Molecular basis of downregulation of G-protein -coupled inward rectifying k+ current (ik,ach) in chronic human atrial fibrillation decrease in GIRK4 mrna correlates with reduced IK,ACh and muscarinic receptor-mediated shortening of action potentials

Circulation

Volumn 104, Issue 21, 2001, Pages 2551-2557

  Dobrev, Dobromir ^a,b   Graf, E ^a   Wettwer, E ^a   Himmel, H M ^a   Hala O ^a   Doerfel, C ^a   Christ, T ^a   Schuler S ^a   Ravens, U ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Action potentials; Fibrillation; Ion channels; Remodeling

Indexed keywords

G PROTEIN COUPLED RECEPTOR; ION CHANNEL; MUSCARINIC RECEPTOR;

ACTION POTENTIAL; ADULT; AGED; ARTICLE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; HUMAN; MALE; MEMBRANE POTENTIAL; PATHOGENESIS; POTASSIUM CURRENT; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS RHYTHM; TRANSCRIPTION REGULATION;

EID: 0035923480     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4601.099466     Document Type: Article

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