrillation-Flutter in Patients with Reduced Left Ventricular Function: A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) Substudy
    • Pedersen OD, Bagger H, Keller N, Marhcant B, Kober L, Torp-Pedersen C. Efficacy of Dofetilide in the Treatment of Atrial Fibrillation-Flutter in Patients with Reduced Left Ventricular Function: A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) Substudy. Circulation 2001; 104: 292-296.
    • (2001) Circulation , vol.104 , pp. 292-296
    • Pedersen, O.D.1    Bagger, H.2    Keller, N.3    Marhcant, B.4    Kober, L.5    Torp-Pedersen, C.6
  • 7
    • 0028821910 scopus 로고
    • Proarrhythmia with class III antiarrhythmic drugs: Definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications
    • Hohnloser SH, Singh BN. Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications. J Cardiovasc Electrophysiol 1995; 6: 920-936.
    • (1995) J Cardiovasc Electrophysiol , vol.6 , pp. 920-936
    • Hohnloser, S.H.1    Singh, B.N.2
  • 8
    • 0037050001 scopus 로고    scopus 로고
    • New ideas about atrial fibrillation 50 years on
    • Nattel S. New ideas about atrial fibrillation 50 years on. Nature 2002;415:219-226.
    • (2002) Nature , vol.415 , pp. 219-226
    • Nattel, S.1
  • 9
    • 0343952982 scopus 로고    scopus 로고
    • Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation
    • Li D, Benardeau A, Nattel S. Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation. Circulation 2000; 102: 104-112.
    • (2000) Circulation , vol.102 , pp. 104-112
    • Li, D.1    Benardeau, A.2    Nattel, S.3
  • 10
    • 0024511793 scopus 로고
    • Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm
    • Suttorp MJ, Kingma JH, Lie AH, Mast EG. Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. Am J Cardiol 1989; 63: 693-696.
    • (1989) Am J Cardiol , vol.63 , pp. 693-696
    • Suttorp, M.J.1    Kingma, J.H.2    Lie, A.H.3    Mast, E.G.4
  • 12
    • 0035113546 scopus 로고    scopus 로고
    • Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs
    • Fareh S, Benardeau A, Nattel S. Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs. Cardiovasc Res 2001; 49: 762-770.
    • (2001) Cardiovasc Res , vol.49 , pp. 762-770
    • Fareh, S.1    Benardeau, A.2    Nattel, S.3
  • 13
    • 0032551211 scopus 로고    scopus 로고
    • What lessons can be learnt from withdrawal of mibefradil from the market?
    • Po AL, Zhang WY. What lessons can be learnt from withdrawal of mibefradil from the market? Lancet 1998; 351: 1829-1830.
    • (1998) Lancet , vol.351 , pp. 1829-1830
    • Po, A.L.1    Zhang, W.Y.2
  • 15
    • 0035814771 scopus 로고    scopus 로고
    • Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation
    • Brundel BJ, Van Gelder IC, Henning RH, Tieleman RG, Tuinenburg AE, Wietses M, et al. Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation. Circulation 2001; 103: 684-690.
    • (2001) Circulation , vol.103 , pp. 684-690
    • Brundel, B.J.1    Van Gelder, I.C.2    Henning, R.H.3    Tieleman, R.G.4    Tuinenburg, A.E.5    Wietses, M.6
  • 16
    • 0035923480 scopus 로고    scopus 로고
    • Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: Decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials
    • Dobrev D, Graf E, Wettwer E, Himmel HM, Hala O, Doerfel C, et al. Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials. Circulation 2001; 104: 2551-2557.
    • (2001) Circulation , vol.104 , pp. 2551-2557
    • Dobrev, D.1    Graf, E.2    Wettwer, E.3    Himmel, H.M.4    Hala, O.5    Doerfel, C.6
  • 17
    • 2942645765 scopus 로고    scopus 로고
    • Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium
    • Ehrlich JR, Cha TJ, Zhang L, Chartier D, Villeneuve L, Herbert TE, et al. Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. J Physiol 2004; 557: 583-597.
    • (2004) J Physiol , vol.557 , pp. 583-597
    • Ehrlich, J.R.1    Cha, T.J.2    Zhang, L.3    Chartier, D.4    Villeneuve, L.5    Herbert, T.E.6
  • 18
    • 33644875185 scopus 로고    scopus 로고
    • The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation
    • Dobrev D, Friedrich A, Voigt N, Jost N, Wettwer E, Christ T, et al. The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation. Circulation 2005; 112: 3697-3706.
    • (2005) Circulation , vol.112 , pp. 3697-3706
    • Dobrev, D.1    Friedrich, A.2    Voigt, N.3    Jost, N.4    Wettwer, E.5    Christ, T.6
  • 19
    • 33646694997 scopus 로고    scopus 로고
    • Kir3-based inward rectifier potassium current: Potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias
    • Cha TJ, Ehrlich JR, Chartier D, Qi XY, Xiao L, Nattle S. Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias. Circulation 2006; 113: 1730-1737.
    • (2006) Circulation , vol.113 , pp. 1730-1737
    • Cha, T.J.1    Ehrlich, J.R.2    Chartier, D.3    Qi, X.Y.4    Xiao, L.5    Nattle, S.6
  • 20
    • 0032558390 scopus 로고    scopus 로고
    • + channels
    • + channels. Biochemistry 1998; 37: 13291-13299.
    • (1998) Biochemistry , vol.37 , pp. 13291-13299
    • Jin, W.1    Lu, Z.2
  • 21
    • 0033607190 scopus 로고    scopus 로고
    • + channels
    • + channels. Biochemistry 1999; 38: 14286-14293.
    • (1999) Biochemistry , vol.38 , pp. 14286-14293
    • Jin, W.1    Lu, Z.2
  • 22
    • 33745869067 scopus 로고    scopus 로고
    • Hashimoto N, Yamashita T, Tsuruzoe N. Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation. Pharmacol Res 2006; 54: 136-141.
    • Hashimoto N, Yamashita T, Tsuruzoe N. Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation. Pharmacol Res 2006; 54: 136-141.
  • 26
    • 20444374166 scopus 로고    scopus 로고
    • Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractoty period and action potential duration in guinea pig myocardium
    • Matsuda T, Takeda K, Ito M, Ygmagishi R, Tamura M, Nakamura H, et al. Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractoty period and action potential duration in guinea pig myocardium. J Pharmacol Sci 2005; 98: 33-40.
    • (2005) J Pharmacol Sci , vol.98 , pp. 33-40
    • Matsuda, T.1    Takeda, K.2    Ito, M.3    Ygmagishi, R.4    Tamura, M.5    Nakamura, H.6
  • 27
    • 0036240252 scopus 로고    scopus 로고
    • Effects of a novel class III antiarrhythmic agent, NIP-142, on canine atrial fibrillation and flutter
    • Nagasawa H, Fujiki A, Fujikura N, Matsuda T, Yamashita T, Inoue H. Effects of a novel class III antiarrhythmic agent, NIP-142, on canine atrial fibrillation and flutter. Circ J 2002; 66: 185-191.
    • (2002) Circ J , vol.66 , pp. 185-191
    • Nagasawa, H.1    Fujiki, A.2    Fujikura, N.3    Matsuda, T.4    Yamashita, T.5    Inoue, H.6
  • 28
    • 0036140201 scopus 로고    scopus 로고
    • Effects of NIP-141 on K currents in human atrial myocytes
    • Seki A, Hagiwara N, Kasanuki H. Effects of NIP-141 on K currents in human atrial myocytes. J Cardiovasc Pharmacol 2002; 39: 29-38.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 29-38
    • Seki, A.1    Hagiwara, N.2    Kasanuki, H.3
  • 30
    • 33748945382 scopus 로고    scopus 로고
    • Binding site of a novel Kv1.5 blocker: A "foot in the door" against atrial fibrillation
    • Decher N, Kumar P, Gonzalez T, Pirard B, Sanquinetti MC. Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation. Mol Pharmacol 2006; 70: 1204-1211.
    • (2006) Mol Pharmacol , vol.70 , pp. 1204-1211
    • Decher, N.1    Kumar, P.2    Gonzalez, T.3    Pirard, B.4    Sanquinetti, M.C.5
  • 31
    • 33751262183 scopus 로고    scopus 로고
    • Properties of a Time-dependent Potassium Current in Pig Atrium - Evidence for a Role of Kv1.5 in Repolarization
    • Ehrlich JR, Hoche C, Coutu P, Metz-Weidmann C, Dittrich W, Hohnloser SH, et al. Properties of a Time-dependent Potassium Current in Pig Atrium - Evidence for a Role of Kv1.5 in Repolarization. J Pharmacol Exp Ther 2006; 319: 898-906.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 898-906
    • Ehrlich, J.R.1    Hoche, C.2    Coutu, P.3    Metz-Weidmann, C.4    Dittrich, W.5    Hohnloser, S.H.6
  • 32
    • 5444232406 scopus 로고    scopus 로고
    • Role of IKur in controlling action potential shape and contractility in the human atrium: Influence of chronic atrial fibrillation
    • Wettwer E, Hala O, Christ T, Heubach JF, Doprev D, Knaut M, et al. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation 2004; 110: 2299-2306.
    • (2004) Circulation , vol.110 , pp. 2299-2306
    • Wettwer, E.1    Hala, O.2    Christ, T.3    Heubach, J.F.4    Doprev, D.5    Knaut, M.6
  • 33
    • 33750856807 scopus 로고    scopus 로고
    • Ionic mechanisms underlying human atrial action potential properties: Insights from a mathematical model
    • Courtemanche M, Ramirez RJ, Nattel S. Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 1998; 275: H301-H321.
    • (1998) Am J Physiol , vol.275
    • Courtemanche, M.1    Ramirez, R.J.2    Nattel, S.3
  • 34
    • 33748741192 scopus 로고    scopus 로고
    • AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat
    • de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, et al. AVE0118, Blocker of the Transient Outward Current (Ito) and Ultrarapid Delayed Rectifier Current (IKur), Fully Restores Atrial Contractility After Cardioversion of Atrial Fibrillation in the Goat. Circulation 2006; 114: 1234-1242.
    • (2006) Circulation , vol.114 , pp. 1234-1242
    • de Haan, S.1    Greiser, M.2    Harks, E.3    Blaauw, Y.4    van Hunnik, A.5    Verheule, S.6
  • 36
    • 4644370831 scopus 로고    scopus 로고
    • Early class III drugs for the treatment of atrial fibrillation: Efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat
    • Blaauw Y, Gogelein H, Tieleman RG, van Hunnik A, Schotten U, Allessie MA. "Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat. Circulation 2004; 110: 1717-1724.
    • (2004) Circulation , vol.110 , pp. 1717-1724
    • Blaauw, Y.1    Gogelein, H.2    Tieleman, R.G.3    van Hunnik, A.4    Schotten, U.5    Allessie, M.A.6
  • 37
    • 0033638023 scopus 로고    scopus 로고
    • Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts
    • Nakaya H, Furusawa Y, Ogura T, Tamagawa M, Uemura H. Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts. Br J Pharmacol 2000; 131: 1363-1372.
    • (2000) Br J Pharmacol , vol.131 , pp. 1363-1372
    • Nakaya, H.1    Furusawa, Y.2    Ogura, T.3    Tamagawa, M.4    Uemura, H.5
  • 38
    • 0042237714 scopus 로고    scopus 로고
    • Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model
    • Kumagai K, Nakashima H, Gondo N, Saku K. Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model. J Cardiovasc Electrophysiol 2003; 14: 880-884.
    • (2003) J Cardiovasc Electrophysiol , vol.14 , pp. 880-884
    • Kumagai, K.1    Nakashima, H.2    Gondo, N.3    Saku, K.4
  • 39
    • 0032925839 scopus 로고    scopus 로고
    • Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes
    • Kimura J, Kawahara M, Sakai E, Yatabe J, Nakanishi H. Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. Jpn J Pharmacol 1999; 79: 275-281.
    • (1999) Jpn J Pharmacol , vol.79 , pp. 275-281
    • Kimura, J.1    Kawahara, M.2    Sakai, E.3    Yatabe, J.4    Nakanishi, H.5
  • 41
    • 0027376226 scopus 로고
    • + current similar to Kv1.5 cloned channel currents
    • + current similar to Kv1.5 cloned channel currents. Circ Res 1993; 73: 1061-1076.
    • (1993) Circ Res , vol.73 , pp. 1061-1076
    • Wang, Z.1    Fermini, B.2    Nattel, S.3
  • 43
    • 0033165609 scopus 로고    scopus 로고
    • Cardiac ultrarapid delayed rectifiers: A novel potassium current family o f functional similarity and molecular diversity
    • Nattel S, Yue L, Wang Z. Cardiac ultrarapid delayed rectifiers: a novel potassium current family o f functional similarity and molecular diversity. Cell Physiol Biochem 1999; 9: 217-226.
    • (1999) Cell Physiol Biochem , vol.9 , pp. 217-226
    • Nattel, S.1    Yue, L.2    Wang, Z.3
  • 44
    • 0034666347 scopus 로고    scopus 로고
    • Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium
    • Yue L, Wang Z, Rindt H, Nattel S. Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium. J Physiol 2000; 527 Pt 3: 467-478.
    • (2000) J Physiol , vol.527 , Issue.PART 3 , pp. 467-478
    • Yue, L.1    Wang, Z.2    Rindt, H.3    Nattel, S.4
  • 48
    • 0034782595 scopus 로고    scopus 로고
    • The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation
    • Workman AJ, Kane KA, Rankin AC. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 2001; 52: 226-235.
    • (2001) Cardiovasc Res , vol.52 , pp. 226-235
    • Workman, A.J.1    Kane, K.A.2    Rankin, A.C.3
  • 49
    • 0035154158 scopus 로고    scopus 로고
    • 2+-channel, beta-adrenorecptor, and 5-hydroxytryptamine type 4 receptor mRNAs in human atrial fibrillation
    • 2+-channel, beta-adrenorecptor, and 5-hydroxytryptamine type 4 receptor mRNAs in human atrial fibrillation. Basic Res Cardiol 2001; 96: 82-90.
    • (2001) Basic Res Cardiol , vol.96 , pp. 82-90
    • Grammer, J.B.1    Zeng, X.2    Bosch, R.F.3    Kuhlkamp, V.4
  • 50
    • 10944238690 scopus 로고    scopus 로고
    • Azd7009: A new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis model
    • Goldstein RN, Khrestian C, Carlsson L, Waldo AL. Azd7009: a new antiarrhythmic drug with predominant effects on the atria effectively terminates and prevents reinduction of atrial fibrillation and flutter in the sterile pericarditis model. J Cardiovasc Electrophysiol 2004; 15: 1444-1450.
    • (2004) J Cardiovasc Electrophysiol , vol.15 , pp. 1444-1450
    • Goldstein, R.N.1    Khrestian, C.2    Carlsson, L.3    Waldo, A.L.4
  • 51
    • 21444458758 scopus 로고    scopus 로고
    • Blocking characteristics of hKv1.5 and hKv4.3/hKChIP2.2 after administration of the novel antiarrhythmic compound AZD7009
    • Persson F, Carlsson L, Duker G, Phd IJ. Blocking characteristics of hKv1.5 and hKv4.3/hKChIP2.2 after administration of the novel antiarrhythmic compound AZD7009. J Cardiovasc Pharmacol 2005; 46: 7-17.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 7-17
    • Persson, F.1    Carlsson, L.2    Duker, G.3    Phd, I.J.4
  • 52
    • 15544368375 scopus 로고    scopus 로고
    • Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD70009
    • Persson F, Carlsson L, Duker G, Jacobson I. Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD70009. J Cardiovasc Electrophysiol 2005; 16: 329-341.
    • (2005) J Cardiovasc Electrophysiol , vol.16 , pp. 329-341
    • Persson, F.1    Carlsson, L.2    Duker, G.3    Jacobson, I.4
  • 53
    • 33646684512 scopus 로고    scopus 로고
    • Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog
    • Carlsson L, Chartier D, Nattel S. Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog. J Cardiovasc Pharmacol 2006; 47: 123-132.
    • (2006) J Cardiovasc Pharmacol , vol.47 , pp. 123-132
    • Carlsson, L.1    Chartier, D.2    Nattel, S.3
  • 54
    • 33745584362 scopus 로고    scopus 로고
    • Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: A comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro
    • Lofberg L, Jacobson I, Carlsson L. Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: a comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro. Europace 2006; 8: 549-557.
    • (2006) Europace , vol.8 , pp. 549-557
    • Lofberg, L.1    Jacobson, I.2    Carlsson, L.3
  • 57
    • 27744502501 scopus 로고    scopus 로고
    • In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide
    • Stump GL, Wallace AA, Regan CP, Lynch JJ Jr. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther 2005; 315: 1362-1367.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1362-1367
    • Stump, G.L.1    Wallace, A.A.2    Regan, C.P.3    Lynch Jr., J.J.4
  • 58
    • 31144478800 scopus 로고    scopus 로고
    • In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate
    • Regan CP, Wallace AA, Cresswell HK, Lynch JJ Jr. In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J Pharmacol Exp Ther 2006; 316: 727-732.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 727-732
    • Regan, C.P.1    Wallace, A.A.2    Cresswell, H.K.3    Lynch Jr., J.J.4
  • 59
  • 60
    • 0036033595 scopus 로고    scopus 로고
    • Knobloch K, Brendel J, Peukert S, Rosenstein B, Busch AE, Wirth KJ. Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol 2002; 366: 482-487.
    • Knobloch K, Brendel J, Peukert S, Rosenstein B, Busch AE, Wirth KJ. Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol 2002; 366: 482-487.
  • 62
    • 33646003589 scopus 로고    scopus 로고
    • The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers
    • Fedida D, Orth PM, Hesketh JC, Ezrin AM. The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol 2006; 17 Suppl 1: S71-S78.
    • (2006) J Cardiovasc Electrophysiol , vol.17 , Issue.SUPPL. 1
    • Fedida, D.1    Orth, P.M.2    Hesketh, J.C.3    Ezrin, A.M.4
  • 63
    • 33646535323 scopus 로고    scopus 로고
    • RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents
    • Orth PM, Hesketh JC, Mak CK, Yang Y, Lin S, Beatch GN, et al. RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents. Cardiovasc Res 2006; 70: 486-496.
    • (2006) Cardiovasc Res , vol.70 , pp. 486-496
    • Orth, P.M.1    Hesketh, J.C.2    Mak, C.K.3    Yang, Y.4    Lin, S.5    Beatch, G.N.6
  • 64
    • 10644250949 scopus 로고    scopus 로고
    • A randomized, controlled trial of RSD1235, a novel anti-arrhythmic agent, in the treatment of recent onset atrial fibrillation
    • Roy D, Rowe BH, Stiell IG, Coutu B, Ip JH, Phaneuf D, et al. A randomized, controlled trial of RSD1235, a novel anti-arrhythmic agent, in the treatment of recent onset atrial fibrillation. J Am Coll Cardiol 2004; 44: 2355-2361.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2355-2361
    • Roy, D.1    Rowe, B.H.2    Stiell, I.G.3    Coutu, B.4    Ip, J.H.5    Phaneuf, D.6
  • 66
    • 0033586731 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3
    • Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, et al. Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry 1999; 38: 4922-4930.
    • (1999) Biochemistry , vol.38 , pp. 4922-4930
    • Felix, J.P.1    Bugianesi, R.M.2    Schmalhofer, W.A.3    Borris, R.4    Goetz, M.A.5    Hensens, O.D.6
  • 67
    • 4043123181 scopus 로고    scopus 로고
    • + channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: Ionic diversity in smooth muscle cells
    • + channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res 2004; 95: 308-318.
    • (2004) Circ Res , vol.95 , pp. 308-318
    • Archer, S.L.1    Wu, X.C.2    Thebaud, B.3    Nsair, A.4    Bonnet, S.5    Tyrrell, B.6
  • 68
    • 0029790924 scopus 로고    scopus 로고
    • Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels
    • Valenzuela C, Delpon E, Franqueza L, Gay P, Perez O, Tamargo J, et al. Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels. Circulation 1996; 94: 562-570.
    • (1996) Circulation , vol.94 , pp. 562-570
    • Valenzuela, C.1    Delpon, E.2    Franqueza, L.3    Gay, P.4    Perez, O.5    Tamargo, J.6
  • 69
    • 0030768949 scopus 로고    scopus 로고
    • Block of human cardiac Kv1.5 channels by loratadine: Voltage-, time- and use-dependent block at concentrations above therapeutic levels
    • Delpon E, Valenzuela C, Gay P, Franqueza L, Synders DJ, Tamargo J. Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels. Cardiovasc Res 1997; 35: 341-350.
    • (1997) Cardiovasc Res , vol.35 , pp. 341-350
    • Delpon, E.1    Valenzuela, C.2    Gay, P.3    Franqueza, L.4    Synders, D.J.5    Tamargo, J.6
  • 72
    • 0035065220 scopus 로고    scopus 로고
    • Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization
    • Caballero R, Delpon E, Valenzuela C, Longobardo M, Gonzalez T, Tamargo J. Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization. Mol Pharmacol 2001; 59: 825-836.
    • (2001) Mol Pharmacol , vol.59 , pp. 825-836
    • Caballero, R.1    Delpon, E.2    Valenzuela, C.3    Longobardo, M.4    Gonzalez, T.5    Tamargo, J.6
  • 73
    • 33645236163 scopus 로고    scopus 로고
    • Role of angiotensin system and effects of its inhibition in atrial fibrillation: Clinical and experimental evidence
    • Ehrlich JR, Hohnloser SH, Nattel S. Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence. Eur Heart J 2006; 27: 512-518.
    • (2006) Eur Heart J , vol.27 , pp. 512-518
    • Ehrlich, J.R.1    Hohnloser, S.H.2    Nattel, S.3
  • 74
    • 0034612362 scopus 로고    scopus 로고
    • Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation
    • Nakashima H, Kumagai K, Urata H, Gondo N, Ideishi M, Arakawa K. Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation. Circulation 2000; 101: 2612-2617.
    • (2000) Circulation , vol.101 , pp. 2612-2617
    • Nakashima, H.1    Kumagai, K.2    Urata, H.3    Gondo, N.4    Ideishi, M.5    Arakawa, K.6
  • 75
    • 0037118662 scopus 로고    scopus 로고
    • Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: A prospective and randomized study
    • Madrid AH, Bueno MG, Rebollo JM, Marin I, Pena G, Bernal E, et al. Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study. Circulation 2002; 106: 331-336.
    • (2002) Circulation , vol.106 , pp. 331-336
    • Madrid, A.H.1    Bueno, M.G.2    Rebollo, J.M.3    Marin, I.4    Pena, G.5    Bernal, E.6
  • 76
    • 0032979852 scopus 로고    scopus 로고
    • Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias
    • Saffitz JE, Schuessler RB, Yamada KA. Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias. Cardiovasc Res 1999; 42: 309-317.
    • (1999) Cardiovasc Res , vol.42 , pp. 309-317
    • Saffitz, J.E.1    Schuessler, R.B.2    Yamada, K.A.3
  • 77
    • 0033596919 scopus 로고    scopus 로고
    • Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation
    • Hagendorff A, Schumacher B, Kirchhoff S, Luderitz B, Willecke K. Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation. Circulation 1999; 99: 1508-1515.
    • (1999) Circulation , vol.99 , pp. 1508-1515
    • Hagendorff, A.1    Schumacher, B.2    Kirchhoff, S.3    Luderitz, B.4    Willecke, K.5
  • 79
    • 33644821264 scopus 로고    scopus 로고
    • Atrial distribution of connexin 40 and 43 in patients with intermittent, persistent, and postoperative atrial fibrillation
    • Wilhelm M, Kirste W, Kuly S, Amann K, Neuhuber W, Weyand M, et al. Atrial distribution of connexin 40 and 43 in patients with intermittent, persistent, and postoperative atrial fibrillation. Heart Lung Circ 2006; 15: 30-37.
    • (2006) Heart Lung Circ , vol.15 , pp. 30-37
    • Wilhelm, M.1    Kirste, W.2    Kuly, S.3    Amann, K.4    Neuhuber, W.5    Weyand, M.6
  • 81
    • 33745246602 scopus 로고    scopus 로고
    • Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation
    • Gollob MH, Jones DL, Krahn AD, Danis L, Gong XQ, Shao Q, et al. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med 2006; 354: 2677-2688.
    • (2006) N Engl J Med , vol.354 , pp. 2677-2688
    • Gollob, M.H.1    Jones, D.L.2    Krahn, A.D.3    Danis, L.4    Gong, X.Q.5    Shao, Q.6
  • 82
    • 0347418930 scopus 로고    scopus 로고
    • Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: Evidence supporting a novel target for antiarrhythmic therapy
    • Eloff BC, Gilat E, Wan X, Rosenbaum DS. Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: evidence supporting a novel target for antiarrhythmic therapy. Circulation 2003; 108: 3157-3163.
    • (2003) Circulation , vol.108 , pp. 3157-3163
    • Eloff, B.C.1    Gilat, E.2    Wan, X.3    Rosenbaum, D.S.4
  • 83
    • 0020058977 scopus 로고
    • Studies of heart. XXI. Amino acid sequence of antiarrhythmic peptide (AAP) isolated from atria
    • Aonuma S, Kohama Y, Makino T, Fujisawa Y. Studies of heart. XXI. Amino acid sequence of antiarrhythmic peptide (AAP) isolated from atria. J Pharmacobiodyn 1982; 5: 40-48.
    • (1982) J Pharmacobiodyn , vol.5 , pp. 40-48
    • Aonuma, S.1    Kohama, Y.2    Makino, T.3    Fujisawa, Y.4
  • 84
    • 0038662776 scopus 로고    scopus 로고
    • ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs
    • Xing D, Kjolbye AL, Nielsen MS, Petersen JS, Harlow KW, Holstein-Rathlou NH, et al. ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs. J Cardiovasc Electrophysiol 2003; 14: 510-520.
    • (2003) J Cardiovasc Electrophysiol , vol.14 , pp. 510-520
    • Xing, D.1    Kjolbye, A.L.2    Nielsen, M.S.3    Petersen, J.S.4    Harlow, K.W.5    Holstein-Rathlou, N.H.6
  • 86
    • 33747031207 scopus 로고    scopus 로고
    • Effects of the Gap Junction Modifier Rotigaptide (ZP123) on Atrial Conduction and Vulnerability to Atrial Fibrillation
    • Guerra JM, Everett TH, Lee KW, Wilson E, Olgin JE. Effects of the Gap Junction Modifier Rotigaptide (ZP123) on Atrial Conduction and Vulnerability to Atrial Fibrillation. Circulation 2006; 114: 110-118.
    • (2006) Circulation , vol.114 , pp. 110-118
    • Guerra, J.M.1    Everett, T.H.2    Lee, K.W.3    Wilson, E.4    Olgin, J.E.5
  • 88
    • 54949142814 scopus 로고    scopus 로고
    • Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. Circulation 2006; in revision:
    • Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. Circulation 2006; in revision:
  • 89
    • 33747814786 scopus 로고    scopus 로고
    • Blockade by NIP-142, an Antiarrhythmic Agent, of Carbachol-Induced Atrial Action Potential Shortening and GIRK1/4 Channel
    • Matsuda T, Ito M, Ishimaru S, Tsuruoka N, Saito T, Iida-Tanaka N, et al. Blockade by NIP-142, an Antiarrhythmic Agent, of Carbachol-Induced Atrial Action Potential Shortening and GIRK1/4 Channel. J Pharmacol Sci 2006; 101: 303-310.
    • (2006) J Pharmacol Sci , vol.101 , pp. 303-310
    • Matsuda, T.1    Ito, M.2    Ishimaru, S.3    Tsuruoka, N.4    Saito, T.5    Iida-Tanaka, N.6
  • 90
    • 0033780037 scopus 로고    scopus 로고
    • The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks
    • Drici MD, Diochot S, Terrenoire C, Romey G, Lazdunski M. The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks. Br J Pharmacol 2000; 131: 569-577.
    • (2000) Br J Pharmacol , vol.131 , pp. 569-577
    • Drici, M.D.1    Diochot, S.2    Terrenoire, C.3    Romey, G.4    Lazdunski, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.