Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes

Japanese Journal of Pharmacology

Volumn 79, Issue 3, 1999, Pages 275-281

  Kimura, Junko ^a   Kawahara, Masanori ^a   Sakai, Eiichi ^a   Yatabe, Junichi ^a   Nakanishi, Hironori ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Antiarrhythmic drug; Cardiac myocyte; JTV 519; Na+ channel; Na+ channel inhibitor

Indexed keywords

4 [3 (4 BENZYLPIPERIDIN 1 YL)PROPIONYL] 7 METHOXY 2,3,4,5 TETRAHYDRO 1,4 BENZOTHIAZEPINE MONOHYDROCHLORIDE; 4 [3 [1 (4 BENZYL)PIPERIDINYL]PROPIONYL] 7 METHOXY 2,3,4,5 TETRAHYDRO 1,4 BENZOTHIAZEPINE; ANTIARRHYTHMIC AGENT; LIDOCAINE; QUINIDINE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CELL; HEART PROTECTION; MALE; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; SODIUM CURRENT;

EID: 0032925839     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.275     Document Type: Article

References (29)

1. Kaneko N: New 1,4-benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action. Drug Dev Res 33, 429-438 (1994)
2. Kaneko N: Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. J Mol Biol 274, 16-20 (1997)
3. 2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazpine derivative. Biochim Biophys Acta 1330, 1-7 (1997)
4. Miyai H, Suzuki Y, Kanada A, Iwata K, Kaneko N and Aisaka K: Effect of JTV-519, a new organ-protective drug, on cardiovascular system. Jpn J Phamacol 76, Suppl I, 280P (1998)
5. 2+ overload. J Mol Cell Cardiol 30, A323 (1998)
6. Miyai H, Suzuki Y, Okaya Y, Iwata K, Kaneko N and Aisaka K: Anti-ischaemic effect of JTV-519, a new cardioprotective drug, in dogs. J Mol Cell Cardiol 30, A323 (1998)
7. Ito K, Sato T, Abe T, Li Y and Arita M: Anti-stunning effects of JTV-519 in coronary perfused guinea pig ventricular muscles. J Mol Cell Cardiol 30, A324 (1998)
8. Woosley RL: Antiarrhythmic drugs. Annu Rev Pharmacol Toxicol 31, 427-455 (1991)
9. Grant AO, Whalley DW and Wendt DJ: Pharmacology of the cardiac sodium channel. In Cardiac Electrophysiology - From Cell to Bedside, 2nd ed, Edted by Zipes DP and Jalife J, pp 247-259, WB Saunders Company, Philadelphia (1995)
10. Hille B: Local anesthetics: hydrophilic and hydrophobic pathway for the drug-receptor reaction. J Gen Physiol 69, 497-515 (1977)
11. Hondeghem LM and Katzung BG: Time-and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochem Biophys Acta 472, 373-398 (1977)
12. Hondeghem LM and Katzung BG: Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs. Annu Rev Pharmacol 24, 387-423 (1984)
13. + channels by local anesthetics. Science 265, 1724-1728 (1994)
14. Roden DM and George AL Jr: Structure and function of cardiac sodium and potassium channels. Am J Physiol 273, H511-H525 (1997)
15. Catterall WA: Molecular analysis of voltage gated sodium channels in the heart and other tissues. In Cardiac Electrophysiology - From Cell to Bedside, 2nd ed, Edted by Zipes DP and Jalife J, pp 1-10, WB Saunders Company, Philadelphia (1995)
16. Yazawa K, Kaibara M, Ohara M and Kameyama M: An improved method for isolating cardiac myocytes useful for patchclamp studies. Jpn J Physiol 40, 157-163 (1990)
17. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ: Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflugers Arch 391, 85-100 (1981)
18. + channels by antiarrhythmic drugs, neurotransmitters and hormones. Trends Pharmacol Sci 13, 352-358 (1992)
19. Bean BP, Cohen CJ and Tsien RW: Lidocaine block of cardiac sodium channels. J Gen Physiol 81, 613-642 (1983)
20. Courtney KR: Why do some drugs preferentially block open sodium channels? J Mol Cell Cardiol 20, 461-464 (1988)
21. max) of action potential in guinea-pig cardiac muscles. J Mol Cell Cardiol 19, 367-377 (1987)
22. + current in rat ventricle. Br J Pharmacol 115, 335-343 (1995)
23. + current of guinea-pig ventricular myocytes. J Physiol (Lond) 435, 65-81 (1991)
24. Kiyosue T and Arita M: Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circ Res 64, 389-397 (1989)
25. Kunze DL, Lacerda AE, Wilson DL and Brown AM: Cardiac Na currents and the inactivating, reopening and waiting properties of single cardiac Na channels. J Gen Physiol 86, 691-719 (1985)
26. Saint DA, Ju YK and Gage PW: Persistent sodium current in rat ventricular myocytes. J Physiol (Lond) 453, 219-231 (1992)
27. Kaneko N, Shimamoto K, Chiwaki F, Toda M and Matsuda T: Cardioprotective effect of JTV519 (K201) in eschemia-reperfusion heart and its mechanism. Jpn Circ J 62, Suppl I, 333 (1998) (in Japanese)
28. Inagaki H, Kihara Y, Hayashida H and Sasayama S: A new cardioprotective drug, JTV-519, shows an anti-ischemic effect via activation of protein kinase C. Jpn Circ J 62, Suppl I, 149 (1998) (in Japanese)
29. Ito K, Sato T, Abe T, Li G and Arita M: Inhibitory effect of JTV-519 on ischemic stunning in the extracted right ventricle of guinea pig. Jpn Circ J 62, Suppl I, 150 (1998) (in Japanese)