Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias

Cardiovascular Research

Volumn 42, Issue 2, 1999, Pages 309-317

  Saffitz, Jeffrey E ^a   Schuessler, Richard B ^a   Yamada, Kathryn A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN;

ARRHYTHMOGENESIS; CELL COMMUNICATION; CELLULAR DISTRIBUTION; CYTOARCHITECTURE; CYTOLYSIS; GAP JUNCTION; HEART ARRHYTHMIA; HEART HYPERTROPHY; HEART INJURY; HEART MUSCLE CELL; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW;

ANIMALS; ARRHYTHMIA; CARDIOMEGALY; CHRONIC DISEASE; CONNEXIN 43; GAP JUNCTIONS; GENE EXPRESSION REGULATION; GUINEA PIGS; HEART VENTRICLES; HUMANS; ION CHANNELS; ION TRANSPORT; MYOCARDIUM; RATS; VENTRICULAR REMODELING;

EID: 0032979852     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00023-1     Document Type: Review

References (49)

1. Janse M.J., Wit A.L. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev. 69:1989;1049-1169.
2. Hurwitz J.L., Josephson M.E. Sudden cardiac death in patients with chronic coronary heart disease. Circulation. 85:(Suppl I):1992;I-43-I-49.
3. Gardner P.I., Ursell P.C., Fenoglio J.J. Jr., Wit A.L. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation. 72:1985;596-611.
4. Ursell P.C., Gardner P.I., Albala A., Fenoglio J.J., Wit A.L. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 56:1985;436-451.
5. Dillon S.M., Allessie M.A., Ursell P.C., Wit A.L. Influences of anisotropic tissue structure and reentrant circuits in the epicardial border zone of subacute canine infarcts. Circ Res. 63:1988;182-206.
6. DeBakker M.J.T., van Capelle F.J.L., Janse M.J., et al. Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation. 88:1993;915-926.
7. Peters N.S., Coromilas J., Severs N.J., Wit A.L. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation. 95:1997;988-996.
8. Boyden P.A., Gardner P.I., Wit A.L. Action potentials of cardiac muscle in healing infarcts: response to norepinephrine and caffeine. J Mol Cell Cardiol. 20:1988;525-537.
9. Guerrero P.A., Schuessler R.B., Davis L.M., et al. Slow ventricular conduction in mice heterozygous for a Cx43 null mutation. J Clin Invest. 99:1997;1991-1998.
10. Thomas S.A., Schuessler R.B., Berul C.I., et al. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: Evidence for chamber-specific molecular determinants of conduction. Circulation. 97:1998;686-691.
11. Coppen S.R., Dupont E., Rothery S., Severs N.J. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res. 82:1998;232-243.
12. Page E. Cardiac gap junctions. Fozzard H.A., Haber E., Jennings R.B., Katz A.M., Morgan H.E. The heart and cardiovascular system. 1992;1003-1047 Raven Press, New York, NY.
13. Davis L.M., Kanter H.L., Beyer E.C., Saffitz J.E. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol. 24:1994;1124-1132.
14. Saffitz J.E., Kanter H.L., Green K.G., Tolley T.K., Beyer E.C. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 74:1994;1065-1070.
15. Pressler ML, Münster PN, Huang X. Gap junction distribution in the heart: functional relevance, in Cardiac Electrophysiology From Cell to Bedside, 2nd Ed, Zipes DP and Jalife J, eds, Philadelphia, WB Saunders, 1995, pp. 144-151.
16. Spach M.S., Miller W.T. III, Dolber P.C., et al. The functional role of structural complexities in the propagation of depolarization in the atrium of the dog: cardiac conduction disturbances due to discontinuities of effective axial resistivity. Circ Res. 50:1982;175-191.
17. Luke R.A., Saffitz J.E. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest. 87:1991;1594-1602.
18. Smith J.H., Green C.R., Peters N.S., Rothery S., Severs N.J. Altered patterns of gap junction distribution in ischemic heart disease: an immunohistochemical study of human myocardium using laser scanning confocal microscopy. Am J Pathol. 139:1991;801-821.
19. Peters N.S., Green C.R., Poole-Wilson P.A., Severs N.J. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation. 88:1993;864-875.
20. Kaprielian R.R., Gunning M., Dupont E., et al. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation. 97:1998;651-660.
21. Darrow B.J., Fast V.G., Kléber A.G., Beyer E.C., Saffitz J.E. Functional and structural assessment of intercellular communication: increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 79:1996;174-183.
22. Dodge S.M., Beardslee M.A., Darrow B.J., et al. Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol. 32:1998;800-807.
23. Peters N.S., del Monte F., MacLeod K.T., et al. Increased cardiac myocyte gap-junctional membrane early in renovascular hypertension. J Am Coll Cardiol. 21:1993;59A. abstract.
24. Bastide B., Neyses L., Ganten D., et al. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions. Circ Res. 73:1993;1138-1149.
25. Toyoshima H., Park Y.-D., Ishikawa Y., et al. Effect of ventricular hypertrophy on conduction velocity of activation front in the ventricular myocardium. Am J Cardiol. 49:1982;1938-1945.
26. Winterton S.J., Turner M.A., O'Gorman D.J., Flores N.A., Sheridan D.J. Hypertrophy causes delayed conduction in human and guinea pig myocardium: accentuation during ischaemic perfusion. Cardiovasc Res. 23:1994;47-54.
27. Cooklin M., Wallis W.R.J., Sheridan D.J., Fry C.H. Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy. Circ Res. 80:1997;765-771.
28. McIntyre H., Fry C.H. Abnormal action potential conduction in isolated human hypertrophied left ventricular myocardium. J Cardiovasc Electrophysiol. 8:1997;887-894.
29. Peters N.S. New insights into myocardial arrhythmogenesis: distribution of gap junctional coupling in normal, ischaemic and hypertrophied human hearts. Clin Sci. 90:1996;447-452.
30. Spach M.S., Dolber P.C. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Circ Res. 58:1986;356-371.
31. Dolber P.C., Spach M.S. Structure of canine Bachmann's bundle related to propagation of excitation. Am J Physiol. 257:(Heart Circ Physiol):1989;H1446-H1457.
32. van der Velden H.M., van Kempen M.J., Wijffels M.C., et al. Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat. J Cardiovasc Electrophysiol. 9:1998;596-607.
33. Maes A., Flameng W., Nuyts J., et al. Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings. Circulation. 90:1994;735-745.
34. Ausma J., Schaart G., Thoné F., et al. Chronic ischemic viable myocardium in man: Aspects of dedifferentiation. Cardiovasc Pathol. 4:1995;29-37.
35. Borgers M., Thone F., Wouters L., et al. Structural correlates of regional myocardial dysfunction in patients with critical coronary artery stenosis: chronic hibernation? Cardiovasc Pathol. 2:1993;237-245.
36. Schaper J., Froede R., Hein S., et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation. 83:1991;504-514.
37. Sharp W.W., Terracio L., Borg T.K., Samarel A.M. Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circ Res. 73:1993;172-183.
38. Ausma J., Wijffels M., van Eys G., et al. Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation. Am J Pathol. 151:1997;985-997.
39. Sack M.N., Rader T.A., Park S., et al. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation. 94:1996;2837-2842.
40. Peters N.S., Severs N.J., Rothery S., et al. Spatiotemporal relations between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium. Circulation. 90:1994;713-725.
41. Van Eyk J.E., Powers F., Law W., et al. Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: Identification of degradation products and effects on the pCa-force relation. Circ Res. 82:1998;261-271.
42. Ciechanover A.J., Schwartz A.L. Modern Cell Biol. Cellular proteolytic systems. 15:1994;Wiley-Liss, New York.
43. Ciechanover A.J. The ubiquitin-proteasome proteolytic pathway. Cell. 79:1994;13-21.
44. Laird D.W., Puranam K.L., Revel J.P. Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. Biochem J. 273:1991;67-72.
45. Darrow B.J., Laing J.G., Lampe P.D., Saffitz J.E., Beyer E.C. Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 76:1995;381-387.
46. Laing J.G., Tadros P.N., Green K., Saffitz J.E., Beyer E.C. Proteolysis of connexin43 containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc Res. 38:1998;711-718.
47. Beardslee M.A., Laing J.G., Beyer E.C., Saffitz J.E. Rapid turnover of connexin43 in the adult rat heart. Circ Res. 83:1998;629-635.
48. Makowski L., Caspar D.L.D., Phillips W.C., Goodenough D.A. Gap junction structures. II. Analysis of the x-ray diffraction data. J Cell Biol. 74:1977;629-745.
49. Saffitz J.E., Corr P.B., Sobel B.E. Arrhythmogenesis and ventricular dysfunction after myocardial infarction: Is anomalous cellular coupling the elusive link? Circulation. 87:1993;1742-1745.